{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:16:02Z","timestamp":1788383762993,"version":"build-2803163510"},"reference-count":10,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>Introducci\u00f3n: En muchos casos de alergia a medicamentos, es necesario realizar pruebas in vitro por diversos motivos. La PAB (prueba de activaci\u00f3n de bas\u00f3filos) es un arma \u00fatil en estos casos.\nReporte de caso: Se trata de un hombre de 37 a\u00f1os en tratamiento con undecanoato de testosterona relacionado a s\u00edndrome de Klinefelter; que al momento de la \u00faltima minsitraci\u00f3n de la dosis, el paciente sufri\u00f3 un choque anafil\u00e1ctico acompa\u00f1ado de s\u00edndrome de Kounis. Por la necesidad de seguir con el tratamiento con testosterona, decidimos recurrir a la PAB para el diagn\u00f3stico, y los resultados fueron concluyentes, se document\u00f3 positividad al aceite de ricino.\nConclusiones: A nivel mundial, este es el segundo caso de anafilaxia asociado a undecanoato de testosterona y el primero donde el aceite de ricino ha sido el responsable. La PAB se hizo necesaria para el diagn\u00f3stico y el posterior tratamiento de este paciente.<\/jats:p>","DOI":"10.29262\/ram.v658i2.783","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T22:44:02Z","timestamp":1631832242000},"page":"140-143","source":"Crossref","is-referenced-by-count":3,"title":["La prueba de activaci\u00f3n de bas\u00f3filos como ayuda para el diagn\u00f3stico y tratamiento de la anafilaxia asociada a un preparado de testosterona"],"prefix":"10.29262","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-6152","authenticated-orcid":false,"given":"Felipe","family":"Santos-Vicente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-0993","authenticated-orcid":false,"given":"Margarita","family":"Latasa-Eceizabarrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4751-1265","authenticated-orcid":false,"given":"Juan Luis","family":"Estrada-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7174-9658","authenticated-orcid":false,"given":"Bego\u00f1a","family":"P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-4573","authenticated-orcid":false,"given":"Mar\u00eda Luisa","family":"Sanz-Larruga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Schubert M, Minneman T, H\u00fcbler D, Rouskova D, Christoph A, Oettel M, et al. Intramuscular testosterone undecanoate: pharmacokinetic aspects of a novel testosterone formulation during long-term treatment of men with hypogonadism. J Clin Endocrinol Metab. 2004;89:5429-5434. DOI: 10.1210\/jc.2004-0897","DOI":"10.1210\/jc.2004-0897"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Hausmann OV, Gentinetta T, Bridts CH, Ebo DG. The basophil activation test in immediate -type drug allergy. Immunol Allergy Clin North Am. 2009;29:555-66. DOI: 10.1016\/j.iac.2009.04.011","DOI":"10.1016\/j.iac.2009.04.011"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, et al. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015;70:1393-1405. DOI: 10.1111\/all.12698","DOI":"10.1111\/all.12698"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Riffkin C, Huber R, Keysser CH. 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