{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T08:04:25Z","timestamp":1780041865843,"version":"3.53.1"},"reference-count":12,"publisher":"Wiley","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:p>Abstract The applicant Corteva Agriscience International S\u00e0rl submitted a request to the competent national authority in Sweden to evaluate the confirmatory data that were identified for isoxaben in the framework of the maximum residue level (MRL) review under Article 12 of Regulation (EC) No 396\/2005 as not available. To address the data gaps, a new analytical method for enforcement and its independent laboratory validation (ILV), plus additional studies on the magnitude of residues were submitted by the applicant. The outstanding data gaps were sufficiently addressed. The new information provided confirmed a no\u2010residue situation in cotton seed and herbal infusions from flowers. The current MRL of 0.01 mg\/kg for cotton seeds can therefore be confirmed. Since a more sensitive analytical enforcement method is now available, a lowering of the existing MRLs (0.05 mg\/kg) for herbal infusions (flowers and roots) and hops to an limit of quantification (LOQ) of 0.01 mg\/kg can be considered. The updated exposure calculations did not indicate a risk to consumers health.<\/jats:p>","DOI":"10.2903\/j.efsa.2026.10084","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:35:02Z","timestamp":1778160902000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of confirmatory data following the Article 12 MRL review for isoxaben"],"prefix":"10.2903","volume":"24","author":[{"name":"European Food Safety Authority (EFSA)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bellisai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Carrasco Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Castellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"del Aguila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucien","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Leuschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mio\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Nave","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermine","family":"Reich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ruocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia Pia","family":"Scarlato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Szot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Theobald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tiramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Verani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zioga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2026.10084_ref1","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2010). Conclusion on the peer review of the pesticide risk assessment of the active substance isoxaben. EFSA Journal, 8(9), 1714. https:\/\/doi.org\/10.2903\/j.efsa.2010.1714","DOI":"10.2903\/j.efsa.2010.1714"},{"key":"10.2903\/j.efsa.2026.10084_ref2","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) , Brancato, A., Brocca, D., Ferreira, L., Greco, L., Jarrah, S., Leuschner, R., Medina, P., Miron, I., Nougadere, A., Pedersen, R., Reich, H., Santos, M., Stanek, A., Tarazona, J., Theobald, A., & Villamar\u2010Bouza, L. (2018). Guidance on use of EFSA Pesticide Residue Intake Model (EFSA PRIMo revision 3). EFSA Journal, 16(1), 5147. https:\/\/doi.org\/10.2903\/j.efsa.2018.5147","DOI":"10.2903\/j.efsa.2018.5147"},{"key":"10.2903\/j.efsa.2026.10084_ref3","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) , Anastassiadou, M., Brancato, A., Carrasco Cabrera, L., Ferreira, L., Greco, L., Jarrah, S., Kazocina, A., Leuschner, R., Magrans, J. O., Miron, I., Pedersen, R., Raczyk, M., Reich, H., Ruocco, S., Sacchi, A., Santos, M., Stanek, A., Tarazona, J., \u2026 Verani, A. (2019). Pesticide residue intake model\u2010 EFSA PRIMo revision 3.1 (update of EFSA PRIMo revision 3). EFSA Supporting Publications, 16, EN\u20101605. https:\/\/doi.org\/10.2903\/sp.efsa.2019.EN\u20101605","DOI":"10.2903\/sp.efsa.2019.EN-1605"},{"key":"10.2903\/j.efsa.2026.10084_ref4","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2022). Reasoned opinion on the review of the existing maximum residue levels for isoxaben according to article 12 of regulation (EC) No 396\/2005. EFSA Journal, 20(1), 7062. https:\/\/doi.org\/10.2903\/j.efsa.2022.7062","DOI":"10.2903\/j.efsa.2022.7062"},{"key":"10.2903\/j.efsa.2026.10084_ref5","unstructured":"European Commission . (2011). Review report for the active substance isoxaben. Finalised in the Standing Committee on the Food Chain and Animal Health at its meeting on 28 January 2011 in view of the inclusion of isoxaben in Annex I of Council Directive 91\/414\/EEC and revised on 17 July 2020. SANCO\/12826\/2010\u2010Finalrev. 2, 17 July 2020."},{"key":"10.2903\/j.efsa.2026.10084_ref6","unstructured":"European Commission . (2020). Review report for the active substance isoxaben. Finalised in the Standing Committee on the Food Chain and Animal Health at its meeting on 28 January 2011 in view of the inclusion of isoxaben in Annex I of Council Directive 91\/414\/EEC and revised on 17 July 2020. SANCO\/12826\/2010\u2010Final rev. 2, 17 July 2020."},{"key":"10.2903\/j.efsa.2026.10084_ref7","unstructured":"European Commission . (2023a). Guidance Document on Pesticide Analytical Methods for Risk Assessment and Post\u2010approval Control and Monitoring Purposes. SANTE\/2020\/12830. Rev.2 14 February 2023."},{"key":"10.2903\/j.efsa.2026.10084_ref8","unstructured":"European Commission . (2023b). Technical guideline on the evaluation of extraction efficiency of residue analytical methods. SANTE 2017\/10632, Rev. 5, 11 May 2023."},{"key":"10.2903\/j.efsa.2026.10084_ref9","unstructured":"European Commission . (2023c). 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