{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:18:49Z","timestamp":1788189529426,"version":"build-2803163510"},"reference-count":0,"publisher":"African Journal of Reproductive Health (AJRH)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJRH"],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:p>This study aimed to evaluate the value of combined platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase detection in predicting recurrence risk among patients with recurrent pregnancy loss in early pregnancy. A retrospective case-control study was conducted among 305 patients with early pregnancy RPL from January 2024 to May 2025. Patients were divided into a pregnancy loss group (n=116) and a live birth group (n=189). Peripheral blood platelet distribution width, neutrophil-to-lymphocyte ratio, alanine aminotransferase, and related laboratory parameters were compared between the groups. Platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase levels were significantly higher in the pregnancy loss group than in the live birth group. Multivariate logistic regression identified platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase as independent risk factors for recurrent pregnancy loss. Receiver operating characteristic analysis showed that the combined platelet distribution width+neutrophil-to-lymphocyte ratio+alanine aminotransferase model had an area under the curve of 0.706, outperforming any single marker. These findings suggest that combined detection of platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase may provide a simple and effective tool for early risk stratification in patients with recurrent pregnancy loss, reflecting potential platelet activation, inflammatory immune imbalance, and hepatic metabolic stress.<\/jats:p>","DOI":"10.29063\/ajrh2026\/v30i16.7","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:00:10Z","timestamp":1788188410000},"page":"81-92","source":"Crossref","is-referenced-by-count":0,"title":["Predictive value of platelet distribution width, neutrophil-to-lymphocyte ratio, and alanine aminotransferase for recurrence of pregnancy loss in early gestation"],"prefix":"10.29063","volume":"30","author":[{"given":"Zhifang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11599","published-online":{"date-parts":[[2026,8,31]]},"container-title":["AFRICAN JOURNAL OF REPRODUCTIVE HEALTH"],"original-title":[],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:00:12Z","timestamp":1788188412000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajrh.info\/index.php\/ajrh\/article\/view\/7218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":0,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2026,8,31]]},"published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.29063\/ajrh2026\/v30i16.7","relation":{},"ISSN":["1118-4841","2141-3606"],"issn-type":[{"value":"1118-4841","type":"print"},{"value":"2141-3606","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}