{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:27:53Z","timestamp":1786973273881,"version":"build-2736575974"},"reference-count":0,"publisher":"African Journal of Reproductive Health (AJRH)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJRH"],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:p>Ovarian cancer (OC) is a leading cause of gynecologic cancer-related mortality and is frequently diagnosed at advanced stages due to the absence of effective early detection tools. Epigenetic alterations, particularly DNA methylation, play a critical role in tumorigenesis and represent promising non-invasive biomarkers. This study investigated the methylation status of the ANKRD23 gene in OC and evaluated its diagnostic potential using peripheral blood samples. A total of 385 serous OC patients, 50 individuals with benign ovarian conditions, and 99 healthy controls were included. DNA methylation was assessed using methylation-sensitive restriction enzymes followed by real-time PCR. ANKRD23 methylation was significantly associated with clinical stage (p = 0.029), histological grade (p = 0.009), and ethnicity (p = 0.024). Moreover, methylation levels differed significantly among OC patients, benign cases, and healthy controls (p = 0.026). These findings support blood-based ANKRD23 methylation as a promising biomarker for non-invasive ovarian cancer diagnosis and risk stratification.<\/jats:p>","DOI":"10.29063\/ajrh2026\/v30i15.2","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:59:52Z","timestamp":1786971592000},"page":"16-25","source":"Crossref","is-referenced-by-count":0,"title":["DNA methylation of ANKRD23 as a novel biomarker for early diagnosis of ovarian cancer"],"prefix":"10.29063","volume":"30","author":[{"given":"Aydan","family":"Alizada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge S.","family":"Erdogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda K.","family":"Erciyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul C.","family":"Demirbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Pasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Dinc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u0131nar","family":"Saip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seref B.","family":"Tuncer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11599","published-online":{"date-parts":[[2026,8,31]]},"container-title":["AFRICAN JOURNAL OF REPRODUCTIVE HEALTH"],"original-title":[],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:59:53Z","timestamp":1786971593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajrh.info\/index.php\/ajrh\/article\/view\/7195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":0,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8,31]]},"published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.29063\/ajrh2026\/v30i15.2","relation":{},"ISSN":["1118-4841","2141-3606"],"issn-type":[{"value":"1118-4841","type":"print"},{"value":"2141-3606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}