{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:50:33Z","timestamp":1747212633793,"version":"3.40.5"},"reference-count":10,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>Introducci\u00f3n: El diagn\u00f3stico y tratamiento del angioedema hereditario (AEH) son necesarios para mejorar la calidad de vida e incluso la supervivencia de pacientes.\nReporte de caso: Mujer de 52 a\u00f1os con angioedema desde hace 30 a\u00f1os, que afecta cara, lengua y manos, asim\u00e9trico, sin prurito ni urticaria, sin respuesta a antihistam\u00ednicos ni corticoides, resoluci\u00f3n espont\u00e1nea entre las 48 a 72 horas, historia familiar de angioedema. Examen f\u00edsico normal entre las exacerbaciones. Se descartaron enfermedades autoinmunes, linfoproliferativas. Los valores de C1q, C4, C1-INH fueron normales. Diagn\u00f3stico de AEH tipo C1-INH normal subtipo unknown. Tratamiento iniciado con andr\u00f3genos: resoluci\u00f3n total de las crisis a los dos meses. Seguimiento ambulatorio durante cuatro a\u00f1os, sin crisis de angioedema, asociado con un cambio total en la calidad de vida.\nConclusiones: La paciente fue diagnosticada de AEH solo despu\u00e9s de 30 a\u00f1os de manifestaciones cl\u00ednicas, despu\u00e9s de descartar angioedema adquirido.<\/jats:p>","DOI":"10.29262\/ram.v68i3.874","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T23:21:29Z","timestamp":1634080889000},"page":"206-208","source":"Crossref","is-referenced-by-count":0,"title":["Diagn\u00f3stico de angioedema hereditario despu\u00e9s de treinta a\u00f1os de manifestaciones cl\u00ednicas"],"prefix":"10.29262","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-0444","authenticated-orcid":false,"given":"Luiz Fernando","family":"Bacarini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6390-5091","authenticated-orcid":false,"given":"Ana Luisa","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8550","authenticated-orcid":false,"given":"Mariana","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5944-3138","authenticated-orcid":false,"given":"Tain\u00e1","family":"Mosca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-1822","authenticated-orcid":false,"given":"Wilma Carvalho","family":"Neves-Forte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Holgu\u00edn-G\u00f3mez LM, V\u00e1squez-Ochoa LA, Cardona R. Angioedema. Rev Alerg Mex. 2016;63(4):373-384. Disponible en: https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/220\/384","DOI":"10.29262\/ram.v63i4.220"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Araujo A, Pinto J, Almeida P, Pinheiro B, Morete A. Angioedema heredit\u00e1rio: a import\u00e2ncia da suspeita cl\u00ednica e do tratamento adequado. Medicina Interna (Lisboa). 2018;25(1):40-42. DOI:10.24950\/rspmi\/CC\/146\/1\/2018","DOI":"10.24950\/rspmi\/CC\/146\/1\/2018"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Giavina-Bianchi P, Arruda LK, Aun MV, Campos RA, Chong-Neto HJ, Constantino-Silva RN, et al. Diretrizes brasileiras para o diagn\u00f3stico e tratamento do angioedema heredit\u00e1rio. Arq Asma Alerg Imunol. 2017;1(1):23-48. DOI: 10.5935\/2526-5393.20170005","DOI":"10.5935\/2526-5393.20170005"},{"key":"ref3","unstructured":"Neves-Forte WC. Imunologia do b\u00e1sico ao aplicado. Brasil: Editora Atheneu; 2015."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Larrauri B, Hester CG, Jiang H, Malbran A, Bork K, Kaplan A, et al. Sgp120 and the contact system in hereditary angioedema: a diagnostic tool in HAE with normal C1 inhibitor. Mol Immunol. 2020;119:27-34. DOI: 10.1016\/j.molimm.2020.01.003","DOI":"10.1016\/j.molimm.2020.01.003"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Henao MP, Kraschnewski JL, Kelbel T, Craig TJ. Diagnosis and screening of patients with hereditary angioedema in primary care. The Clin Risk Manag. 2016;12:701-711. DOI: 10.2147\/TCRM.S86293","DOI":"10.2147\/TCRM.S86293"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Bork K, Barnstedt SE, Koch P, Traupe H. Hereditary angioedema with normal C1-inhibitor activity in women. Lancet. 2000;356(9225):213-217. DOI: 10.1016\/S0140-6736(00)02483-1","DOI":"10.1016\/S0140-6736(00)02483-1"},{"key":"ref7","unstructured":"Guimar\u00e3es PV, Bastos RM, Valle SOR, Neves ARR, Levy SAP, Reis FAA, et al. Angioedema heredit\u00e1rio com inibidor de C1 normal-relato de caso e revis\u00e3o de literatura. Rev Bras Alerg Imunopatol. 2007;30(6):247-249."},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Maurer M, Magerl M, Ansotegui I, Bowen T, Potter P, Zuraw B, et al. The international WAO\/EAACI guideline for the management of hereditary angioedema - The 2017 revision and update. Allergy. 2018;73(8):1575-1596. DOI: 10.1111\/all.13384","DOI":"10.1111\/all.13384"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Busse PJ, Christiansen SC, Riedl MA, Banerji A, Bernstein J, Castaldo AJ, Craig T, et al. US HAEA medical advisory board 2020 guidelines for the management of hereditary angioedema. J Allergy Clin Immunol Pract. 2021;9(1):132-150. 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