{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:50:36Z","timestamp":1747212636944,"version":"3.40.5"},"reference-count":44,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"1","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>La presentaci\u00f3n cl\u00ednica, curso de la enfermedad y resultado de la infecci\u00f3n por SARS-CoV-2 en pediatr\u00eda difieren de los observados en adultos. En una revisi\u00f3n de Hoang et al. se estim\u00f3 que la prevalencia de las manifestaciones dermatol\u00f3gicas fue de 0.25 % de un total de 2445 ni\u00f1os con COVID-19 confirmada. Seg\u00fan Parri, se document\u00f3 3\u00a0% en 100 ni\u00f1os. En la revisi\u00f3n sistem\u00e1tica de Shah et al. se analizaron 13 estudios que incluyeron 149 ni\u00f1os que cumplieron con los criterios de elegibilidad. La lesi\u00f3n maculopapular eritematosa acral fue la m\u00e1s com\u00fan, tambi\u00e9n el eritema multiforme, el exantema de la varicela y las presentaciones similares a enfermedad de Kawasaki. La duraci\u00f3n de las lesiones cut\u00e1neas fue de una a dos semanas en 43\u00a0%. La biopsia de piel de 18 casos revel\u00f3 infiltrado linfoc\u00edtico perivascular, infiltrado paracrino superficial y profundo y vasculitis linfoc\u00edtica. La RT-PCR fue positiva en 13.8\u00a0%. Los marcadores serol\u00f3gicos analizados de virus de herpes simple y parvovirus B19 fueron negativos, y fueron positivos para Mycoplasma pneumoniae en dos de 20 casos. El mecanismo fisiopatol\u00f3gico de las lesiones en piel secundarias a infecci\u00f3n por SARS-CoV-2 a\u00fan no se ha podido explicar; es probable que se trate de la combinaci\u00f3n de uno o m\u00e1s mecanismos complejos, da\u00f1os cut\u00e1neos directos inducidos por el virus, reacciones vascul\u00edticas o lesiones indirectas o secundarias como consecuencia de una reacci\u00f3n inflamatoria sistem\u00e1tica. Se revisaron las publicaciones de 2019 a 2021 en PubMed como fuente principal de b\u00fasqueda, para lo cual se utilizaron palabras clave.<\/jats:p>","DOI":"10.29262\/ram.v69i1.1000","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T02:56:52Z","timestamp":1656730612000},"page":"14-20","source":"Crossref","is-referenced-by-count":0,"title":["Piel y SARS-CoV-2 en pediatr\u00eda"],"prefix":"10.29262","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-6711","authenticated-orcid":false,"given":"Mar\u00eda Claudia","family":"Ortega-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"doi-asserted-by":"publisher","unstructured":"Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, et al. COVID-19 in 7780 pediatric patients: a systematic review. Lancet. 2020;24:100433. 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