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Scientific opinion on the maximum levels of cross\u2010contamination for 24 antimicrobial active substances in non\u2010target feed. Part 13: Diaminopyrimidines: trimethoprim. EFSA Journal 2021;19(10):6865, 19 pp. https:\/\/doi.org\/10.2903\/j.efsa.2021.6865","DOI":"10.2903\/j.efsa.2021.6865"},{"key":"10.2903\/j.efsa.2021.6862_ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0044-8486(94)90096-5","article-title":"Multiple\u2010dose pharmacokinetic study of flumequine in Atlantic salmon (Salmo salar L.)","volume":"128","author":"Elema","year":"1994","journal-title":"Aquaculture"},{"key":"10.2903\/j.efsa.2021.6862_ref30","unstructured":"EMEA\/CVMP (European Agency for the Evaluation of Medicinal Products \u2010 Committee for Veterinary Medicinal Products), 1999. Flumequine. Summary Report (2). EMEA\/MRL\/624\/99-FINAL July 1999. 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