{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:53:58Z","timestamp":1791453238556,"version":"4.3.3"},"reference-count":6,"publisher":"Wiley","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>Abstract The food enzyme non\u2010reducing end \u03b1\u2010l\u2010arabinofuranosidase (\u03b1\u2010l\u2010arabinofuranoside non\u2010reducing end \u03b1\u2010l\u2010arabinofuranosidase; EC 3.2.1.55) is produced with the genetically modified Trichoderma reesei strain NZYM\u2010GV by Novozymes A\/S. The safety of this food enzyme was evaluated previously, and it did not give rise to safety concerns when used in one food manufacturing process. Subsequently, the applicant has requested to extend its use to include one additional process. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of two food manufacturing processes. As the food enzyme\u2013Total Organic Solids (TOS) are removed in one process, the dietary exposure to the food enzyme\u2013TOS was estimated for the remaining food manufacturing process. It was calculated to be up to 0.009 mg TOS\/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (1116 mg TOS\/kg bw per day, the highest dose tested), the Panel derived a margin of exposure (MOE) of at least 124,000. Based on the new data, the revised MOE and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.<\/jats:p>","DOI":"10.2903\/j.efsa.2026.10340","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:30:33Z","timestamp":1791451833000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety evaluation of an extension of use of the food enzyme non\u2010reducing end \u03b1\u2010l\u2010arabinofuranosidase from the genetically modified Trichoderma reesei strain NZYM\u2010GV"],"prefix":"10.2903","volume":"24","author":[{"name":"EFSA Panel on Food Enzymes (FEZ)","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Barat Baviera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Bolognesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Catania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Gadermaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baltasar","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yrj\u00f6 Henrik","family":"Roos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marize L. M.","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk","family":"Van Loveren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Vernis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Cavanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Toki\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2026.10340_ref1","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2006). Opinion of the Scientific Committee related to uncertainties in dietary exposure assessment. EFSA Journal, 5(1), 438. https:\/\/doi.org\/10.2903\/j.efsa.2007.438","DOI":"10.2903\/j.efsa.2007.438"},{"key":"10.2903\/j.efsa.2026.10340_ref2","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2009). Guidance of the Scientific Committee on transparency in the scientific aspects of risk assessments carried out by EFSA. Part 2: General principles. EFSA Journal, 7(5), 1051. https:\/\/doi.org\/10.2903\/j.efsa.2009.1051","DOI":"10.2903\/j.efsa.2009.1051"},{"key":"10.2903\/j.efsa.2026.10340_ref3","doi-asserted-by":"crossref","unstructured":"EFSA (European Food Safety Authority) . (2011). Use of the EFSA comprehensive European food consumption database in exposure assessment. EFSA Journal, 9(3), 2097. https:\/\/doi.org\/10.2903\/j.efsa.2011.2097","DOI":"10.2903\/j.efsa.2011.2097"},{"key":"10.2903\/j.efsa.2026.10340_ref4","doi-asserted-by":"crossref","unstructured":"EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes and Processing Aids) , Lambr\u00e9, C., Barat Baviera, J. M., Bolognesi, C., Cocconcelli, P. S., Crebelli, R., Gott, D. M., Grob, K., Lampi, E., Mengelers, M., Mortensen, A., Rivi\u00e8re, G., Steffensen, I.\u2010L., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Glandorf, B., Herman, L., \u2026 Chesson, A. (2021). Scientific Guidance for the submission of dossiers on food enzymes. EFSA Journal, 19(10), 6851. https:\/\/doi.org\/10.2903\/j.efsa.2021.6851","DOI":"10.2903\/j.efsa.2021.6851"},{"key":"10.2903\/j.efsa.2026.10340_ref5","doi-asserted-by":"crossref","unstructured":"EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes and Processing Aids) , Lambr\u00e9, C., Barat Baviera, J. M., Bolognesi, C., Cocconcelli, P. S., Crebelli, R., Gott, D. M., Grob, K., Lampi, E., Mengelers, M., Mortensen, A., Rivi\u00e8re, G., Steffensen, I.\u2010L., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Andryszkiewicz, M., Liu, Y., \u2026 Chesson, A. (2022). Scientific Opinion on the safety evaluation of the food enzyme non\u2010reducing end \u03b1\u2010l\u2010arabinofuranosidase from the genetically modified Trichoderma reesei strain NZYM\u2010GV. EFSA Journal, 20(3), 7173. https:\/\/doi.org\/10.2903\/j.efsa.2022.7173","DOI":"10.2903\/j.efsa.2022.7173"},{"key":"10.2903\/j.efsa.2026.10340_ref6","doi-asserted-by":"crossref","unstructured":"EFSA CEP Panel (EFSA Panel on Food Contact Materials, Enzymes, Processing Aids) , Lambr\u00e9, C., Barat Baviera, J. M., Bolognesi, C., Cocconcelli, P. S., Crebelli, R., Gott, D. M., Grob, K., Lampi, E., Mengelers, M., Mortensen, A., Rivi\u00e8re, G., Steffensen, I.\u2010L., Tlustos, C., van Loveren, H., Vernis, L., Zorn, H., Roos, Y., Apergi, K., \u2026 Chesson, A. (2023). 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