{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:05:49Z","timestamp":1749182749821,"version":"3.41.0"},"reference-count":5,"publisher":"Wiley","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Abstract\r\n Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of copper(II)\u2010betaine complex as a nutritional feed additive for all species and categories. In a previous opinion, the FEEDAP Panel characterised the feed additive and concluded that it is safe for the target animals, consumers, and the environment when used up to the maximum authorised levels of copper in the diets. With regard to the safety of users, the additive is considered irritant to the eyes and a skin and respiratory sensitiser. In the current submission, the applicant provided a new efficacy study in chickens for fattening to support the efficacy of the additive. The data submitted provided evidence that the additive is a bioavailable source of copper and thus, the FEEDAP Panel concludes that the additive is efficacious as a source of copper for all animal species. \r\n<\/jats:p>","DOI":"10.2903\/j.efsa.2025.9469","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:23:50Z","timestamp":1749115430000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of a feed additive consisting of a copper(II)\u2010betaine complex for all animal species (Biochem Zusatzstoffe Handels\u2010 und Produktionsges. mbH)"],"prefix":"10.2903","volume":"23","author":[{"name":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Edoardo","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Azimonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Bonos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojca","family":"Durjava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boet","family":"Glandorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryline","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"L\u00f3pez\u2010Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Nebbia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Pechov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Prieto\u2010Maradona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilen","family":"R\u00f6he","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Theodoridou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Galobart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Vettori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Navarro\u2010Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2025.9469_ref1","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2024). EFSA statement on the requirements for whole genome sequence analysis of microorganisms intentionally used in the food chain. EFSA Journal, 22(8), 8912. https:\/\/doi.org\/10.2903\/j.efsa.2024.8912","DOI":"10.2903\/j.efsa.2024.8912"},{"key":"10.2903\/j.efsa.2025.9469_ref2","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2016). Scientific opinion on the revision of the currently authorised maximum copper content in complete feed. EFSA Journal, 14(8), 4563. https:\/\/doi.org\/10.2903\/j.efsa.2016.4563","DOI":"10.2903\/j.efsa.2016.4563"},{"key":"10.2903\/j.efsa.2025.9469_ref3","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. L., Christensen, H., Dusemund, B., Durjava, M., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Marcon, F., Mayo, B., Pechov\u00e1, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Finizio, A., \u2026 Radovnikovic, A. (2023a). Scientific opinion on the safety and efficacy of a feed additive consisting of copper(II)\u2010betaine complex for all animal species (biochem Zusatzstoffe Handels\u2010und Produktionsges.mbH). EFSA Journal, 21(2), 7817. https:\/\/doi.org\/10.2903\/j.efsa.2023.7817","DOI":"10.2903\/j.efsa.2023.7817"},{"key":"10.2903\/j.efsa.2025.9469_ref4","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. L., Christensen, H., Durjava, M., Dusemund, B., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Marcon, F., Mayo, B., Pechov\u00e1, A., Petkova, M., Ramos, F., Villa, R. E., Woutersen, R., Galobart, J., Innocenti, M. L., \u2026 Radovnikovic, A. (2023b). Safety and efficacy of a feed additive consisting of copper(II)\u2010betaine complex for all animal species (Biochem Zusatzstoffe Handels\u2010 und Produktionsges. mbH). EFSA Journal, 21(11), 8460. https:\/\/doi.org\/10.2903\/j.efsa.2023.8460","DOI":"10.2903\/j.efsa.2023.8460"},{"key":"10.2903\/j.efsa.2025.9469_ref5","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. d. L., Christensen, H., Durjava, M., Dusemund, B., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Marcon, F., Mayo, B., Pechov\u00e1, A., Petkova, M., Ramos, F., Villa, R. E., Woutersen, R., Dierick, N., Bastos, M. L., \u2026 Ortu\u00f1o, J. (2024). Guidance on the assessment of the efficacy of feed additives. EFSA Journal, 22(7), 8856. https:\/\/doi.org\/10.2903\/j.efsa.2024.8856","DOI":"10.2903\/j.efsa.2024.8856"}],"container-title":["EFSA Journal"],"original-title":[],"link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2903\/j.efsa.2025.9469","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.2903\/j.efsa.2025.9469\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:23:51Z","timestamp":1749115431000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.2903\/j.efsa.2025.9469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":5,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.2903\/j.efsa.2025.9469","relation":{},"ISSN":["1831-4732","1831-4732"],"issn-type":[{"value":"1831-4732","type":"print"},{"value":"1831-4732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}