{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:21:09Z","timestamp":1744258869561,"version":"3.40.4"},"reference-count":10,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Background: In Mexico, adult-onset Still\u2019s disease (AOSD) is one of the causes of fever of unknown origin (FUO). The aim of this study is to describe a series of AOSD cases from a FUO cohort in order to know the clinical and biochemical characteristics of the cases, as well as to describe the neutrophil-lymphocyte index (NLI), which is a clinical marker of inflammation in autoimmune diseases.\nCase report: An observational study of 24 cases with AOSD; 72 % of them were women, the median age was 43 years (IQR 37.7-59.7), and the most frequent manifestations were classic rash (84 %) and arthralgia (100 %). All of them had tested negative for rheumatoid factor, antinuclear antibodies, and hyperferritinemia; 83 % had NLI &gt; 3.08. The most used treatment was the combination of methotrexate with corticosteroids; seven patients required biological therapy, and one of them presented a hypersensitivity reaction.\nConclusion: When there\u2019s FUO, the existence of AOSD should be suspected; also in the presence of rash, arthralgia, hyperferritinemia, and NLI &gt; 3.08.<\/jats:p>","DOI":"10.29262\/ram.v67i4.811","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T12:59:15Z","timestamp":1613134755000},"page":"413-420","source":"Crossref","is-referenced-by-count":0,"title":["Enfermedad de Still del adulto y el \u00edndice neutr\u00f3filo\/linfocito en poblaci\u00f3n mexicana. Reporte de serie de casos","Adult-onset Still\u2019s disease and the neutrophil-lymphocyte index in the Mexican population. A case series report"],"prefix":"10.29262","volume":"67","author":[{"given":"Coraz\u00f3n de Jes\u00fas","family":"Barrientos-Flores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura E.","family":"Noyola-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Albarr\u00e1n-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Victoria","family":"Torres-Araujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yisela","family":"Cano-Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Alberti-Minutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Anda-Garay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Wang MY, Jia JC, Yang CD, Hu, QY. Pathogenesis, disease course, and prognosis of adult-onset Still's disease: an update and review. Chin Med J. 2019;132(23):2856-2864. DOI: 10.1097\/CM9.0000000000000538","DOI":"10.1097\/CM9.0000000000000538"},{"key":"ref1","unstructured":"Fautrel B, Le Mo\u00ebl G, Saint-Marcoux B, Taupin P, Vignes S, Rozenberg S, et al. Diagnostic value of ferritin and glycosylated ferritin in adult-onset Still's disease. J Rheumatol. 2001;28(2):322-329. Disponible en: https:\/\/www.jrheum.org\/content\/jrheum\/28\/2\/322.full.pdf"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Crisp\u00edn JC, Mart\u00ednez-Ba\u00f1os D, Alcocer-Varela J. Adult-onset Still disease as the cause of fever of unknown origin. Medicine (Baltimore). 2005;84(6):331-337. DOI: 10.1097\/01.md.0000188009.47085.76","DOI":"10.1097\/01.md.0000188009.47085.76"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Seo JY, Suh CH, Jung JY, Kim AR, Yang JW, Kim HA. The neutrophil-to-lymphocyte ratio could be a good diagnostic marker and predictor of relapse in patients with adult-onset Still's disease: A STROBE-compliant retrospective observational analysis. Medicine, 2017;96(29):e7546. doi: 10.1097\/MD.0000000000007546","DOI":"10.1097\/MD.0000000000007546"},{"key":"ref4","unstructured":"Casarrubias-Ram\u00edrez M, Alfaro-Mej\u00eda JA, de Santiago-Lea\u00f1os J, Mendoza-\u00c1lvarez SA, Pineda-Galindo LF, Vera-Lastra OL. Fiebre de origen oscuro, comparaci\u00f3n de dos series con 26 a\u00f1os de diferencia. Rev Med Inst Mex Seguro Soc. 2015;53(S1):6-17. Disponible en: https:\/\/www.redalyc.org\/articulo.oa?id=457744941002"},{"key":"ref5","unstructured":"Kim YJ, Koo BS, Kim YG, Lee CK, Yoo B. Clinical features and prognosis in 82 patients with adult-onset Still's disease. Clin Exp Rheumatol. 2014;32(1):28-33."},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Wang Y, Hunt K, Nazareth I, et al Do men consult less than women? An analysis of routinely collected UK general practice data BMJ Open. 2013;3:e003320. DOI: 10.1136\/bmjopen-2013-003320","DOI":"10.1136\/bmjopen-2013-003320"},{"key":"ref7","unstructured":"Hu QY, Zeng T, Sun CY, Luo CN, Liu S, Ding TT, et al. Clinical features and current treatments of adult-onset Still's disease: a multicentre survey of 517 patients in China. Clin Exp Rheumatol. 2019;37(6):52-57."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Efthimiou P, Paik PK, Bielory L. Diagnosis and management of adult-onset Still's disease. Ann Rheum Dis. 2006;65(5):564-572. DOI: 10.1136\/ard.2005.042143","DOI":"10.1136\/ard.2005.042143"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Park EH, Lee EY, Shin K, Kim HA. Tocilizumab-induced anaphylaxis in patients with adult-onset Still's disease and systemic juvenile idiopathic arthritis: a case- based review. Rheumatol Int. 2020;40(5):791-798. DOI: 10.1007\/s00296-019-04456-9","DOI":"10.1007\/s00296-019-04456-9"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/811\/2342","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/811\/1351","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/811\/2342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T16:15:38Z","timestamp":1744215338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,12]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,1,9]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v67i4.811","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2021,2,12]]}}}