{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:50:33Z","timestamp":1747212633323,"version":"3.40.5"},"reference-count":10,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"1","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>Antecedentes: La neumonitis por hipersensibilidad agrupa varias enfermedades inflamatorias pulmonares que afectan preferentemente el tejido alveolar y perialveolar. En ni\u00f1os se trata de una enfermedad muy rara, con diagn\u00f3stico complicado debido a que la exposici\u00f3n antig\u00e9nica suele pasar desapercibida.\nCaso cl\u00ednico: Ni\u00f1a de 12 a\u00f1os que presentaba tos seca, disnea, sibilancias y taquipnea con mejor\u00eda parcial al tratamiento con broncodilatadores y corticoides inhalados. En la espirometr\u00eda present\u00f3 un patr\u00f3n restrictivo y una capacidad de difusi\u00f3n pulmonar reducida; en la tomograf\u00eda computarizada se observaron opacidades centrolobulillares en vidrio esmerilado y del lavado broncoalveolar se obtuvo un cociente de linfocitosis CD4\/CD8 de 2.46. Se obtuvo IgG positiva a plumas de aves.\nConclusiones: El manejo de la neumonitis por hipersensibilidad se basa en evitar la exposici\u00f3n al agente causante, lo que determina el pron\u00f3stico; de ah\u00ed que resulta de vital importancia realizar una historia cl\u00ednica exhaustiva. Pueden indicarse corticosteroides en funci\u00f3n de la respuesta cl\u00ednica, la funci\u00f3n pulmonar y la mejor\u00eda radiol\u00f3gica.<\/jats:p>","DOI":"10.29262\/ram.v68i1.844","type":"journal-article","created":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T01:15:01Z","timestamp":1624238101000},"page":"84-88","source":"Crossref","is-referenced-by-count":0,"title":["Ni\u00f1a con neumonitis por hipersensibilidad. 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Children (Basel). 2018;5(11):149. DOI: 10.3390\/children5110149","DOI":"10.3390\/children5110149"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Griese M, Haug M, Hartl D, Teusch V, Gl\u00f6ckner-Pagel J, Brasch F, et al. Hypersensitivity pneumonitis: lessons for diagnosis and treatment of a rare entity in children. Orphanet J Rare Dis. 2013;8:121. DOI: 10.1186\/1750-1172-8-121","DOI":"10.1186\/1750-1172-8-121"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Ratjen F, Costabel U, Griese M, Paul K. Bronchoalveolar lavage fluid findings in children with hypersensitivity pneumonitis. Eur Respir J. 2003;21(1):144-148. DOI: 10.1183\/09031936.03.00035703a","DOI":"10.1183\/09031936.03.00035703a"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Fern\u00e1ndez-P\u00e9rez ER, Swigris JJ, Forss\u00e9n AV, Tourin O, Solomon JJ, Huie TJ, et al. Identifying an inciting antigen is associated with improved survival in patients with chronic hypersensitivity pneumonitis. Chest. 2013;144(5):1644-1651. DOI: 10.1378\/chest.12-2685","DOI":"10.1378\/chest.12-2685"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Ryerson CJ, Vittinghoff E, Ley B, Lee JS, Mooney JJ, Jones KD, et al. Predicting survival across chronic interstitial lung disease: the ILD-GAP model. Chest. 2014;145(4):723-728. DOI: 10.1378\/chest.13-1474","DOI":"10.1378\/chest.13-1474"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Sisman Y, Buchvald F, Blyme AK, Mortensen J, Nielsen KG. Pulmonary function and fitness years after treatment for hypersensitivity pneumonitis during childhood. Pediatr Pulmonol. 2016;51(8):830-837. 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