{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:37:19Z","timestamp":1774611439887,"version":"3.50.1"},"reference-count":126,"publisher":"Wiley","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EFS2","EFSA Journal"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Abstract\r\n The EFSA Panel on Food Contact Materials (FCM) was requested by the European Commission to re\u2010evaluate the potential genotoxicity of styrene after oral exposure and its safety for use in plastic FCM with a specific migration limit (SML) of 40 \u03bcg\/kg food. A rigorous assessment of the in\u00a0vivo genotoxicity studies (i) provided by third parties, (ii) identified by a targeted literature search and (iii) reported in the 2019 IARC Monograph was performed. All studies were assessed for reliability and relevance and the results integrated in the weight of evidence. The results provided by reliable in\u00a0vivo oral genotoxicity studies, covering different genetic endpoints and target tissues, including liver, the primary site of metabolism, demonstrated that the oral administration of styrene in mice and rats up to the maximum tolerated dose (300 and 500 mg\/kg body weight (bw), respectively) did not induce genotoxic effects. The Panel concluded that there was no evidence that styrene is genotoxic following oral exposure. For substances demonstrated to be non\u2010genotoxic, according to the EFSA Note for Guidance for FCM, an SML up to 50 \u03bcg\/kg food would not be of safety concern. Consequently, the use of styrene in the manufacture of FCM respecting the SML of 40 \u03bcg\/kg food proposed by the European Commission is not of safety concern. \r\n<\/jats:p>","DOI":"10.2903\/j.efsa.2025.9473","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T09:09:10Z","timestamp":1749546550000},"source":"Crossref","is-referenced-by-count":3,"title":["Re\u2010assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials"],"prefix":"10.2903","volume":"23","author":[{"name":"EFSA Panel on Food Contact Materials (FCM)","sequence":"first","affiliation":[]},{"given":"Lambr\u00e9","family":"Claude","sequence":"additional","affiliation":[]},{"given":"Riccardo","family":"Crebelli","sequence":"additional","affiliation":[]},{"given":"Maria","family":"Da Silva","sequence":"additional","affiliation":[]},{"given":"Konrad","family":"Grob","sequence":"additional","affiliation":[]},{"given":"Evgenia","family":"Lampi","sequence":"additional","affiliation":[]},{"given":"Maria Rosaria","family":"Milana","sequence":"additional","affiliation":[]},{"given":"Marja","family":"Pronk","sequence":"additional","affiliation":[]},{"given":"Mario","family":"\u0160\u010detar","sequence":"additional","affiliation":[]},{"given":"Georgios","family":"Theodoridis","sequence":"additional","affiliation":[]},{"given":"Els","family":"Van Hoeck","sequence":"additional","affiliation":[]},{"given":"Nadia","family":"Waegeneers","sequence":"additional","affiliation":[]},{"given":"Claudia","family":"Bolognesi","sequence":"additional","affiliation":[]},{"given":"Emma","family":"Di Consiglio","sequence":"additional","affiliation":[]},{"given":"Marcel","family":"Mengelers","sequence":"additional","affiliation":[]},{"given":"Zainab","family":"Al Harraq","sequence":"additional","affiliation":[]},{"given":"Irene Mu\u00f1oz","family":"Pilar","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Rainieri","sequence":"additional","affiliation":[]},{"given":"Gilles","family":"Rivi\u00e8re","sequence":"additional","affiliation":[]}],"member":"311","reference":[{"issue":"2","key":"10.2903\/j.efsa.2025.9473_ref1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0027-5107(80)90203-1","article-title":"Chromosomal aberrations and sister\u2010chromatid exchanges in lymphocytes of men occupationally exposed to styrene in a plastic\u2010boat factory","volume":"73","author":"Andersson","year":"1980","journal-title":"Mutation Research"},{"issue":"1\u20134","key":"10.2903\/j.efsa.2025.9473_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10937404.2019.1633718","article-title":"Evaluation of potential health effects associated with occupational and environmental exposure to styrene\u2013an update [review]","volume":"22","author":"Banton","year":"2019","journal-title":"Journal of Toxicology and Environmental Health \u2010 Part B: Critical Reviews"},{"issue":"1","key":"10.2903\/j.efsa.2025.9473_ref3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0009-2797(82)90006-0","article-title":"Investigation of styrene in the liver perfusion\/cell culture system. 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