{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:01:59Z","timestamp":1792202519435,"version":"4.4.0"},"reference-count":6,"publisher":"Wiley","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit\u00ae Extra) as a zootechnical feed additive for suckling and weaned piglets and other growing Suidae. In its previous assessment, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) had no safety concerns for the target species when the additive is used at the recommended level of 0.750 mg sanguinarine\/kg complete feed for suckling and weaned piglets and other growing Suidae. However, owing to the presence of the DNA intercalators sanguinarine and chelerythrine, a concern for genotoxicity was identified for the additive and the FEEDAP Panel could not conclude on the safety for the consumer. The use of the additive was considered safe for the environment. The additive was shown to be irritant to the eyes but not irritant to skin or a skin sensitiser. In the current assessment, the applicant provided an in\u00a0vitro mutagenicity assay in mammalian cells with Macleaya cordata extract. Although the study gave negative results, these would not change the conclusions on the genotoxicity of sanguinarine and chelerythrine reached in the previous assessment. Therefore, the FEEDAP Panel cannot conclude on the safety of Sangrovit\u00ae Extra for consumers when used in feed for suckling and weaned piglets and other growing Suidae.<\/jats:p>","DOI":"10.2903\/j.efsa.2026.10252","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:08:32Z","timestamp":1784632112000},"source":"Crossref","is-referenced-by-count":1,"title":["Safety of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit\u00ae Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH)"],"prefix":"10.2903","volume":"24","author":[{"name":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Edoardo","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Azimonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Bonos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojca","family":"Durjava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boet","family":"Glandorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryline","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"L\u00f3pez\u2010Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Nebbia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Pechov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Prieto\u2010Maradona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Theodoridou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Lourdes","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Benfenati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Brantom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Chesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Schlatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Westendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Manini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2026.10252_ref1","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Rychen, G., Aquilina, G., Azimonti, G., Bampidis, V., Bastos, M. d. L., Bories, G., Chesson, A., Cocconcelli, P. S., Flachowsky, G., Gropp, J., Kolar, B., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Mantovani, A., Mayo, B., Ramos, F., \u2026 Innocenti, M. L. (2017). Guidance on the assessment of the safety of feed additives for the consumer. EFSA Journal, 15(10), 5022. https:\/\/doi.org\/10.2903\/j.efsa.2017.5022","DOI":"10.2903\/j.efsa.2017.5022"},{"key":"10.2903\/j.efsa.2026.10252_ref2","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2021). General approach to assess the safety for the target species of botanical preparations which contain compounds that are genotoxic and\/or carcinogenic. EFSA Journal https:\/\/www.efsa.europa.eu\/sites\/default\/files\/2021\u201005\/general\u2010approach\u2010assessment\u2010botanical\u2010preparations\u2010containing\u2010genotoxic\u2010carcinogenic\u2010compounds.pdf"},{"key":"10.2903\/j.efsa.2026.10252_ref3","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. L., Christensen, H., Dusemund, B., Durjava, M. F., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Marcon, F., Mayo, B., Pechov\u00e1, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Brantom, P., \u2026 Dusemund, B. (2023). Scientific opinion on the safety and efficacy of a feed additive consisting of Macleaya cordata (Willd.) R. Br. Extract and leaves (Sangrovit\u00ae extra) for all poultry species (excluding laying and breeding birds) (Phytobiotics Futterzusatzstoffe GmbH). 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