{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:19:24Z","timestamp":1757312364132,"version":"3.37.3"},"reference-count":0,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>Antecedentes: Trimetoprima-sulfametoxazol (TMP-SMZ) es el antimicrobiano de elecci\u00f3n y de uso prolongado en la prevenci\u00f3n y tratamiento de infecciones por g\u00e9rmenes oportunistas en los pacientes con s\u00edndrome de inmunodeficiencia adquirida (sida), en quienes la frecuencia de reacciones adversas a medicamentos es de 30 a 50\u00a0%.Objetivo: Determinar las reacciones adversas a TMP-SMZ y sus factores de riesgo en pacientes con sida.M\u00e9todos: Se incluyeron pacientes mayores de\u00a018 a\u00f1os con diagn\u00f3stico confirmado de infecci\u00f3n por VIH y que presentaron reacci\u00f3n adversa a f\u00e1rmacos, de enero de 2018 a mayo de 2019. Se revisaron 319 expedientes.Resultados: Se report\u00f3 13.16\u00a0% de reacciones adversas; de 42 pacientes con reacciones adversas a medicamentos, 23 fueron a TMP-SMZ (54.76\u00a0%). El rash represent\u00f3 56.5\u00a0% de las reacciones adversas, el angioedema 21.73\u00a0% y la urticaria 17.39\u00a0%. Los factores de riesgo fueron la comorbilidad infecciosa (RM = 2.6) y la cuenta de CD4\u00a0&lt;\u00a0100 (RM = 6.9), sin significaci\u00f3n estad\u00edstica; la dosis de TMP-SMZ fue un factor de riesgo (RM = 12.7), con p\u00a0=\u00a00.017.Conclusiones: El TMP-SMZ en los pacientes con sida ocasion\u00f3 54\u00a0% de las reacciones adversas a medicamentos y la dosis fue un factor de riesgo.<\/jats:p>","DOI":"10.29262\/ram.v67i2.670","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T22:58:42Z","timestamp":1599433122000},"page":"96-101","source":"Crossref","is-referenced-by-count":4,"title":["Frecuencia de reacciones adversas a sulfametoxazol con trimetoprima y factores de riesgo en pacientes con VIH"],"prefix":"10.29262","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8305-5530","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"Mart\u00ednez-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-138X","authenticated-orcid":false,"given":"Mar\u00eda del Roc\u00edo","family":"Hern\u00e1ndez-Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-8039","authenticated-orcid":false,"given":"Eleazar","family":"Mancilla-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2020,8,19]]},"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"http:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/670\/1215","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/670\/1255","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/670\/1239","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/670\/1215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T20:46:06Z","timestamp":1627418766000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,8,19]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v67i2.670","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2020,8,19]]}}}