{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:21:09Z","timestamp":1744258869565,"version":"3.40.4"},"reference-count":19,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Background: Inborn errors of immunity manifest with a greater susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, or malignancies. One of these is the mendelian susceptibility to mycobacterial disease. The most frequent etiology is the complete autosomal recessive deficiency of the \u03b21 subunit of the interleukin 12 receptor.\nCase report: A female patient who, by the age of six months, started with a nodular lesion in the right shoulder and ipsilateral axillary adenitis after the bacillus Calmette-Gu\u00e9rin vaccine was applied. Later, she developed a cutaneous fistula in the anterior thorax, the inframammary region, and chronic recidivant suppurative lymphadenitis. A disseminated infection caused by Mycobacterium bovis was diagnosed, therefore, individualized pharmacological treatment was required due to failure with the primary treatment. The patient was diagnosed with deficiency in the \u03b21 subunit of the interleukin 12 receptor at age six. During her last hospitalization, she presented fever, cough, and tachypnea, and SARS-CoV-2 was detected by quantitative polymerase chain reaction. The patient has had a favorable evolution.\nConclusion: In patients with disseminated infections caused by bacillus Calmette-Gu\u00e9rin vaccination or by environmental mycobacteria, there should be suspicion of an inborn error of immunity and the patient should be referred to a third level hospital for an early immunological assessment.<\/jats:p>","DOI":"10.29262\/ram.v67i4.798","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T12:59:30Z","timestamp":1613134770000},"page":"401-407","source":"Crossref","is-referenced-by-count":0,"title":["Infecci\u00f3n diseminada por vacuna con bacilo de Calmette-Gu\u00e9rin y coinfecci\u00f3n por SARS-CoV-2 en paciente con deficiencia de la subunidad \u03b21 del receptor de IL-12","Disseminated infection caused by the bacillus Calmette-Gu\u00e9rin vaccine and SARS-CoV-2 coinfection in a patient with IL-12 receptor \u03b21 subunit deficiency"],"prefix":"10.29262","volume":"67","author":[{"given":"Jes\u00fas Gerardo","family":"Allen-Manzur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Elva","family":"Espinosa-Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacinta","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizbeth","family":"Blancas-Galicia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Mendieta-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Tangye SG, Al-Herz W, Bousfiha A, Chatila T, Etzioni A, Franco JL, et al. 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Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Gu\u00e9rin infection. N Engl J Med. 1996;335(26):1956-1961. DOI: 10.1056\/NEJM199612263352604","DOI":"10.1056\/NEJM199612263352604"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Newport MJ, Huxley CM, Huston S, Hawrylowicz CM, Oostra BA, Levin M, et al. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med. 1996;335(26):1941-1949. DOI: 10.1056\/NEJM199612263352602","DOI":"10.1056\/NEJM199612263352602"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Bustamante J. Mendelian susceptibility to mycobacterial disease: recent discoveries. Hum Genet. 2020;139(6-7):993-1000. DOI: 10.1007\/s00439-020-02120-y","DOI":"10.1007\/s00439-020-02120-y"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Kerner G, Rosain J, Gu\u00e9rin A, Al-Khabaz A, Oleaga-Quintas C, Rapaport F, et al. 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