{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:06:04Z","timestamp":1789499164979,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:p>Abstract\r\n According to the \u2018EFSA\u2010SANTE Action Plan on Cumulative Risk Assessment for pesticides residues\u2019, EFSA initiated a retrospective cumulative risk assessment (CRA) of the effects of pesticide residues on the liver. For this CRA, EFSA identified the following liver\u2010specific effects in accordance with the International Harmonisation of Nomenclature and Diagnostic Criteria (INHAND): (1) hypertrophy due to enzymatic induction, liver; (2) fatty change and\/or phospholipidosis, hepatocellular; (3) degeneration\/cell death, hepatocellular; (4) porphyria, hepatocellular, biliary duct; (5) cholestasis, hepatocellular, biliary duct; (6) preneoplastic and neoplastic changes, hepatocellular; (7) neoplastic changes, biliary duct. In addition, as gallbladder is part of the extrahepatic biliary system and can be affected by hepatic toxicity, the following specific effects in the gallbladder were defined: (1) erosion\/ulceration, gallbladder (2) calculi, gallbladder and (3) neoplastic changes, gallbladder. Histopathology was considered as the most appropriate source of evidence together with the increase in relative liver weight, and a list of indicators was defined and will be used to collect information on these specific effects as included in the assessment reports of the different active substances used as plant protection products. The criteria for inclusion of active substances\/metabolites into cumulative assessment groups (CAGs) were also defined, together with the hazard characterisation methodology and the lines of evidence for assessing CAG\u2010membership probabilities. While primary indicators define the specific effect, secondary indicators and other endpoints (named ancillary endpoints) are considered not sufficiently informative to indicate a specific effect but are rather contributing to the overall evidence; these will be collected only for a limited number of substances (i.e. risk drivers based on hazard and exposure considerations) for determining the likelihood of the substances truly belonging to the CAGs (CAG\u2010membership probabilities). Considering that it is not considered appropriate to establish CAGs for acute liver effects, CRAs on the liver will be only focused on chronic exposure. The process of data extraction and actual establishment of the CAGs is beyond the scope of this report. This part of the CRA process was outsourced and will be the subject of a separate report. \r\n<\/jats:p>","DOI":"10.2903\/j.efsa.2025.9409","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T09:08:52Z","timestamp":1746436132000},"source":"Crossref","is-referenced-by-count":6,"title":["Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues"],"prefix":"10.2903","volume":"23","author":[{"name":"European Food Safety Authority (EFSA)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna F.","family":"Castoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Coja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lanzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriaki","family":"Machera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Mohimont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Nepal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Recordati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Crivellente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"3","key":"10.2903\/j.efsa.2025.9409_ref1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1939-165X.2005.tb00041.x","article-title":"Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studies","volume":"34","author":"Boone","year":"2005","journal-title":"Veterinary Clinical Pathology"},{"key":"10.2903\/j.efsa.2025.9409_ref2","first-page":"125","volume-title":"Fundamentals of Toxicologic pathology","author":"Wallig","year":"2018"},{"key":"10.2903\/j.efsa.2025.9409_ref3","doi-asserted-by":"crossref","unstructured":"Chang, Z., Guan, J.\u2010X., Hui, D.\u2010Y., Zhang, N.\u2010N., Lu, L.\u2010R., Tang, L.\u2010Y., Shao, C.\u2010K., & Chen, J.\u2010N. 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