{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:09:26Z","timestamp":1790334566083,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Abstract The food enzyme endo\u20101,4\u2010\u03b2\u2010xylanase (4\u2010\u03b2\u2010d\u2010xylan xylanohydrolase, EC 3.2.1.8) is produced with the genetically modified Aspergillus oryzae strain NZYM\u2010FA by Novozymes A\/S. The safety of this food enzyme was evaluated previously, and it did not give rise to safety concerns when used in two food manufacturing processes. Subsequently, the applicant has requested to extend its use to include two additional processes. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of four food manufacturing processes. The dietary exposure to the food enzyme\u2013Total Organic Solids (TOS) was calculated to be up to 0.031 mg TOS\/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (1101.3 mg TOS\/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 35,526. Based on the revised exposure estimation, the newly derived margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.<\/jats:p>","DOI":"10.2903\/j.efsa.2026.10335","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:30:19Z","timestamp":1790332219000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety evaluation of an extension of use of the food enzyme endo\u20101,4\u2010\u03b2\u2010xylanase from the genetically modified Aspergillus oryzae strain NZYM\u2010FA"],"prefix":"10.2903","volume":"24","author":[{"name":"EFSA Panel on Food Enzymes (FEZ)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Barat Baviera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Catania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Gadermaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baltasar","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yrj\u00f6 Henrik","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marize L. 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(2006). Opinion of the Scientific Committee related to uncertainties in dietary exposure assessment. EFSA Journal, 5(1), 438. https:\/\/doi.org\/10.2903\/j.efsa.2007.438","DOI":"10.2903\/j.efsa.2007.438"},{"key":"10.2903\/j.efsa.2026.10335_ref2","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2009). Guidance of the Scientific Committee on transparency in the scientific aspects of risk assessments carried out by EFSA. Part 2: General principles. EFSA Journal, 7(5), 1051. https:\/\/doi.org\/10.2903\/j.efsa.2009.1051","DOI":"10.2903\/j.efsa.2009.1051"},{"key":"10.2903\/j.efsa.2026.10335_ref3","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2011). Use of the EFSA comprehensive European food consumption database in exposure assessment. 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