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The point estimate of the relative potency (ratio \u03949\u2010THC\/\u03948\u2010THC) was in the range between 1 and 1.4, with 95% confidence between 0.97 and 1.63. Based on this range, the CONTAM Panel, using a conservative approach, set a relative potency factor of one for \u03948\u2010THC. The CONTAM Panel had previously set an acute reference dose (ARfD) of 1 \u03bcg\/kg body weight for \u03949\u2010THC derived from adverse effects on human central nervous system (CNS). Given the similarity in the effects and the mode of action between \u03948\u2010THC and \u03949\u2010THC, the Panel considered that the established ARfD can be considered as a group ARfD for the sum of \u03948\u2010 and \u03949 THC. Regarding the occurrence of \u03948\u2010THC, the majority of samples were left censored, in particular for hemp infusion leaves, hemp seed oil and hemp seeds (96%\u201399%). Highest detection rates and levels were found in the categories \u2018Sugar and similar, confectionery and water\u2010based sweet desserts\u2019 and \u2018Products for non\u2010standard diets, food imitates and food supplements\u2019. Of 1145 samples, both substances were detected together in only 96 samples. If the two substances are produced naturally, a \u03948\u2010THC to \u03949\u2010THC ratio below 1 is expected; however, many of the samples, positive for \u03948\u2010THC, were above this ratio indicating either addition of semi\u2010synthetic \u03948\u2010THC, formation during processing or enrichment of the natural \u03948\u2010THC.<\/jats:p>","DOI":"10.2903\/j.efsa.2025.9735","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T10:17:29Z","timestamp":1763461049000},"source":"Crossref","is-referenced-by-count":2,"title":["Derivation of a health\u2010based guidance value for \u03948\u2010tetrahydrocannabinol (\u03948\u2010THC) and its occurrence in food"],"prefix":"10.2903","volume":"23","author":[{"name":"EFSA Panel on Contaminants in the Food Chain (CONTAM)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle 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