{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:35:15Z","timestamp":1762079715225,"version":"3.37.3"},"reference-count":0,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>Antecedentes: Existe inflamaci\u00f3n bronquial subcl\u00ednica en pacientes con rinitis al\u00e9rgica. Son menos las evidencias de inflamaci\u00f3n de la v\u00eda a\u00e9rea inferior en rinitis no al\u00e9rgica.Objetivo: Investigar inflamaci\u00f3n de la v\u00eda a\u00e9rea inferior por la fracci\u00f3n exhalada de \u00f3xido n\u00edtrico (FeNO) en pacientes con rinitis al\u00e9rgica y rinitis no al\u00e9rgica sin asma y su asociaci\u00f3n con funci\u00f3n pulmonar, gravedad de la rinitis y biomarcadores de atopia.M\u00e9todos: Estudio transversal de pacientes entre seis y 18 a\u00f1os, con rinitis al\u00e9rgica o rinitis no al\u00e9rgica sin asma. Se realiz\u00f3 espirometr\u00eda, IgE s\u00e9rica, recuento de eosin\u00f3filos hem\u00e1ticos y FeNO. Se clasific\u00f3 la rinitis seg\u00fan gu\u00eda ARIA.Resultados: Se incluyeron 40 pacientes, 28 con rinitis al\u00e9rgica y 12 con rinitis no al\u00e9rgica. Los pacientes con rinitis al\u00e9rgica tuvieron niveles de FeNO m\u00e1s elevados (mediana 36.5\u00a0ppb, rango 5-114) que aquellos con rinitis no al\u00e9rgica (mediana 7\u00a0ppb, rango 5-24) (p\u00a0=\u00a00.0011). La FeNO elevada se asoci\u00f3 con anormalidad espirom\u00e9trica (RM = 7.14 [IC 95\u00a0% = 1.04-49.04], p\u00a0=\u00a00.049). En la rinitis al\u00e9rgica, existi\u00f3 correlaci\u00f3n entre FeNO y eosin\u00f3filos en sangre (r\u00a0=\u00a00.41, p\u00a0=\u00a00-33).Conclusiones: Los ni\u00f1os y adolescentes con rinitis al\u00e9rgica tuvieron FeNO m\u00e1s elevada que los pacientes con rinitis no al\u00e9rgica, que se correlacion\u00f3 con eosinofilia hem\u00e1tica y funci\u00f3n pulmonar alterada.<\/jats:p>","DOI":"10.29262\/ram.v66i3.583","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T02:20:16Z","timestamp":1570846816000},"page":"272-281","source":"Crossref","is-referenced-by-count":2,"title":["An\u00e1lisis comparativo de la fracci\u00f3n exhalada de \u00f3xido n\u00edtrico en ni\u00f1os y en adolescentes con rinitis al\u00e9rgica y no al\u00e9rgica"],"prefix":"10.29262","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9716-1825","authenticated-orcid":false,"given":"Ricardo","family":"Saranz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-0676","authenticated-orcid":false,"given":"Alejandro","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1235-2105","authenticated-orcid":false,"given":"Natalia Andrea","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-186X","authenticated-orcid":false,"given":"Graciela","family":"Alegre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2478-2532","authenticated-orcid":false,"given":"Laura Ver\u00f3nica","family":"Sasia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8759-0431","authenticated-orcid":false,"given":"Eugenia","family":"C\u00f3ncari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3073-3200","authenticated-orcid":false,"given":"Paula","family":"Robredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3549-2063","authenticated-orcid":false,"given":"Marina","family":"Ponzio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-3871","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2019,5,27]]},"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"http:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/583\/1048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/583\/1122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/583\/1071","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/583\/1048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T21:02:42Z","timestamp":1627678962000},"score":1,"resource":{"primary":{"URL":"http:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,27]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,10,7]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v66i3.583","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2019,5,27]]}}}