{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T10:08:39Z","timestamp":1771236519938,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin E in the forms of tocopherol extracts from vegetable oils, tocopherol\u2010rich extracts from vegetable oils (delta rich) and alpha\u2010tocopherol, as technological feed additives for all animal species. The additives are already authorised for use in all animal species without a specified minimum or maximum level. The applicant provided evidence that the additives currently on the market comply with the existing conditions of authorisation. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additives remain safe for the target species, the consumer and the environment. Regarding user safety, the additives should be considered skin and respiratory sensitisers. Exposure of users by inhalation and dermal routes is considered a risk. The FEEDAP Panel cannot conclude on the eye irritation potential due to the lack of data. There is no need to assess the efficacy of the additives in the context of the renewal of the authorisation.<\/jats:p>","DOI":"10.2903\/j.efsa.2026.9917","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:19:47Z","timestamp":1771233587000},"source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the feed additives tocopherol extracts from vegetable oils (1b306(i)), tocopherol\u2010rich extracts from vegetable oils (delta rich) (1b306(ii)) and alpha\u2010tocopherol (1b307) for all animal species for the renewal of their authorisation (ADM International S\u00e0rl, DSM Nutritional Products Ltd., Europe\u2010Asia Import Export GmbH., Vitiva d.o.o., Kaesler Nutrition GmbH, Kemin Nutrisurance Europe SRL, LUCTA S.A., Vitae Caps S.A.U\/Kensing)"],"prefix":"10.2903","volume":"24","author":[{"name":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Edoardo","family":"Villa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Azimonti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios","family":"Bonos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mojca","family":"Durjava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Dusemund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronette","family":"Gehring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boet","family":"Glandorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryline","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"L\u00f3pez\u2010Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Marcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Nebbia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Pechov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Prieto\u2010Maradona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Theodoridou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Galobart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Manini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piera","family":"Valeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Vittoria","family":"Vettori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Pizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"10.2903\/j.efsa.2026.9917_ref1","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2010). Scientific opinion on the safety and efficacy of vitamin E as a feed additive for all animal species. EFSA Journal, 8(6), 1635. https:\/\/doi.org\/10.2903\/j.efsa.2010.1635","DOI":"10.2903\/j.efsa.2010.1635"},{"key":"10.2903\/j.efsa.2026.9917_ref2","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2012a). Scientific Opinion on the safety and efficacy of synthetic alpha\u2010tocopherol for all animal species. EFSA Journal, 10(7), 2784, 10 pp. https:\/\/doi.org\/10.2903\/j.efsa.2012.2784","DOI":"10.2903\/j.efsa.2012.2784"},{"key":"10.2903\/j.efsa.2026.9917_ref3","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) . (2012b). Scientific Opinion on the safety and efficacy of tocopherol\u2010rich extracts of natural origin, tocopherol\u2010rich extracts of natural origin\/delta\u2010rich, synthetic tocopherol for all animal species. EFSA Journal, 10(7), 2783, 14 pp. https:\/\/doi.org\/10.2903\/j.efsa.2012.2783","DOI":"10.2903\/j.efsa.2012.2783"},{"key":"10.2903\/j.efsa.2026.9917_ref4","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Rychen, G., Aquilina, G., Azimonti, G., Bampidis, V., Bastos, M. L., Bories, G., Chesson, A., Cocconcelli, P. S., Flachowsky, G., Gropp, J., Kolar, B., Kouba, M., Lopez\u2010Alonso, M., Lopez Puente, S., Mantovani, A., Mayo, B., Ramos, F., Saarela, M., \u2026 Innocenti, M. L. (2017). Guidance on the assessment of the safety of feed additives for the consumer. EFSA Journal, 15(10), 5022. https:\/\/doi.org\/10.2903\/j.efsa.2017.5022","DOI":"10.2903\/j.efsa.2017.5022"},{"key":"10.2903\/j.efsa.2026.9917_ref5","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. d. L., Christensen, H., Dusemund, B., Fa\u0161mon Durjava, M., Kouba, M., L\u00f3pez\u2010Alonso, M., L\u00f3pez Puente, S., Marcon, F., Mayo, B., Pechov\u00e1, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Anguita, M., \u2026 Innocenti, M. L. (2021a). Guidance on the renewal of the authorisation of feed additives. EFSA Journal, 19(1), 6340. https:\/\/doi.org\/10.2903\/j.efsa.2021.6340","DOI":"10.2903\/j.efsa.2021.6340"},{"key":"10.2903\/j.efsa.2026.9917_ref6","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. L., Christensen, H., Dusemund, B., Durjava, M. F., Kouba, M., Lopez\u2010Alonso, M., Lopez Puente, S., Marcon, F., Mayo, B., Pechova, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Bories, G., \u2026 Pizzo, F. (2021b). Scientific opinion on the assessment of a feed additive consisting of all\u2010rac\u2010alpha tocopheryl acetate (vitamin E) for all animal species for the renewal of its authorisation (DSM). EFSA Journal, 19(4), 6529. https:\/\/doi.org\/10.2903\/j.efsa.2021.6529","DOI":"10.2903\/j.efsa.2021.6529"},{"key":"10.2903\/j.efsa.2026.9917_ref7","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. L., Christensen, H., Dusemund, B., Fasmon Durjava, M., Kouba, M., Lopez\u2010Alonso, M., Lopez Puente, S., Marcon, F., Mayo, B., Pechova, A., Petkova, M., Ramos, F., Sanz, Y., Edoardo Villa, R., Woutersen, R., Bories, G., \u2026 Pizzo, F. (2021c). Scientific opinion on the assessment of afeed additive consisting of all\u2010rac\u2010alpha\u2010tocopheryl acetate (vitamin E) for all animal species for the renewal of its authorisation (Jilin Beisha pharmaceutical Co., ltd). EFSA Journal, 19(12), 6974. https:\/\/doi.org\/10.2903\/j.efsa.2021.6974","DOI":"10.2903\/j.efsa.2021.6974"},{"key":"10.2903\/j.efsa.2026.9917_ref8","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. L., Christensen, H., Dusemund, B., Durjava, M. F., Kouba, M., Lopez\u2010Alonso, M., Lopez Puente, S., Marcon, F., Mayo, B., Pechova, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Bories, G., \u2026 Manini, P. (2021d). Scientific opinion on the assessment of a feed additive consisting of all\u2010rac\u2010alpha\u2010tocopheryl acetate (vitamin E) for all animal species for the renewal of its authorisation (NHU Europe GmbH). EFSA Journal, 19(4), 6533. https:\/\/doi.org\/10.2903\/j.efsa.2021.6533","DOI":"10.2903\/j.efsa.2021.6533"},{"key":"10.2903\/j.efsa.2026.9917_ref9","doi-asserted-by":"crossref","unstructured":"EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed) , Bampidis, V., Azimonti, G., Bastos, M. D. L., Christensen, H., Dusemund, B., Fasmon Durjava, M., Kouba, M., Lopez\u2010Alonso, M., Lopez Puente, S., Marcon, F., Mayo, B., Pechova, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Bories, G., \u2026 Pizzo, F. (2021e). Scientific opinion on the assessment of a feed additive consisting of RRR\u2010alpha\u2010tocopheryl acetate (vitamin E) for all animal species for the renewal of its authorisation (Specialty Ingredients (Europe) B.V. and Vitae Caps S.A.). EFSA Journal, 19(4), 6532. https:\/\/doi.org\/10.2903\/j.efsa.2021.6532","DOI":"10.2903\/j.efsa.2021.6532"},{"key":"10.2903\/j.efsa.2026.9917_ref10","doi-asserted-by":"crossref","unstructured":"EFSA NDA Panel (EFSA Panel on Nutrition, Novel Foods and Food Allergens) , Turck, D., Bohn, T., Castenmiller, J., de Henauw, S., Hirsch\u2010Ernst, K.\u2010I., Knutsen, H. K., Maciuk, A., Mangelsdorf, I., McArdle, H. J., Pentieva, K., Siani, A., Thies, F., Tsabouri, S., Vinceti, M., Traber, M. G., Vrolijk, M., Bercovici, C. M., de Sesmaisons Lecarr\u00e9, A., \u2026 Naska, A. (2024). Scientific opinion on the tolerable upper intake level for vitamin E. EFSA Journal, 22(8), 8953. https:\/\/doi.org\/10.2903\/j.efsa.2024.8953","DOI":"10.2903\/j.efsa.2024.8953"},{"key":"10.2903\/j.efsa.2026.9917_ref11","unstructured":"European Commission, SCF (Scientific Committee on Food) . (2003). Tolerable upper intake level of vitamin E. https:\/\/ec.europa.eu\/food\/fs\/sc\/scf\/out195_en.pdf"},{"key":"10.2903\/j.efsa.2026.9917_ref12","unstructured":"European Medicine Agency (EMA) , & Committee for Medicinal Products for Veterinary Use (CVMP) . (2023). \u201cVICH GL18(R2) Impurities: Residual solvents in new veterinary medicinal products, active substances and excipients (revision 2).\u201d. EMA\/CVMP\/VICH\/502\/1999."},{"key":"10.2903\/j.efsa.2026.9917_ref13","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1017\/S0021859615000052","article-title":"Effects of supplementing mid\u2010lactation dairy cows with seaweed and vitamin E on plasma and milk a\u2010tocopherol and antibody response to immunization","volume":"153","author":"Kidane","year":"2015","journal-title":"The Journal of Agricultural Science"},{"key":"10.2903\/j.efsa.2026.9917_ref14","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s10499-010-9409-5","article-title":"Growth, survival, and fatty acid composition of Indian white shrimp Fenneropenaeus indicus (Milne Edwards) fed diets containing different levels of vitamin E and lipid","volume":"19","author":"Ouraji","year":"2011","journal-title":"Aquaculture International"},{"key":"10.2903\/j.efsa.2026.9917_ref15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2527\/jas.2013-6334","article-title":"Effects of feeding diets containing highly peroxidized distillers dried grains with solubles and increasing vitamin E levels to wean \u2010finish pigs on growt performance, carcass characteristics, and pork fat composition","volume":"92","author":"Song","year":"2014","journal-title":"Journal of Animal Science"},{"issue":"2","key":"10.2903\/j.efsa.2026.9917_ref16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin\u2010like compounds","volume":"93","author":"Van den Berg","year":"2006","journal-title":"Toxicological Sciences"}],"container-title":["EFSA Journal"],"original-title":[],"link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.2903\/j.efsa.2026.9917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.2903\/j.efsa.2026.9917\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:19:49Z","timestamp":1771233589000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.2903\/j.efsa.2026.9917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":16,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2903\/j.efsa.2026.9917","relation":{},"ISSN":["1831-4732","1831-4732"],"issn-type":[{"value":"1831-4732","type":"print"},{"value":"1831-4732","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]}}}