{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:41:35Z","timestamp":1776354095417,"version":"3.51.2"},"reference-count":24,"publisher":"Wiley","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.2903\/j.efsa.2023.7911","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T09:12:39Z","timestamp":1680167559000},"source":"Crossref","is-referenced-by-count":1,"title":["Safety evaluation of the food enzyme glucan 1,4\u2010\u03b1\u2010glucosidase from the non\u2010genetically modified Aspergillus niger strain NZYM\u2010BO"],"prefix":"10.2903","volume":"21","author":[{"name":"EFSA Panel on Food Contact Materials; Enzymes and Processing Aids (CEP)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Lambr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Barat Baviera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Sandro","family":"Cocconcelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Crebelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Michael","family":"Gott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konrad","family":"Grob","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Lampi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Mengelers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Rivi\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger\u2010Lise","family":"Steffensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Tlustos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"Van Loveren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Vernis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lieve","family":"Herman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yrj\u00f6","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Aguilera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Andryszkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Cavanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Criado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"N\u00f8rby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulio","family":"di Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Peluso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Chesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2023.7911_ref1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.aller.2009.05.001","article-title":"Why can patients with baker's asthma tolerate wheat flour ingestion? Is wheat pollen allergy relevant?","volume":"37","author":"Armentia","year":"2009","journal-title":"Allergologia et Immunopathologia"},{"key":"10.2903\/j.efsa.2023.7911_ref2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1398-9995.1995.tb02487.x","article-title":"Allergic reaction after eating \u03b1\u2010amylase (Asp o 2)\u2010containing bred. A case report","volume":"50","author":"Baur","year":"1995","journal-title":"Allergy"},{"key":"10.2903\/j.efsa.2023.7911_ref3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1398-9995.1997.tb01003.x","article-title":"Clinical responses to ingested fungal \u03b1\u2010amylase and hemicellulase in persons sensitized to Aspergillus fumigatus?","volume":"52","author":"Cullinan","year":"1997","journal-title":"Allergy"},{"key":"10.2903\/j.efsa.2023.7911_ref4","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) , 2006. Opinion of the Scientific Committee related to uncertainties in dietary exposure assessment. EFSA Journal 2006;5(1):438, 54 pp. https:\/\/doi.org\/10.2903\/j.efsa.2007.438","DOI":"10.2903\/j.efsa.2007.438"},{"key":"10.2903\/j.efsa.2023.7911_ref5","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) , 2009a. Guidance of EFSA prepared by the Scientific Panel of Food Contact Material, Enzymes, Flavourings and Processing Aids on the Submission of a Dossier on Food Enzymes. EFSA Journal 2009;7(8):1305, 26 pp. https:\/\/doi.org\/10.2903\/j.efsa.2009.1305","DOI":"10.2903\/j.efsa.2009.1305"},{"key":"10.2903\/j.efsa.2023.7911_ref6","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) , 2009b. Guidance of the Scientific Committee on transparency in the scientific aspects of risk assessments carried out by EFSA. Part 2: general principles. EFSA Journal 2009;7(5):1051, 22 pp. https:\/\/doi.org\/10.2903\/j.efsa.2009.1051","DOI":"10.2903\/j.efsa.2009.1051"},{"key":"10.2903\/j.efsa.2023.7911_ref7","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) , 2011. Use of the EFSA Comprehensive European Food Consumption Database in Exposure Assessment. EFSA Journal 2011;9(3):2097, 34 pp. https:\/\/doi.org\/10.2903\/j.efsa.2011.2097","DOI":"10.2903\/j.efsa.2011.2097"},{"key":"10.2903\/j.efsa.2023.7911_ref8","doi-asserted-by":"crossref","unstructured":"EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes and Processing Aids) , 2019. Statement on the characterisation of microorganisms used for the production of food enzymes. EFSA Journal 2019;17(6):5741, 13 pp. https:\/\/doi.org\/10.2903\/j.efsa.2019.5741","DOI":"10.2903\/j.efsa.2019.5741"},{"key":"10.2903\/j.efsa.2023.7911_ref9","doi-asserted-by":"crossref","unstructured":"EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes and Processing Aids) , Lambr\u00e9 C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Rivi\u00e8re G, Steffensen I\u2010L, Tlustos C, Van Loveren H, Vernis L, Zorn H, Glandorf B, Herman L, Aguilera J, Andryszkiewicz M, Gomes A, Kovalkovicova N, Liu Y, Rainieri S and Chesson A, 2021a. Scientific Guidance for the submission of dossiers on Food Enzymes. EFSA Journal 2021;19(10):6851, 37 pp. https:\/\/doi.org\/10.2903\/j.efsa.2021.6851","DOI":"10.2903\/j.efsa.2021.6851"},{"key":"10.2903\/j.efsa.2023.7911_ref10","doi-asserted-by":"crossref","unstructured":"EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes and Processing Aids) , Lambr\u00e9 C, Barat Baviera JM, Bolognesi C, Cocconcelli PS, Crebelli R, Gott DM, Grob K, Lampi E, Mengelers M, Mortensen A, Rivi\u00e8re G, Steffensen I\u2010L, Tlustos C, van Loveren H, Vernis L, Zorn H, Liu Y and Chesson A, 2021b. Statement on the process\u2010specific technical data used in exposure assessment of food enzymes. EFSA Journal 2021;19(12):7010, 38 pp. https:\/\/doi.org\/10.2903\/j.efsa.2021.7010","DOI":"10.2903\/j.efsa.2021.7010"},{"key":"10.2903\/j.efsa.2023.7911_ref11","doi-asserted-by":"crossref","unstructured":"EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms) , 2010. Scientific Opinion on the assessment of allergenicity of GM plants and microorganisms and derived food and feed. EFSA Journal 2010;8(7):1700, 168 pp. https:\/\/doi.org\/10.2903\/j.efsa.2010.1700","DOI":"10.2903\/j.efsa.2010.1700"},{"key":"10.2903\/j.efsa.2023.7911_ref12","first-page":"63","article-title":"General specifications and considerations for enzyme preparations used in food processing in Compendium of food additive specifications. 67th meeting","volume":"3","author":"FAO\/WHO (Food and Agriculture Organization of the United Nations\/World Health Organization)","year":"2006","journal-title":"FAO JECFA Monographs"},{"key":"10.2903\/j.efsa.2023.7911_ref13","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1177\/0192623312438736","article-title":"Proliferative and nonproliferative lesions of the rat and mouse urinary system","volume":"40","author":"Frazier","year":"2012","journal-title":"Toxicologic Pathology"},{"key":"10.2903\/j.efsa.2023.7911_ref14","doi-asserted-by":"crossref","first-page":"9481","DOI":"10.1007\/s00253-018-9354-1","article-title":"Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus Niger, Aspergillus oryzae, and Trichoderma reesei","volume":"102","author":"Frisvad","year":"2018","journal-title":"Applied Microbiology and Biotechnology"},{"key":"10.2903\/j.efsa.2023.7911_ref15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0091-6749(95)70161-3","article-title":"\u0391\u2010amylase contained in bread can induce food allergy","volume":"95","author":"Kanny","year":"1995","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.2903\/j.efsa.2023.7911_ref16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0091-6749(05)80048-X","article-title":"Occupational asthma caused by \u03b1\u2010amylase inhalation: clinical and immunologic findings and bronchial response patterns","volume":"89","author":"Losada","year":"1992","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.2903\/j.efsa.2023.7911_ref17","first-page":"346","article-title":"Bread eating induced oral angioedema due to \u03b1\u2010amylase allergy","volume":"14","author":"Moreno\u2010Ancillo","year":"2004","journal-title":"Journal of Investigative Allergology and Clinical Immunology"},{"key":"10.2903\/j.efsa.2023.7911_ref18","volume-title":"OECD Guideline for the testing of chemicals, Section 4 Health effects, Test No. 408: Repeated dose 90\u2010day oral toxicity study in rodents","author":"OECD (Organisation for Economic Co\u2010Operation and Development)","year":"1981"},{"key":"10.2903\/j.efsa.2023.7911_ref19","volume-title":"In vitro mammalian cell micronucleus test","author":"OECD (Organisation for Economic Co\u2010Operation and Development)","year":"2016"},{"key":"10.2903\/j.efsa.2023.7911_ref20","unstructured":"OECD (Organisation for Economic Co\u2010Operation and Development) , 2020. OECD Guideline for the testing of chemicals, Section 4 Health effects, Test No. 471: Bacterial reverse mutation test. 29 June 2020. 11 pp. Available online: https:\/\/www.oecd\u2010ilibrary.org\/docserver\/9789264071247\u2010en.pdf?expires=1660741244&id=id&accname=guest&checksum=913CB0A044880B3F24CBF2A547CF413C"},{"key":"10.2903\/j.efsa.2023.7911_ref21","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/mnfr.200400029","article-title":"Allergy assessment of foods or ingredients derived from biotechnology, gene\u2010modified organisms, or novel food","volume":"48","author":"Poulsen","year":"2004","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.2903\/j.efsa.2023.7911_ref22","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/0091-6749(92)90470-M","article-title":"Respiratory allergy to Aspergillus\u2010derived enzymes in bakers' asthma","volume":"90","author":"Quirce","year":"1992","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.2903\/j.efsa.2023.7911_ref23","first-page":"85","article-title":"Nephrocalcinosis in the rat: a literature review","volume":"16","author":"Ritskes\u2010Hoitinga","year":"1992","journal-title":"Progress in Food and Nutrition Science"},{"key":"10.2903\/j.efsa.2023.7911_ref24","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/cea.12260","article-title":"Glucoamylase is a major allergen of Schizophyllum commune","volume":"44","author":"Toyotome","year":"2014","journal-title":"Clinical and Experimental Allergy"}],"container-title":["EFSA Journal"],"original-title":[],"link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2903\/j.efsa.2023.7911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.2903\/j.efsa.2023.7911\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T16:07:26Z","timestamp":1683734846000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.2903\/j.efsa.2023.7911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":24,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2903\/j.efsa.2023.7911","relation":{},"ISSN":["1831-4732","1831-4732"],"issn-type":[{"value":"1831-4732","type":"print"},{"value":"1831-4732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}