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Actualmente, la eficacia de los f\u00e1rmacos utilizados contra COVID-19 es limitada y a pesar de que los programas de inmunizaci\u00f3n han iniciado, existe una desigualdad internacional en la distribuci\u00f3n de vacunas. En este sentido, la b\u00fasqueda de terapias coadyuvantes contin\u00faa siendo una alternativa para su investigaci\u00f3n. La suplementaci\u00f3n con vitamina A se ha asociado con la reducci\u00f3n de mortalidad por infecciones; este efecto podr\u00eda ser mediado por el \u00e1cido retinoico (AR), un metabolito activo de esta vitamina, que ejerce funciones inmunomoduladoras. De acuerdo con estudios precl\u00ednicos, el AR favorece la producci\u00f3n de inmunoglobulina A (IgA) secretora en el tracto respiratorio. Aunado a esto, la prote\u00edna de uni\u00f3n a retinol se ha correlacionado con la concentraci\u00f3n de IgA y anticuerpos neutralizantes en pacientes con influenza. Por lo tanto, la presente revisi\u00f3n tiene como objetivo abordar la participaci\u00f3n de la vitamina A en la producci\u00f3n de la inmunoglobulina A secretora en el epitelio del tracto respiratorio para resaltar su potencial funci\u00f3n protectora contra la infecci\u00f3n por SARS-CoV-2.<\/jats:p>","DOI":"10.29262\/ram.v68i3.977","type":"journal-article","created":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T20:54:27Z","timestamp":1634072067000},"page":"185-197","source":"Crossref","is-referenced-by-count":4,"title":["Participaci\u00f3n de la vitamina A en la producci\u00f3n de IgA secretora en el epitelio del tracto respiratorio para la potencial protecci\u00f3n de infecci\u00f3n por SARS-CoV-2"],"prefix":"10.29262","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-168X","authenticated-orcid":false,"given":"Francisco Javier","family":"Turrubiates-Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-1811","authenticated-orcid":false,"given":"Jorge","family":"Hern\u00e1ndez-Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6010-0837","authenticated-orcid":false,"given":"Edith","family":"Oreg\u00f3n-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0244-6298","authenticated-orcid":false,"given":"Guillermo","family":"Gonz\u00e1lez-Estevez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2272-9260","authenticated-orcid":false,"given":"Jos\u00e9 Francisco","family":"Mu\u00f1oz-Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Zhu N, Zhang D, Wang W, et al. 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