{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:21:33Z","timestamp":1740115293813,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:p>Abstract\r\n Following a request from the European Commission, the EFSA was asked to deliver a scientific opinion on the renewal of the feed additive consisting of canthaxanthin (Carophyll\u00ae Red 10%) for breeder hens and to modify the additive specifications by substituting ethoxyquin by 4.4% butylated hydroxytoluene (BHT) and increasing the limit for dichloromethane to 80 mg\/kg. The additive complies with the conditions of the authorisation. The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) notes that the proposed modifications for the additive are considered to be of no concern. The Panel concluded that CAROPHYLL\u00aeRed 10% remains safe for the target species and the consumer under the current authorised conditions of use for CAROPHYLL\u00ae Red 10%. The Panel noted that the current maximum residue limits (MRLs) set in the different authorisations for canthaxanthin may not be protective enough for the consumer when considering combined exposure by all possible routes. CAROPHYLL\u00ae Red 10% should be considered to be irritant to skin and eyes and the respiratory tract and to be a skin sensitiser; any exposure is considered a risk. In the absence of data, the Panel could not conclude whether the additive CAROPHYLL\u00ae Red 10% remains safe for the environment under the current conditions of the authorisation. There is no need for assessing the efficacy of the additive in the context of the renewal of the authorisation. \r\n<\/jats:p>","DOI":"10.2903\/j.efsa.2025.9253","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T10:02:32Z","timestamp":1740045752000},"source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the feed additive consisting of canthaxanthin (Carophyll\u00ae Red 10%) for breeder hens for the renewal of its authorisation (DSM Nutritional Products Ltd.)"],"prefix":"10.2903","volume":"23","author":[{"name":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Edoardo","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Azimonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Bonos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojca","family":"Durjava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boet","family":"Glandorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryline","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"L\u00f3pez\u2010Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Nebbia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Pechov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Prieto\u2010Maradona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilen","family":"R\u00f6he","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Theodoridou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Galobart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsolya","family":"Holczknecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Navarro\u2010Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Pizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Vettori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2025.9253_ref1","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2007). Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) on a request from the European Commission on safety and efficacy of Panaferd\u2010AX (red carotenoid\u2010richbacterium Paracoccus carotinifaciens) as feed additive for salmon and trout. EFSA Journal, 546. https:\/\/doi.org\/10.2903\/j.efsa.2007.546","DOI":"10.2903\/j.efsa.2007.546"},{"key":"10.2903\/j.efsa.2025.9253_ref2","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2008). Technical Guidance of the scientific panel on additives and products or substances used in animal feed (FEEDAP) for assessing the safety of feed additives for the environment. EFSA Journal, 6(10), 842. https:\/\/doi.org\/10.2903\/j.efsa.2008.842","DOI":"10.2903\/j.efsa.2008.842"},{"key":"10.2903\/j.efsa.2025.9253_ref3","doi-asserted-by":"crossref","unstructured":"EFSA ANS Panel (EFSA Panel on Food Additives and Nutrient Sources added to Food) . (2010). Scientific Opinion on the reevaluation of canthaxanthin (E 161 g) as a food additive. EFSA Journal, 8(10), 1852. https:\/\/doi.org\/10.2903\/j.efsa.2010.1852","DOI":"10.2903\/j.efsa.2010.1852"},{"key":"10.2903\/j.efsa.2025.9253_ref4","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2013). Scientific opinion on the safety and efficacy of CAROPHYLL\u00ae Red 10% (preparation of canthaxanthin) for all poultry for breeding purposes (chickens, turkeys and other poultry). EFSA Journal, 11(1), 3047. https:\/\/doi.org\/10.2903\/j.efsa.2013.3047","DOI":"10.2903\/j.efsa.2013.3047"},{"key":"10.2903\/j.efsa.2025.9253_ref5","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2014). Scientific opinion on the safety and efficacy of canthaxanthin as a feed additive for poultry and for ornamental birds and ornamental fish. EFSA Journal, 12(1), 3527. https:\/\/doi.org\/10.2903\/j.efsa.2014.3527","DOI":"10.2903\/j.efsa.2014.3527"},{"key":"10.2903\/j.efsa.2025.9253_ref6","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Rychen, G., Aquilina, G., Azimonti, G., Bampidis, V., Bastos, M. D. L., Bories, G., Chesson, A., Cocconcelli, P. S., Flachowsky, G., Gropp, J., Kolar, B., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Mantovani, A., Mayo, B., Ramos, F., & Innocenti, M. L. (2017). Guidance on the assessment of the safety of feed additives for the consumer. EFSA Journal, 15(10), 5022. https:\/\/doi.org\/10.2903\/j.efsa.2017.5022","DOI":"10.2903\/j.efsa.2017.5022"},{"key":"10.2903\/j.efsa.2025.9253_ref7","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Bastos, M., Christensen, H., Dusemund, B., Kouba, M., Kos Durjava, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Marcon, F., Mayo, B., Pechov\u00e1, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Brock, T., de Knecht, J., \u2026 Azimonti, G. (2019). Guidance on the assessment of the safety of feed additives for the environment. EFSA Journal, 17(4), 5648. https:\/\/doi.org\/10.2903\/j.efsa.2019.5648","DOI":"10.2903\/j.efsa.2019.5648"},{"key":"10.2903\/j.efsa.2025.9253_ref8","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. 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Modification of the terms of authorisation of the feed additive consisting of a preparation of canthaxanthin (CAROPHYLL\u00ae Red 10%) for breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.). EFSA Journal, 23(1), 9133. https:\/\/doi.org\/10.2903\/j.efsa.2025.9133","DOI":"10.2903\/j.efsa.2025.9133"},{"key":"10.2903\/j.efsa.2025.9253_ref10","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Villa, R. E., Azimonti, G., Bonos, E., Christensen, H., Durjava, M., Dusemund, B., Gehring, R., Glandorf, B., Kouba, M., L\u00f3pez\u2010Alonso, M., Marcon, F., Nebbia, C., Pechov\u00e1, A., Prieto\u2010Maradona, M., R\u00f6he, I., Theodoridou, K., Bastos, M., Bories, G., & Vettori, M. V. (2025b). Modification of the terms of authorisation of the feed additive consisting of canthaxanthin for chickens for fattening, minor poultry species for fattening, laying poultry and poultry reared for laying, ornamental fish and ornamental birds and ornamental breeder hens to include canthaxanthin produced with Yarrowia lipolytica CBS 146148 (DSM Nutritional Products Ltd.). EFSA Journal, 23(1), 9134. https:\/\/doi.org\/10.2903\/j.efsa.2025.9134","DOI":"10.2903\/j.efsa.2025.9134"},{"key":"10.2903\/j.efsa.2025.9253_ref11","unstructured":"VICH (International Cooperation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products) . (2023). 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