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La ausencia de ERO producidos por la NADPH oxidasa en los neutr\u00f3filos y en los macr\u00f3fagos produce mayor susceptibilidad a infecciones bacterianas y f\u00fangicas, adem\u00e1s de manifestaciones inflamatorias por una respuesta inflamatoria desregulada, lo que sugiere que la capacidad para regular adecuadamente la se\u00f1alizaci\u00f3n inflamatoria depende de las ERO derivadas de la NADPH oxidasa. Los pacientes con EGC ligada al cromosoma X tienen un curso de enfermedad m\u00e1s grave con infecciones invasivas recurrentes, a diferencia de los pacientes con EGC no cl\u00e1sica, quienes no presentan infecciones bacterianas o f\u00fangicas invasivas, pero con manifestaciones inflamatorias m\u00e1s prominentes. Las manifestaciones gastrointestinales m\u00e1s frecuentes son estomatitis, gingivitis, diarrea cr\u00f3nica, abscesos hep\u00e1ticos, similares a las de la enfermedad inflamatoria intestinal (EII) y granulomas, que pueden provocar obstrucci\u00f3n o estenosis en es\u00f3fago, est\u00f3mago o intestino. Se ha observado que la deficiencia de p40phox y EROS (EGC no cl\u00e1sica) se asocia a mayor susceptibilidad a colitis y al desarrollo de inflamaci\u00f3n severa, por lo que se plantea que estas prote\u00ednas participan en la resoluci\u00f3n de la inflamaci\u00f3n. En general, los hallazgos inflamatorios en la EGC, incluyendo los gastrointestinales, han sido poco descritos. En las cohortes internacionales se reportan manifestaciones similares a EII hasta en 58\u00a0% de los pacientes con EGC; en cambio, en la \u00fanica cohorte mexicana se describe su hallazgo solo en cuatro de 93 pacientes (4.3\u00a0%). En esta revisi\u00f3n resumimos los hallazgos cl\u00ednicos gastrointestinales de la EGC, incluidas las manifestaciones infecciosas e inflamatorias, con \u00e9nfasis en las \u00faltimas.<\/jats:p>","DOI":"10.29262\/ram.v68i3.860","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T19:21:36Z","timestamp":1634066496000},"page":"198-205","source":"Crossref","is-referenced-by-count":5,"title":["Manifestaciones gastrointestinales inflamatorias e infecciosas de la enfermedad  granulomatosa cr\u00f3nica"],"prefix":"10.29262","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2897-0255","authenticated-orcid":false,"given":"Madelein","family":"Toledo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-302X","authenticated-orcid":false,"given":"Alejandro","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-5721","authenticated-orcid":false,"given":"Selma","family":"Scheffler-Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-9419","authenticated-orcid":false,"given":"Ximena","family":"Le\u00f3n-Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-5291","authenticated-orcid":false,"given":"Hiromi","family":"Onuma-Zamayoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-3151","authenticated-orcid":false,"given":"Sara","family":"Espinosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-3923","authenticated-orcid":false,"given":"Marco Antonio","family":"Yamazaki-Nakashimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-8864","authenticated-orcid":false,"given":"Lizbeth","family":"Blancas Galicia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Arnold DE, Heimall JR. A review of chronic granulomatous disease. Adv Ther. 2017;34(12):2543-2557. DOI: 10.1007\/s12325-017-0636-2","DOI":"10.1007\/s12325-017-0636-2"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Gennery A. Recent advances in understanding and treating chronic granulomatous disease. F1000Res. 2017;6:1427. DOI: 10.12688\/f1000research.11789.1","DOI":"10.12688\/f1000research.11789.1"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Song E, Jaishankar GB, Saleh H, Jithpratuck W, Sahni R, Krishnaswamy G. Chronic granulomatous disease: a review of the infectious and inflammatory complications. Clin Mol Allergy. 2011;9(1):10. DOI: 10.1186\/1476-7961-9-10","DOI":"10.1186\/1476-7961-9-10"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Dinauer MC. Inflammatory consequences of inherited disorders affecting neutrophil function. Blood. 2019;133(20):2130-2139. DOI: 10.1182\/blood-2018-11-844563","DOI":"10.1182\/blood-2018-11-844563"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Dahlgren C, Karlsson A, Bylund J. intracellular neutrophil oxidants: from laboratory curiosity to clinical reality. J Immunol. 2019;202(11):3127-3134. DOI: 10.4049\/jimmunol.1900235","DOI":"10.4049\/jimmunol.1900235"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Conway KL, Goel G, Sokol H, Manocha M, Mizoguchi E, Terhorst C, et al. p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation. J Immunol. 2012;189(7):3631-3640. DOI: 10.4049\/jimmunol.1103746","DOI":"10.4049\/jimmunol.1103746"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Felmy B, Songhet P, Slack EM, Muller AJ, Kremer M, Van Maele L, et al. NADPH oxidase deficient mice develop colitis and bacteremia upon infection with normally avirulent, TTSS-1- and TTSS-2-deficient Salmonella Typhimurium. PLoS One. 2013;8(10):e77204. DOI: 10.1371\/journal.pone.0077204","DOI":"10.1371\/journal.pone.0077204"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Aviello G, Singh AK, O'Neill S, Conroy E, Gallagher W, D'Agostino G, et al. Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects. Mucosal Immunology. 2019;12(6):1316-26. Disponible en: https:\/\/www.nature.com\/articles\/s41385-019-0205-x","DOI":"10.1038\/s41385-019-0205-x"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"van de Geer A, Nieto-Patlan A, Kuhns DB, Tool AT, Arias AA, Bouaziz M, et al. Inherited p40phox deficiency differs from classic chronic granulomatous disease. J Clin Invest. 2018;128(9):3957-3975. DOI: 10.1172\/JCI97116","DOI":"10.1172\/JCI97116"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Goldblatt D. Recent advances in chronic granulomatous disease. J Infect. 2014;69(Suppl 1):S32-S35. DOI: 10.1016\/j.jinf.2014.07.013","DOI":"10.1016\/j.jinf.2014.07.013"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Leiding JW, Holland SM. Chronic granulomatous disease. En: GeneReviews [Internet]. EE. UU.: University of Washington; c2020.","DOI":"10.1016\/B978-0-12-816768-7.00037-5"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Gao LW, Yin QQ, Tong YJ, Gui JG, Liu XY, Feng XL, et al. Clinical and genetic characteristics of Chinese pediatric patients with chronic granulomatous disease. Pediatr Allergy Immunol. 2019;30(3):378-386. DOI: 10.1111\/pai.13033","DOI":"10.1111\/pai.13033"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Raptaki M, Varela I, Spanou K, Tzanoudaki M, Tantou S, Liatsis M, et al. Chronic granulomatous disease: a 25-year patient registry based on a multistep diagnostic procedure, from the referral center for primary immunodeficiencies in Greece. J Clin Immunol. 2013;33(8):1302-1309. DOI: 10.1007\/s10875-013-9940-z","DOI":"10.1007\/s10875-013-9940-z"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Fattahi F, Badalzadeh M, Sedighipour L, Movahedi M, Fazlollahi MR, Mansouri SD, et al. Inheritance pattern and clinical aspects of 93 Iranian patients with chronic granulomatous disease. J Clin Immunol. 2011;31(5):792-801. DOI: 10.1007\/s10875-011-9567-x","DOI":"10.1007\/s10875-011-9567-x"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Kutukculer N, Aykut A, Karaca NE, Durmaz A, Aksu G, Genel F, et al. Chronic granulamatous disease: two decades of experience from a paediatric immunology unit in a country with high rate of consangineous marriages. Scand J Immunol. 2019;89(2):e12737. DOI: 10.1111\/sji.12737","DOI":"10.1111\/sji.12737"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Wolach B, Gavrieli R, de Boer M, Gottesman G, Ben-Ari J, Rottem M, et al. 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DOI: 10.1155\/2017\/8745254","DOI":"10.1155\/2017\/8745254"},{"issue":"3","key":"ref18","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s10875-020-00750-5","article-title":"Genetic, immunological, and clinical features of the first mexican cohort of patients with chronic granulomatous disease","volume":"40","author":"Blancas-Galicia","year":"2020","unstructured":"Blancas-Galicia L, Santos-Chavez E, Deswarte C, Mignac Q, Medina-Vera I, Leon-Lara X, et al. Genetic, immunological, and clinical features of the first mexican cohort of patients with chronic granulomatous disease. J Clin Immunol. 2020;40(3):475-493.","journal-title":"J Clin Immunol"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Roos D. Chronic granulomatous disease. Br Med Bull. 2016;118(1):50-63. DOI: 10.1093\/bmb\/ldw009","DOI":"10.1093\/bmb\/ldw009"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Venegas-Montoya E, Sorcia-Ram\u00edrez G, Scheffler-Mendoza S, Blancas-Galicia L, Bustamante J, Espinosa-Rosales F, et al. Use of corticosteroids as an alternative to surgical treatment for liver abscesses in chronic granulomatous disease. Pediatr Blood Cancer. 2016;63(12):2254-2255. DOI: 10.1002\/pbc.26140","DOI":"10.1002\/pbc.26140"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Straughan DM, McLoughlin KC, Mullinax JE, Marciano BE, Freeman AF, Anderson VL, et al. The changing paradigm of management of liver abscesses in chronic granulomatous disease. Clin Infect Dis. 2018;66(9):1427-1434. DOI: 10.1093\/cid\/cix1012","DOI":"10.1093\/cid\/cix1012"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Dunogu\u00e9 B, Pilmis B, Mahlaoui N, Elie C, Coignard-Biehler H, Amazzough K, et al. 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The clinical features and genetic mutations of chronic granulomatous disease: results from a reference centre at middle Anatolia. Genet Couns. 2013;24(3):327-335."},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Feld JJ, Hussain N, Wright EC, Kleiner DE, Hoofnagle JH, Ahlawat S, et al. Hepatic involvement and portal hypertension predict mortality in chronic granulomatous disease. Gastroenterology. 2008;134(7):1917-1926. DOI: 10.1053\/j.gastro.2008.02.081","DOI":"10.1053\/j.gastro.2008.02.081"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Winkelstein JA, Marino MC, Johnston RB, Boyle J, Curnutte J, Gallin JI, et al. Chronic granulomatous disease. Report on a national registry of 368 patients. Medicine (Baltimore). 2000;79(3):155-169. DOI: 10.1097\/00005792-200005000-00003","DOI":"10.1097\/00005792-200005000-00003"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Tajik S, Badalzadeh M, Fazlollahi MR, Houshmand M, Bazargan N, Movahedi M, et al. Genetic and molecular findings of 38 Iranian patients with chronic granulomatous disease caused by p47-phox defect. Scand J Immunol. 2019;90(1):e12767. DOI: 10.1111\/sji.12767","DOI":"10.1111\/sji.12767"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Jakobsen MA, Katzenstein TL, Valerius NH, Roos D, Fisker N, Mogensen TH, et al. Genetical analysis of all Danish patients diagnosed with chronic granulomatous disease. Scand J Immunol. 2012;76(5):505-511. DOI: 10.1007\/s00281-008-0128-1","DOI":"10.1007\/s00281-008-0128-1"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Giannopoulou C, Krause KH, Muller F. The NADPH oxidase NOX2 plays a role in periodontal pathologies. Semin Immunopathol. 2008;30(3):273-278. DOI: 10.1007\/s00281-008-0128-1","DOI":"10.1007\/s00281-008-0128-1"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Pasic S, Minic A, Minic P, Veljkovic D, Lilic D, Slavkovic B, et al. Long-term follow-up and prognosis of chronic granulomatous disease in Yugoslavia: is there a role for early bone marrow transplantation? J Clin Immunol. 2003;23(1):55-61. DOI: 10.1023\/a:1021952315651","DOI":"10.1023\/A:1021952315651"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Rawat A, Vignesh P, Sharma A, Shandilya JK, Sharma M, Suri D, et al. Infection profile in chronic granulomatous disease: a 23-year experience from a tertiary care center in North India. J Clin Immunol. 2017;37(3):319-328. DOI: 10.1007\/s10875-017-0382-x","DOI":"10.1007\/s10875-017-0382-x"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Robles-Marhuenda A, \u00c1lvarez-Troncoso J, Rodr\u00edguez-Pena R, Busca-Arenzana C, L\u00f3pez-Granados E, Arnalich-Fern\u00e1ndez F. Chronic granulomatous disease: Single-center Spanish experience. Clin Immunol. 2019;211:108323. DOI: 10.1016\/j.clim.2019.108323","DOI":"10.1016\/j.clim.2019.108323"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"van den Berg JM, van Koppen E, Ahlin A, Belohradsky BH, Bernatowska E, Corbeel L, et al. Chronic granulomatous disease: the European experience. PLoS One. 2009;4(4):e5234. DOI: 10.1371\/journal.pone.0005234","DOI":"10.1371\/journal.pone.0005234"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Martire B, Rondelli R, Soresina A, Pignata C, Broccoletti T, Finocchi A, et al. Clinical features, long-term follow-up and outcome of a large cohort of patients with chronic granulomatous disease: an Italian multicenter study. Clin Immunol. 2008;126(2):155-164. DOI: 10.1016\/j.clim.2007.09.008","DOI":"10.1016\/j.clim.2007.09.008"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Agudelo-Florez P, Prando-Andrade CC, Lopez JA, Costa-Carvalho BT, Quezada A, Espinosa FJ, et al. Chronic granulomatous disease in Latin American patients: clinical spectrum and molecular genetics. Pediatr Blood Cancer. 2006;46(2):243-252. DOI: 10.1002\/pbc.20455","DOI":"10.1002\/pbc.20455"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Khangura SK, Kamal N, Ho N, Quezado M, Zhao X, Marciano B, et al. Gastrointestinal features of chronic granulomatous disease found during endoscopy. Clin Gastroenterol Hepatol. 2016;14(3):395-402. DOI: 10.1016\/j.cgh.2015.10.030","DOI":"10.1016\/j.cgh.2015.10.030"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Jones LB, McGrogan P, Flood TJ, Gennery AR, Morton L, Thrasher A, et al. Special article: chronic granulomatous disease in the United Kingdom and Ireland: a comprehensive national patient-based registry. Clin Exp Immunol. 2008;152(2):211-218. DOI: 10.1111\/j.1365-2249.2008.03644.x","DOI":"10.1111\/j.1365-2249.2008.03644.x"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Liese JG, Jendrossek V, Jansson A, Petropoulou T, Kloos S, Gahr M, et al. Chronic granulomatous disease in adults. Lancet. 1996;347(8996):220-223. DOI: 10.1016\/s0140-6736(96)90403-1","DOI":"10.1016\/S0140-6736(96)90403-1"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Teimourian S, Rezvani Z, Badalzadeh M, Kannengiesser C, Mansouri D, Movahedi M, et al. Molecular diagnosis of X-linked chronic granulomatous disease in Iran. Int J Hematol. 2008;87(4):398-404. DOI: 10.1007\/s12185-008-0060-0","DOI":"10.1007\/s12185-008-0060-0"},{"issue":"10","key":"ref41","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/01.mph.0000139455.29962.be","article-title":"X-linked chronic granulomatous disease: first report of mutations in patients of Argentina","volume":"26","author":"Barese","year":"2004","unstructured":"Barese C, Copelli S, Zandomeni R, Oleastro M, Zelazko M, Rivas EM. X-linked chronic granulomatous disease: first report of mutations in patients of Argentina. J Pediatr Hematol Oncol. 2004;26(10):656-660.","journal-title":"J Pediatr Hematol Oncol"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"de Oliveira-Junior EB, Zurro NB, Prando C, Cabral-Marques O, Pereira PV, Schimke LF, et al. Clinical and genotypic spectrum of chronic granulomatous disease in 71 Latin American patients: first report from the LASID registry. Pediatr Blood Cancer. 2015;62(12):2101-2107. DOI: 10.1002\/pbc.25674","DOI":"10.1002\/pbc.25674"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Wang S, Wang T, Xiang Q, Xiao M, Cao Y, Xu H, et al. Clinical and molecular features of chronic granulomatous disease in mainland China and a XL-CGD female infant patient after prenatal diagnosis. J Clin Immunol. 2019;39(8):762-775. DOI: 10.1007\/s10875-019-00680-x","DOI":"10.1007\/s10875-019-00680-x"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Henrickson SE, Jongco AM, Thomsen KF, Garabedian EK, Thomsen IP. Noninfectious manifestations and complications of chronic granulomatous disease. J Pediatric Infect Dis Soc. 2018;7(Suppl 1):S18-S24. DOI: 10.1093\/jpids\/piy014","DOI":"10.1093\/jpids\/piy014"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Arnadottir GA, Norddahl GL, Gudmundsdottir S, Agustsdottir AB, Sigurdsson S, Jensson BO, et al. A homozygous loss-of-function mutation leading to CYBC1 deficiency causes chronic granulomatous disease. Nat Commun. 2018;9(1):4447. DOI: 10.1038\/s41467-018-06964-x","DOI":"10.1038\/s41467-018-06964-x"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Kobayashi S, Murayama S, Takanashi S, Takahashi K, Miyatsuka S, Fujita T, et al. Clinical features and prognoses of 23 patients with chronic granulomatous disease followed for 21 years by a single hospital in Japan. Eur J Pediatr. 2008;167(12):1389-1394. DOI: 10.1007\/s00431-008-0680-7","DOI":"10.1007\/s00431-008-0680-7"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Angelino G, de Angelis P, Faraci S, Rea F, Romeo EF, Torroni F, et al. Inflammatory bowel disease in chronic granulomatous disease: An emerging problem over a twenty years' experience. Pediatr Allergy Immunol. 2017;28(8):801-809. DOI: 10.1111\/pai.12814","DOI":"10.1111\/pai.12814"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Marciano BE, Rosenzweig SD, Kleiner DE, Anderson VL, Darnell DN, Anaya-O'Brien S, et al. Gastrointestinal involvement in chronic granulomatous disease. Pediatrics. 2004;114(2):462-468. DOI: 10.1542\/peds.114.2.462","DOI":"10.1542\/peds.114.2.462"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Wright M, Chandrakasan S, Okou DT, Yin H, Jurickova I, Denson LA, et al. Early onset granulomatous colitis associated with a mutation in NCF4 resolved with hematopoietic stem cell transplantation. J Pediatr. 2019;210:220-225. DOI: 10.1016\/j.jpeds.2019.03.042","DOI":"10.1016\/j.jpeds.2019.03.042"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Sokol H, Suarez F, Meatchi T, Malamut G, Pocidalo MA, Blanche S, et al. Thalidomide as a treatment for refractory CGD colitis. Am J Gastroenterol. 2009;104(4):1069. 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DOI: 10.1007\/s00431-008-0721-2","DOI":"10.1007\/s00431-008-0721-2"},{"issue":"6","key":"ref53","doi-asserted-by":"publisher","first-page":"1748","DOI":"10.1016\/j.jaip.2017.07.035","article-title":"Treatment of chronic granulomatous disease-associated fistulising colitis with vedolizumab","volume":"5","author":"Campbell","year":"2017","unstructured":"Campbell N, Chapdelaine H. Treatment of chronic granulomatous disease-associated fistulising colitis with vedolizumab. J Allergy Clin Immunol Pract. 2017;5(6):1748-1749.","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Falcone EL, Holland SM. Gastrointestinal complications in chronic granulomatous disease. Methods Mol Biol. 2019;1982:573-586. DOI: 10.1007\/978-1-4939-9424-3_34","DOI":"10.1007\/978-1-4939-9424-3_34"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Bortoletto P, Lyman K, Camacho A, Fricchione M, Khanolkar A, Katz BZ. Chronic granulomatous disease: a large, single-center US experience. Pediatr Infect Dis J. 2015;34(10):1110-1114. 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