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No new data were received following the call for biological and toxicological data. A summary of the toxicological studies available in the EFSA opinion of 2007 is presented and studies gathered from the literature are summarised. Neotame is rapidly absorbed and pre\u2010systemically metabolised, systemic intact neotame is likely to be excreted in the urine with its metabolites. The potential aneugenic effects at the site of contact are not expected to occur; overall, there is no concern for genotoxicity of neotame (E 961) at the maximum permitted levels or reported use levels. A review of the other endpoints from the already available toxicological database did not indicate an adverse effect for neotame at the highest doses tested. The Panel established an acceptable daily intake (ADI) of 10 mg\/kg bw per day for neotame based on the no observed adverse effect level (NOAEL) of 1000 mg\/kg bw per day from a 52\u2010week chronic and 104\u2010week carcinogenicity studies in rats. This ADI replaces the ADI of 2 mg\/kg bw per day established by EFSA in 2007. The resulting exposure to methanol and its metabolite formaldehyde from the use of neotame at the ADI of 10 mg\/kg bw per day does not raise a concern. The dietary exposure estimates of neotame (E 961) for the different population groups of all exposure scenarios did not exceed the ADI. The Panel concluded that there is no safety concern for neotame (E 961) at the currently permitted and reported uses and use levels. The Panel recommended the European Commission to consider revising the EU specifications of neotame (E 961).<\/jats:p>","DOI":"10.2903\/j.efsa.2025.9480","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T09:50:11Z","timestamp":1751622611000},"source":"Crossref","is-referenced-by-count":5,"title":["Re\u2010evaluation of neotame (E 961) as food additive"],"prefix":"10.2903","volume":"23","author":[{"name":"EFSA Panel on Food Additives and Flavourings (FAF)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Castle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Andreassen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Aquilina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria 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