{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T04:28:47Z","timestamp":1762057727646,"version":"build-2065373602"},"reference-count":110,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"1","license":[{"start":{"date-parts":[[2023,1,31]],"date-time":"2023-01-31T00:00:00Z","timestamp":1675123200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>La inmunodeficiencia combinada (IDC) por deficiencia de DOCK8 es un error innato de la inmunidad, caracterizado por alteraci\u00f3n en linfocitos T y B; el espectro de manifestaciones incluye alergia, autoinmunidad, inflamaci\u00f3n, predisposici\u00f3n a c\u00e1ncer e infecciones recurrentes. La deficiencia de DOCK8 se puede distinguir de otras IDC o dentro del espectro de s\u00edndromes de hiper-IgE porque presenta una profunda susceptibilidad a las infecciones virales de la piel, con c\u00e1nceres de piel asociados y alergias alimentarias graves. El locus subtelom\u00e9rico 9p24.3, donde se ubica DOCK8, incluye numerosos elementos repetitivos de secuencia que predisponen a la generaci\u00f3n de grandes deleciones de la l\u00ednea germinal, as\u00ed como a la reparaci\u00f3n del ADN som\u00e1tico, mediada por recombinaci\u00f3n. La producci\u00f3n residual de la prote\u00edna DOCK8 contribuye al fenotipo variable de la enfermedad. Las infecciones virales graves de la piel y la vasculopat\u00eda asociada a virus de la varicela Z\u00f3ster (VVZ) reflejan una funci\u00f3n importante de la prote\u00edna DOCK8, que normalmente se requiere para mantener la integridad de los linfocitos a medida que las c\u00e9lulas migran a trav\u00e9s de tejidos. La p\u00e9rdida de DOCK8 provoca deficiencias inmunitarias a trav\u00e9s de otros mecanismos, incluido un defecto de supervivencia celular. Existen alteraciones en la respuesta de las c\u00e9lulas dendr\u00edticas, lo que explica la susceptibilidad a infecci\u00f3n por virus, as\u00ed como en los linfocitos T reguladores que podr\u00edan ayudar a explicar la autoinmunidad en los pacientes. El trasplante de c\u00e9lulas hematopoy\u00e9ticas pluripotenciales es por el momento el \u00fanico tratamiento curativo, mejora el eccema, la alergia y la susceptibilidad a infecciones.<\/jats:p>","DOI":"10.29262\/ram.v69i1.1104","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T02:51:19Z","timestamp":1656730279000},"page":"31-47","source":"Crossref","is-referenced-by-count":2,"title":["Inmunodeficiencia combinada debida a deficiencia de DOCK8. Lo que sabemos hasta ahora"],"prefix":"10.29262","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2118-4489","authenticated-orcid":false,"given":"Eduardo","family":"Liquidano-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9001-6513","authenticated-orcid":false,"given":"Gibert","family":"Maza-Ramos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7609-3923","authenticated-orcid":false,"given":"Marco","family":"Yamazaki-Nakashimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-9916","authenticated-orcid":false,"given":"Tania","family":"Barrag\u00e1n-Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-4150","authenticated-orcid":false,"given":"Sa\u00fal Oswaldo","family":"Lugo-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6548-5721","authenticated-orcid":false,"given":"Selma C.","family":"Scheffler-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-3151","authenticated-orcid":false,"given":"Sara Elva","family":"Espinosa-Padilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-0466","authenticated-orcid":false,"given":"Mar\u00eda Edith","family":"Gonz\u00e1lez-Serrano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,1,31]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Su HC, Jing H, Angelus P, Freeman AF. Insights into immunity from clinical and basic science studies of DOCK8 immunodeficiency syndrome. Immunol Rev. 2019;287(1):9-19. DOI: 10.1111\/imr.12723","DOI":"10.1111\/imr.12723"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Zhang Q, Davis JC, Lamborn IT, Freeman AF, Jing H, Favreau AJ, et al. Combined Immunodeficiency associated with DOCK8 mutations. N England J Med. 2009;361(21):2046-2055. DOI: 10.1056\/NEJMoa0905506","DOI":"10.1056\/NEJMoa0905506"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Zhang Q, Davis J, Dove C, Su H. Genetic, clinical, and laboratory markers for DOCK8 immunodeficiency syndrome. Dis Markers. 2010;29(3-4):131-139. DOI: 10.3233\/DMA-2010-0737","DOI":"10.1155\/2010\/972591"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Nishikimi A, Kukimoto-Niino M, Yokoyama S, Fukui Y. Immune regulatory functions of DOCK family proteins in health and disease. Exp Cell Res. 2013;319(15):2343-2349. DOI: 10.1016\/j.yexcr.2013.07.024","DOI":"10.1016\/j.yexcr.2013.07.024"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Biggs CM, Keles S, Chatila TA. DOCK8 deficiency: Insights into pathophysiology, clinical features and management. Clin Immunol. 2017;181:75-82. DOI: 10.1016\/j.clim.2017.06.003","DOI":"10.1016\/j.clim.2017.06.003"},{"key":"ref5","unstructured":"LASID Registry [Internet]. Brasil: General statistic; 2022. Disponible en: https:\/\/lasidregistry.org\/view\/statistics\/general\/2022-02"},{"key":"ref6","unstructured":"The United States Immunodeficiency Network [Internet]. Registry-Reported Statistics; 2022. Disponible en: https:\/\/usidnet.org\/registry-data\/stats-registry-enrollment\/"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Haskologlu S, Kostel-Bal S, Islamoglu C, Aytekin C, Guner S, Sevinc S, et al. Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency. Pediatr Allergy Immunol. 2020;31(5):515-527. DOI: 10.1111\/pai.13236","DOI":"10.1111\/pai.13236"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Mandola AB, Levy J, Nahum A, Hadad N, Levy R, Rylova A, et al. Neutrophil functions in immunodeficiency due to DOCK8 deficiency. Immunological Investigations. 2019;48(4):431-439. DOI: 10.1080\/08820139.2019.1567533","DOI":"10.1080\/08820139.2019.1567533"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, et al. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nature Immunology. 2012;13(6):612-620. DOI: 10.1038\/ni.2305","DOI":"10.1038\/ni.2305"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Randall KL, Lambe T, Goodnow CC, Cornall RJ. The essential role of DOCK8 in humoral immunity. Dis Markers. 2010;29(3-4):141-150. DOI: 10.3233\/DMA-2010-0739","DOI":"10.1155\/2010\/143612"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Janssen E, Wilkie H, Geha RS. Macabre TH2 skewing in DOCK8 deficiency. J Allergy Clin Immunol. 2021;148(1):73-75. DOI: 10.1016\/j.jaci.2021.02.025","DOI":"10.1016\/j.jaci.2021.02.025"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Venegas-Montoya E, Staines-Boone AT, S\u00e1nchez-S\u00e1nchez LM, Garc\u00eda-Campos JA, C\u00f3rdova-Gurrola RA, Salazar-Galvez Y, et al. Case report: DOCK8 deficiency without hyper-IgE in a child with a large deletion. Front Pediatr. 2021;9:635322. DOI: 10.3389\/fped.2021.635322","DOI":"10.3389\/fped.2021.635322"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Chen Y, Chen Y, Yin W, Han H, Miller H, Li J, et al. The regulation of DOCK family proteins on T and B cells. J Leukoc Biol. 2021;109(2):383-394. DOI: 10.1002\/JLB.1MR0520-221RR","DOI":"10.1002\/JLB.1MR0520-221RR"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.jaci.2014.12.1945","article-title":"The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency","volume":"136","author":"Engelhardt","year":"2015","unstructured":"Engelhardt KR, Gertz ME, Keles S, Sch\u00e4ffer AA, Sigmund EC, Glocker C, et al. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015;136:402-412.","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Werner M, Jumaa H. DOCKing innate to adaptive signaling for persistent antibody production. Nature Immunoly. 2012;13(6):525-526. DOI: 10.1038\/ni.2317","DOI":"10.1038\/ni.2317"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, et al. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. Journal of Clinical Investigation. 2016;126(10):3837-3851. DOI: 10.1172\/JCI85774","DOI":"10.1172\/JCI85774"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Keles S, Jabara HH, Reisli I, McDonald DR, Barlan I, Hanna-Wakim R, et al. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: Rescue of severe herpetic infections with IFN-\uf0e1 2b therapy. J Allergy C. 2014 Jun;133(6):1753-1755. DOI: 10.1016\/j.jaci.2014.03.032","DOI":"10.1016\/j.jaci.2014.03.032"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Zhang Q, Jing H, Su HC. Recent advances in DOCK8 immunodeficiency syndrome. J Clin Immunol. 2016;36(5):441-449. DOI: 10.1007\/s10875-016-0296-z","DOI":"10.1007\/s10875-016-0296-z"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Kearney CJ, Randall KL, Oliaro J. DOCK8 regulates signal transduction events to control immunity. Cell Mol Immunol. 2017;14(5):406-411. DOI: 10.1038\/cmi.2017.9","DOI":"10.1038\/cmi.2017.9"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Broides A, Mandola AB, Levy J, Yerushalmi B, Pinsk V, Eldan M, et al. The clinical and laboratory spectrum of dedicator of cytokinesis 8 immunodeficiency syndrome in patients with a unique mutation. Immunol Res. 2017;65(3):651-657. DOI: 10.1007\/s12026-016-8883-x","DOI":"10.1007\/s12026-016-8883-x"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Eken A, Cansever M, Okus FZ, Erdem S, Nain E, Azizoglu ZB, et al. ILC3 deficiency and generalized ILC abnormalities in DOCK8\u2010deficient patients. Allergy. 2020;75(4):921-932. DOI: 10.1111\/all.14081","DOI":"10.1111\/all.14081"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Su HC. Dedicator of cytokinesis 8 (DOCK8) deficiency. Curr Opin Allergy Clin Immunol. 2010;10(6):515-520. DOI: 10.1097\/ACI.0b013e32833fd718","DOI":"10.1097\/ACI.0b013e32833fd718"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Pichard DC, Freeman AF, Cowen EW. Primary immunodeficiency update. J Am Acad Dermatol. 2015;73(3):355-364. DOI: 10.1016\/j.jaad.2015.01.055","DOI":"10.1016\/j.jaad.2015.01.055"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Lehman H, Gordon C. The skin as a window into primary immune deficiency diseases: atopic dermatitis and chronic mucocutaneous candidiasis. J Allergy Clin Immunol Pract. 2019;7(3):788-798. DOI: 10.1016\/j.jaip.2018.11.026","DOI":"10.1016\/j.jaip.2018.11.026"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Chu EY, Freeman AF, Jing H, Cowen EW, Davis J, Su HC, et al. Cutaneous manifestations of DOCK8 deficiency syndrome. Arch Dermatol. 2012;148(1):79-84. DOI: 10.1001\/archdermatol.2011.262","DOI":"10.1001\/archdermatol.2011.262"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Dimitrova D, Freeman AF. Current status of dedicator of cytokinesis-associated immunodeficiency. Dermatol Clin. 2017;35(1):11-19. DOI: 10.1016\/j.det.2016.07.002","DOI":"10.1016\/j.det.2016.07.002"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Relan M, Lehman HK. Common dermatologic manifestations of primary immune deficiencies. Curr Allergy Asthma Rep. 2014;14(12):480. DOI: 10.1007\/s11882-014-0480-2","DOI":"10.1007\/s11882-014-0480-2"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Al-Herz W, Zainal M, Nanda A. A prospective survey of skin manifestations in children with inborn errors of immunity from a national registry over 17 years. Front Immunol. 2021;12:751469. DOI: 10.3389\/fimmu.2021.751469","DOI":"10.3389\/fimmu.2021.751469"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nature Commun. 2017;8(1):13946. DOI: 10.1038\/ncomms13946","DOI":"10.1038\/ncomms13946"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"Jacob M, Bin Khalaf D, Alhissi S, Arnout R, Alsaud B, Al-Mousa H, et al. Quantitative profiling of cytokines and chemokines in DOCK8-deficient and atopic dermatitis patients. Allergy. 2019;74(2):370-379. DOI: 10.1111\/all.13610","DOI":"10.1111\/all.13610"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Belkaid Y, Tamoutounour S. The influence of skin microorganisms on cutaneous immunity. Nature Rev Immunol. 2016;16(6):353-366. DOI: 10.1038\/nri.2016.48","DOI":"10.1038\/nri.2016.48"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garc\u00eda JA, et al. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med. 2014;211(13):2549-266. DOI: 10.1084\/jem.20141307","DOI":"10.1084\/jem.20141307"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Lehman H. Skin manifestations of primary immune deficiency. Clin Rev Allergy Immunol. 2014;46(2):112-119. DOI: 10.1007\/s12016-013-8377-8","DOI":"10.1007\/s12016-013-8377-8"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Wu J, Hong L, Chen TX. Clinical manifestation of hyper IgE syndrome including otitis media. Curr Allergy Asthma Repo. 2018;18(10):51. DOI: 10.1007\/s11882-018-0806-6","DOI":"10.1007\/s11882-018-0806-6"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"Freeman AF, Milner JD. The child with elevated IgE and infection susceptibility. Curr Allergy Asthma Rep. 2020;20(11):65. DOI: 10.1007\/s11882-020-00964-y","DOI":"10.1007\/s11882-020-00964-y"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Jouanguy E, B\u00e9ziat V, Mogensen TH, Casanova JL, Tangye SG, Zhang SY. Human inborn errors of immunity to herpes viruses. Curr Opin Immunol. 2020;62:106-122. DOI: 10.1016\/j.coi.2020.01.004","DOI":"10.1016\/j.coi.2020.01.004"},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"Leiding JW, Holland SM. Warts and all: human papillomavirus in primary immunodeficiencies. J Allergy Clin Immunol. 2012;130(5):1030-1048. DOI: 10.1016\/j.jaci.2012.07.049","DOI":"10.1016\/j.jaci.2012.07.049"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Villanueva JCMM, Chan KW, Ong RC, Andaya AG, Lau YL, van Zelm MC, et al. Hyper IgE syndrome associated with warts: a first case of dedicator of cytokinesis 8 deficiency in the Philippines. Front Pediatr. 2020;8:604725. DOI: 10.3389\/fped.2020.604725","DOI":"10.3389\/fped.2020.604725"},{"key":"ref39","doi-asserted-by":"publisher","unstructured":"Yang J, Liu Y. Autosomal recessive hyper-IgE syndrome caused by DOCK8 gene mutation with new clinical features: a case report. BMC Neurology. 2021;21(1):288. DOI: 10.1186\/S12883-021-02324-3","DOI":"10.1186\/s12883-021-02324-3"},{"key":"ref40","doi-asserted-by":"publisher","unstructured":"Chen X, Anstey AV, Bugert JJ. Molluscum contagiosum virus infection. Lancet Infect Dis. 2013;13(10):877-888. DOI: 10.1016\/S1473-3099(13)70109-9","DOI":"10.1016\/S1473-3099(13)70109-9"},{"key":"ref41","doi-asserted-by":"publisher","unstructured":"Sanal O, Jing H, Ozgur T, Ayvaz D, Strauss-Albee DM, Ersoy-Evans S, et al. Additional diverse findings expand the clinical presentation of DOCK8 deficiency. J Clin Immunol. 2012;32(4):698-708. DOI: 10.1007\/s10875-012-9664-5","DOI":"10.1007\/s10875-012-9664-5"},{"key":"ref42","doi-asserted-by":"publisher","unstructured":"Saghafi S, Pourpak Z, Nussbaumer F, Fazlollahi MR, Houshmand M, Hamidieh AA, et al. DOCK8 deficiency in six Iranian patients. Clin Case Rep. 2016;4(6):593-600. DOI: 10.1002\/ccr3.574","DOI":"10.1002\/ccr3.574"},{"key":"ref43","doi-asserted-by":"publisher","unstructured":"Shah T, Cale C, Hadzic N, Jones A. Dedicator of cytokinesis 8 deficiency: a predisposition to sclerosing cholangitis. Clin Immunol. 2014;155(1):71-73. DOI: 10.1016\/j.clim.2014.09.001","DOI":"10.1016\/j.clim.2014.09.001"},{"key":"ref44","doi-asserted-by":"publisher","unstructured":"Ben-Yakov G, Sharma D, Cho MH, Shah NN, Hickstein D, Urban A, et al. Cryptosporidium infection in dedicator of cytokinesis 8 (DOCK 8) deficiency. J Allergy Clin Immunol Pract. 2020;8(10):3663-3666.e1. DOI: 10.1016\/j.jaip.2020.06.021","DOI":"10.1016\/j.jaip.2020.06.021"},{"key":"ref45","doi-asserted-by":"publisher","unstructured":"Saettini F, Fazio G, Moratto D, Galbiati M, Zucchini N, Ippolito D, et al. Case report: Hypomorphic function and somatic reversion in DOCK8 deficiency in one patient with two novel variants and sclerosing cholangitis. Font Immunol. 2021;12:573487. DOI: 10.3389\/fimmu.2021.673487.","DOI":"10.3389\/fimmu.2021.673487"},{"key":"ref46","doi-asserted-by":"publisher","unstructured":"Raoof S, Bondalapati P, Vydyula R, Ryu JH, Gupta N, Raoof S, et al. Cystic lung diseases. Chest. 2016;150(4):945-965. DOI: 10.1016\/j.chest.2016.04.026","DOI":"10.1016\/j.chest.2016.04.026"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Freeman AF, Olivier KN. Hyper-IgE syndromes and the lung. Clin Chest Med. 2016;37(3):557-567. DOI: 10.1016\/j.ccm.2016.04.016","DOI":"10.1016\/j.ccm.2016.04.016"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Lee EY, Vargas SO, Gaffin JM, Chou J, Park HJ, Winant AJ. Thoracic multidetector computed tomography findings of dedicator of cytokinesis 8 deficiency in children. J Thorac Imaging. 2021;36(5):304-309. DOI: 10.1097\/RTI.0000000000000587","DOI":"10.1097\/RTI.0000000000000587"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Aydin \u00d6F, Anlar B. Neurological manifestations of primary immunodeficiency diseases. Clin Pediatr. 2018;57(7):761-774. DOI: 10.1177\/0009922817737083","DOI":"10.1177\/0009922817737083"},{"key":"ref50","doi-asserted-by":"publisher","unstructured":"Rodrigues F, Graham Davies E, Harrison P, McLauchlin J, Karani J, Portmann B, et al. Liver disease in children with primary immunodeficiencies. J Pediatr. 2004;145(3):333-339. DOI: 10.1016\/j.jpeds.2004.05.037","DOI":"10.1016\/j.jpeds.2004.05.037"},{"key":"ref51","doi-asserted-by":"publisher","unstructured":"Papa R, Penco F, Volpi S, Gattorno M. Actin remodeling defects leading to autoinflammation and immune dysregulation. Front Immunol. 2021;11:604206. DOI: 10.3389\/fimmu.2020.604206","DOI":"10.3389\/fimmu.2020.604206"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"Al Mutairi M, Al-Mousa H, AlSaud B, Hawwari A, AlJoufan M, AlWesaibi A, et al. Grave aortic aneurysmal dilatation in DOCK8 deficiency. Mod Rheumatol. 2014;24(4):690-693. DOI: 10.3109\/14397595.2013.874735","DOI":"10.3109\/14397595.2013.874735"},{"key":"ref53","doi-asserted-by":"publisher","unstructured":"AlKhater SA. CNS vasculitis and stroke as a complication of DOCK8 deficiency: a case report. BMC Neurology. 2016;16(1):54. DOI: 10.1186\/s12883-016-0578-3","DOI":"10.1186\/s12883-016-0578-3"},{"key":"ref54","doi-asserted-by":"publisher","unstructured":"Yamazaki-Nakashimada M, Zaltzman-Girshevich S, Garc\u00eda-de la Puente S, De Le\u00f3n-Bojorge B, Espinosa-Padilla S, S\u00e1ez-de Ocariz M, et al. Hyper-IgE syndrome and autoimmunity in Mexican children. Pediatr Nephrol. 2006;21(8):1200-1205. DOI: 10.1007\/s00467-006-0178-3","DOI":"10.1007\/s00467-006-0178-3"},{"key":"ref55","doi-asserted-by":"publisher","unstructured":"Jouhadi Z, Khadir K, Ailal F, Bouayad K, Nadifi S, Engelhardt KR, et al. Ten-year follow-up of a DOCK8-deficient child with features of systemic lupus erythematosus. Pediatrics. 2014;134(5):e1458-e1463. DOI: 10.1542\/peds.2013-1383.","DOI":"10.1542\/peds.2013-1383"},{"key":"ref56","doi-asserted-by":"publisher","unstructured":"Shiozawa S, Tsumiyama K, Miyazaki Y, Uto K, Sakurai K, Nakashima T, et al. DOCK8-expressing T follicular helper cells newly generated beyond self-organized criticality cause systemic lupus erythematosus. iScience. 2022;25(1):103537. DOI: 10.1016\/j.isci.2021.103537","DOI":"10.1016\/j.isci.2021.103537"},{"key":"ref57","doi-asserted-by":"publisher","unstructured":"Seo E, Lee BH, Lee JH, Park YS, Im HJ, Lee J. Hematopoietic stem cell transplantation in an infant with dedicator of cytokinesis 8 (DOCK8) deficiency associated with systemic lupus erythematosus. Medicine (Baltimore). 2021;100(13):e20866. DOI: 10.1097\/MD.0000000000020866","DOI":"10.1097\/MD.0000000000020866"},{"key":"ref58","doi-asserted-by":"publisher","unstructured":"Takahashi K, Kohno T, Ajima R, Sasaki H, Minna JD, Fujiwara T, et al. Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer. Int J Oncol. 2006;28(2):321-328. DOI:10.3892\/ijo.28.2.321","DOI":"10.3892\/ijo.28.2.321"},{"key":"ref59","doi-asserted-by":"publisher","unstructured":"Nagayama K, Kohno T, Sato M, Arai Y, Minna JD, Yokota J. Homozygous deletion scanning of the lung cancer genome at a 100-kb resolution. Genes Chromosomes Cancer. 2007;46(11):1000-1010. DOI: 10.1002\/gcc.20485.","DOI":"10.1002\/gcc.20485"},{"key":"ref60","doi-asserted-by":"publisher","unstructured":"Kelaidi C, Tzotzola V, Polychronopoulou S. The paradigm of hematological malignant versus non-malignant manifestations, driven by primary immunodeficiencies: a complex interplay. Fam Cancer. 2021;20(4):363-380. DOI: 10.1007\/s10689-021-00266-w","DOI":"10.1007\/s10689-021-00266-w"},{"key":"ref61","doi-asserted-by":"publisher","unstructured":"Cekic S, Metin A, Aytekin C, Edeer-Karaca N, Baris S, Karali Y, et al. The evaluation of malignancies in Turkish primary immunodeficiency patients; a multicenter study. Pediatr Allergy Immunol. 2020;31(5):528-536. DOI: 10.1111\/pai.13231","DOI":"10.1111\/pai.13231"},{"key":"ref62","doi-asserted-by":"publisher","unstructured":"Ku\u015fkonmaz B, Ayvaz D, Bar\u0131\u015f S, \u00dcnal \u015e, Tezcan \u0130, U\u00e7kan D. Acute myeloid leukemia in a child with dedicator of cytokinesis 8 (DOCK8) deficiency. Pediatr Blood Cancer. 2017;64(12):e26695. DOI: 10.1002\/pbc.26695","DOI":"10.1002\/pbc.26695"},{"key":"ref63","doi-asserted-by":"publisher","unstructured":"Rubio\u2010Gonz\u00e1lez B, Frieden IJ, McCalmont TH, Dorsey M, Funk T, Pincus LB. Folliculotropic mycosis fungoides driven by DOCK8 immunodeficiency syndrome. Pediatr Dermatol. 2021;38(1):229-232. DOI: 10.1111\/pde.14424","DOI":"10.1111\/pde.14424"},{"key":"ref64","doi-asserted-by":"publisher","unstructured":"Dimitriades VR, Devlin V, Pittaluga S, Su HC, Holland SM, Wilson W, et al. DOCK 8 deficiency, EBV+ lymphomatoid granulomatosis, and intrafamilial variation in presentation. Front Pediatr. 2017;5:38. DOI: 10.3389\/fped.2017.00038","DOI":"10.3389\/fped.2017.00038"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Roschewski M, Wilson WH. Lymphomatoid granulomatosis. Cancer J. 2012;18(5):469-474. DOI: 10.1097\/PPO.0b013e31826c5e19","DOI":"10.1097\/PPO.0b013e31826c5e19"},{"key":"ref66","doi-asserted-by":"publisher","unstructured":"Buchbinder D, Kirov I, Danielson J, Shah NN, Freeman AF, Chavan RS, et al. Compound heterozygous DOCK8 mutations in a patient with B lymphoblastic leukemia and EBV-associated diffuse large B cell lymphoma. J Clin Immunol. 2019;39(6):592-595. DOI: 10.1007\/s10875-019-00663-y","DOI":"10.1007\/s10875-019-00663-y"},{"key":"ref67","doi-asserted-by":"publisher","unstructured":"Roschewski M, Wilson WH. Lymphomatoid granulomatosis. Cancer J. 2012 Sep;18(5):469-474. DOI: 10.1097\/PPO.0b013e31826c5e19","DOI":"10.1097\/PPO.0b013e31826c5e19"},{"key":"ref68","doi-asserted-by":"publisher","unstructured":"Kuriyama S, Majima Y, Egawa Y, Suzuki Y, Moriki T, Tokura Y. Cutaneous lymphomatoid granulomatosis with long-term absence of lung involvement. J Dermatol. 2019;46(2):e69-e70. DOI: 10.1111\/1346-8138.14548","DOI":"10.1111\/1346-8138.14548"},{"key":"ref69","doi-asserted-by":"publisher","unstructured":"Melani C, Jaffe ES, Wilson WH. Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder. Blood. 2020;135(16):1344-1352. DOI: 10.1182\/blood.2019000933","DOI":"10.1182\/blood.2019000933"},{"key":"ref70","doi-asserted-by":"publisher","unstructured":"Dunleavy K, Roschewski M, Wilson WH. Lymphomatoid granulomatosis and other Epstein-Barr virus associated lymphoproliferative processes. Curr Hematol Malig Rep. 2012;7(3):208-215. DOI: 10.1007\/s11899-012-0132-3","DOI":"10.1007\/s11899-012-0132-3"},{"key":"ref71","doi-asserted-by":"publisher","unstructured":"Aydin-Goker ET, Cagdas D, Bajin IY, Kukul MG, Aytekin ES, Orhan D, et al. Multicentric Castleman disease in a DOCK8\u2010deficient patient with Orf virus infection. Pediatr Allergy Immunol. 2022;33(1):e13666. DOI: 10.1111\/pai.13666","DOI":"10.1111\/pai.13666"},{"key":"ref72","doi-asserted-by":"publisher","unstructured":"Ma CS, Tangye SG. Flow cytometric-based analysis of defects in lymphocyte differentiation and function due to inborn errors of immunity. Front Immunol. 2019;10:2108. DOI: 10.3389\/fimmu.2019.02108","DOI":"10.3389\/fimmu.2019.02108"},{"key":"ref73","doi-asserted-by":"publisher","unstructured":"Okamoto K, Morio T. Inborn errors of immunity with eosinophilia. Allergol Int. 2021;70(4):415-420. DOI: 10.1016\/j.alit.2021.08.008","DOI":"10.1016\/j.alit.2021.08.008"},{"key":"ref74","doi-asserted-by":"publisher","unstructured":"Meshaal SS, el Hawary RE, Eldash A, Grimbacher B, Camacho-Ordonez N, Abd Elaziz DS, et al. Diagnosis of DOCK8 deficiency using flow cytometry biomarkers: an Egyptian center experience. Clin Immunol. 2018;195:36-44. DOI: 10.1016\/j.clim.2018.07.011","DOI":"10.1016\/j.clim.2018.07.011"},{"key":"ref75","doi-asserted-by":"publisher","unstructured":"Janssen E, Tsitsikov E, Al-Herz W, Lefranc G, Megarbane A, Dasouki M, et al. Flow cytometry biomarkers distinguish DOCK8 deficiency from severe atopic dermatitis. Clin Immunol. 2014;150(2):220-224. DOI: 10.1016\/j.clim.2013.12.006.","DOI":"10.1016\/j.clim.2013.12.006"},{"key":"ref76","doi-asserted-by":"publisher","unstructured":"Renner ED, Puck JM, Holland SM, Schmitt M, Weiss M, Frosch M, et al. Autosomal recessive hyperimmunoglobulin E syndrome: a distinct disease entity. J Pediatr. 2004;144(1):93-99. DOI: 10.1016\/S0022-3476(03)00449-9","DOI":"10.1016\/S0022-3476(03)00449-9"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, L\u00f3pez-Herrera G, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009;124(6):1289-1302. DOI: 10.1016\/j.jaci.2009.10.038","DOI":"10.1016\/j.jaci.2009.10.038"},{"key":"ref78","unstructured":"Dedicator of cytokinesis 8; DOCK8 [Internet]. Online Mendelian Inheritance in Man; c2022. Disponible en: https:\/\/www.omim.org\/entry\/611432?search=dock8&highlight=dock8"},{"key":"ref79","unstructured":"e!Ensembl [Internet]. Transcript: ENST00000432829.7 DOCK8-204; 2022. Disponible en: https:\/\/www.ensembl.org\/Homo_sapiens\/Transcript\/Summary?db=core;g=ENSG00000107099;r=9:214854-465259;t=ENST00000432829"},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"Kunimura K, Uruno T, Fukui Y. DOCK family proteins: key players in immune surveillance mechanisms. Int Immunol. 2020;32(1):5-15. DOI: 10.1093\/intimm\/dxz067","DOI":"10.1093\/intimm\/dxz067"},{"key":"ref81","doi-asserted-by":"publisher","unstructured":"Hara S, Kiyokawa E, Iemura S, Natsume T, Wassmer T, Cullen PJ, et al. The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent Mannose 6-phosphate receptor transport. Mol Biol Cell. 2008;19(9):3823-3835. DOI: 10.1091\/mbc.E08-03-0314","DOI":"10.1091\/mbc.e08-03-0314"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"C\u00f4t\u00e9 JF, Motoyama AB, Bush JA, Vuori K. A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling. Nat Cell Biol. 2005;7(8):797-807. DOI: 10.1038\/ncb1280","DOI":"10.1038\/ncb1280"},{"key":"ref83","doi-asserted-by":"publisher","unstructured":"Yousefnezhad S, Gharesouran J, Ghafouri-Fard S, Hosseinzadeh H, Ahmadian-Heris J, Jafari-Rouhi AH, et al. DOCK8-related immunodeficiency syndrome (DIDS): report of novel mutations in Iranian patients. J Mol Neurosci. 2021;71(12):2456-2461. DOI: 10.1007\/s12031-021-01843-5","DOI":"10.1007\/s12031-021-01843-5"},{"key":"ref84","doi-asserted-by":"publisher","unstructured":"Jing H, Zhang Q, Zhang Y, Hill BJ, Dove CG, Gelfand EW, et al. Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. J Allergy Clin Immunol. 2014;133(6):1667-1675. DOI: 10.1016\/j.jaci.2014.03.025","DOI":"10.1016\/j.jaci.2014.03.025"},{"key":"ref85","doi-asserted-by":"publisher","unstructured":"Alsum Z, Hawwari A, Alsmadi O, Al-Hissi S, Borrero E, Abu-staiteh A, et al. Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients. J Clin Immunol. 2013;33(1):55-67. DOI: 10.1007\/s10875-012-9769-x","DOI":"10.1007\/s10875-012-9769-x"},{"key":"ref86","doi-asserted-by":"publisher","unstructured":"Kienzler AK, van Schouwenburg PA, Taylor J, Marwah I, Sharma RU, Noakes C, et al. Hypomorphic function and somatic reversion of DOCK8 cause combined immunodeficiency without hyper-IgE. Clin Immunol. 2016;163:17-21. DOI: 10.1016\/j.clim.2015.12.003","DOI":"10.1016\/j.clim.2015.12.003"},{"key":"ref87","doi-asserted-by":"publisher","unstructured":"Burbank AJ, Shah SN, Montgomery M, Peden D, Tarrant TK, Weimer ET. Clinically focused exome sequencing identifies a homozygous mutation that confers DOCK8 deficiency. Pediatr Allergy Immunol. 2016;27(1):96-98. DOI: 10.1111\/pai.12451","DOI":"10.1111\/pai.12451"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"Al-Kzayer LFY, Al-Aradi HMH, Shigemura T, Sano K, Tanaka M, Hamada M, et al. DOCK8 mutation diagnosed using whole-exome sequencing of the dried blood spot-derived DNA: a case report of an Iraqi girl diagnosed in Japan. BMC Med Genet. 2019;20(1):114. DOI: 10.1186\/s12881-019-0837-4","DOI":"10.1186\/s12881-019-0837-4"},{"key":"ref89","doi-asserted-by":"publisher","unstructured":"Ponsford MJ, Klocperk A, Pulvirenti F, Dalm VASH, Milota T, Cinetto F, et al. Hyper-IgE in the allergy clinic--when is it primary immunodeficiency? Allergy. 2018;73(11):2122-2136. DOI: 10.1111\/all.13578","DOI":"10.1111\/all.13578"},{"key":"ref90","doi-asserted-by":"publisher","unstructured":"Tay TR, Bosco J, Aumann H, O'Hehir R, Hew M. Elevated total serum immunoglobulin E (> 1000 IU\/mL): implications? Intern Med J. 2016;46(7):846-849. DOI: 10.1111\/imj.13073.","DOI":"10.1111\/imj.13073"},{"key":"ref91","doi-asserted-by":"publisher","unstructured":"Frey-Jakobs S, Hartberger JM, Fliegauf M, Bossen C, Wehmeyer ML, Neubauer JC, et al. ZNF341 controls STAT3 expression and thereby immunocompetence. Sci Immunol. 2018;3(24):eaat4941. DOI: 10.1126\/sciimmunol.aat4941","DOI":"10.1126\/sciimmunol.aat4941"},{"key":"ref92","doi-asserted-by":"publisher","unstructured":"Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4(1):1. DOI: 10.1038\/s41572-018-0001-z","DOI":"10.1038\/s41572-018-0001-z"},{"key":"ref93","doi-asserted-by":"publisher","unstructured":"Castagnoli R, Lougaris V, Giardino G, Volpi S, Leonardi L, la Torre F, et al. Inborn errors of immunity with atopic phenotypes: a practical guide for allergists. World Allergy Organ J. 2021;14(2):100513. DOI: 10.1016\/j.waojou.2021.100513","DOI":"10.1016\/j.waojou.2021.100513"},{"key":"ref94","doi-asserted-by":"publisher","unstructured":"Al\u2010Shaikhly T, Ochs HD. Hyper IgE syndromes: clinical and molecular characteristics. Immunol Cell Biol. 2019;97(4):368-379. DOI: 10.1111\/imcb.12209","DOI":"10.1111\/imcb.12209"},{"key":"ref95","doi-asserted-by":"publisher","unstructured":"Papan C, Hagl B, Heinz V, Albert MH, Ehrt O, Sawalle-Belohradsky J, et al. Beneficial IFN-treatment of tumorous herpes simplex blepharoconjunctivitis in dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2014;133(5):1456-1458. DOI: 10.1016\/j.jaci.2014.02.008","DOI":"10.1016\/j.jaci.2014.02.008"},{"key":"ref96","doi-asserted-by":"publisher","unstructured":"Al-Zahrani D, Raddadi A, Massaad M, Keles S, Jabara HH, Chatila TA, et al. Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency. Clin Immunol. 2014;153(1):104-108. DOI: 10.1016\/j.clim.2014.04.005","DOI":"10.1016\/j.clim.2014.04.005"},{"key":"ref97","doi-asserted-by":"publisher","unstructured":"Sobh A, Bonilla FA. Vaccination in primary immunodeficiency disorders. J Allergy Clin Immunol Pract. 2016;4(6):1066-1075. DOI: 10.1016\/j.jaip.2016.09.012","DOI":"10.1016\/j.jaip.2016.09.012"},{"key":"ref98","doi-asserted-by":"publisher","unstructured":"Gomes N, Miranda J, Lopes S, Carneiro-Le\u00e3o L, Torres-Costa J, Baudrier T, et al. Omalizumab in the treatment of hyper-IgE syndrome: 2 case reports. J Investig Allergol Clin Immunol. 2020;30(3):191-192. DOI: 10.18176\/jiaci.0469","DOI":"10.18176\/jiaci.0469"},{"key":"ref99","doi-asserted-by":"publisher","unstructured":"Ollech A, Mashiah J, Lev A, Simon AJ, Somech R, Adam E, et al. Treatment options for DOCK8 deficiency\u2010related severe dermatitis. J Dermatol. 2021;48(9):1386-1393. DOI: 10.1111\/1346-8138.15955","DOI":"10.1111\/1346-8138.15955"},{"key":"ref100","doi-asserted-by":"publisher","unstructured":"Albert MH, Freeman AF. Wiskott-Aldrich Syndrome (WAS) and dedicator of cytokinesis 8- (DOCK8) deficiency. Front Pediatr. 2019;7:451. DOI: 10.3389\/fped.2019.00451","DOI":"10.3389\/fped.2019.00451"},{"key":"ref101","doi-asserted-by":"publisher","unstructured":"Slatter MA, Gennery AR. Hematopoietic cell transplantation in primary immunodeficiency - conventional and emerging indications. Expert Rev Clin Immunol. 2018;14(2):103-114. DOI: 10.1080\/1744666X.2018.1424627","DOI":"10.1080\/1744666X.2018.1424627"},{"key":"ref102","doi-asserted-by":"publisher","unstructured":"Al Shekaili L, Sheikh F, Al Gazlan S, Al Dhekri H, Al Mousa H, Al Ghonaium A, et al. Novel mutation in DOCK8-HIES with severe phenotype and successful transplantation. Clin Immunol. 2017;178:39-44. DOI: 10.1016\/j.clim.2016.08.002","DOI":"10.1016\/j.clim.2016.08.002"},{"key":"ref103","doi-asserted-by":"publisher","unstructured":"Happel CS, Stone KD, Freeman AF, Shah NN, Wang A, Lyons JJ, et al. Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8-deficient patients. J Allergy Clin Immunol. 2016;137(6):1895-1898.e5. DOI: 10.1016\/j.jaci.2015.11.017","DOI":"10.1016\/j.jaci.2015.11.017"},{"key":"ref104","doi-asserted-by":"publisher","unstructured":"Al-Herz W, Chu JI, van der Spek J, Raghupathy R, Massaad MJ, Keles S, et al. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016;138(3):852-859.e3. DOI: 10.1016\/j.jaci.2016.02.022","DOI":"10.1016\/j.jaci.2016.02.022"},{"key":"ref105","doi-asserted-by":"publisher","unstructured":"Vaseghi-Shanjani M, Smith KL, Sara RJ, Modi BP, Branch A, Sharma M, et al. Inborn errors of immunity manifesting as atopic disorders. J Allergy Clin Immunol. 2021;148(5):1130-1139. DOI: 10.1016\/j.jaci.2021.08.008","DOI":"10.1016\/j.jaci.2021.08.008"},{"key":"ref106","doi-asserted-by":"publisher","unstructured":"Cagdas D, Halacli SO, Tan C, Esenboga S, Karaatmaca B, Cetinkaya PG, et al. Diversity in serine\/threonine protein kinase-4 deficiency and review of the literature. J Allergy Clin Immunol Pract. 2021;9(10):3752-3766.e4. DOI: 10.1016\/j.jaip.2021.05.032","DOI":"10.1016\/j.jaip.2021.05.032"},{"key":"ref107","doi-asserted-by":"publisher","unstructured":"Zhang Q, Boisson B, B\u00e9ziat V, Puel A, Casanova JL. Human hyper-IgE syndrome: singular or plural? Mammalian Genome. 2018;29(7-8):603-617. DOI: 10.1007\/s00335-018-9767-2","DOI":"10.1007\/s00335-018-9767-2"},{"key":"ref108","doi-asserted-by":"publisher","unstructured":"Kolukisa B, Baser D, Akcam B, Danielson J, Bilgic Eltan S, Haliloglu Y, et al. Evolution and long\u2010term outcomes of combined immunodeficiency due to CARMIL2 deficiency. Allergy. 2022;77(3):1004-1019. DOI: 10.1111\/all.15010","DOI":"10.1111\/all.15010"},{"key":"ref109","doi-asserted-by":"publisher","unstructured":"Guo W, Feng X, Yang M, Shangguan Y, Shi P, Wang S, et al. Mycobacterium intracellulare infection associated with TYK2 deficiency: a case report and review of the literature. Infect Drug Resist. 2020;13:4347-4353. DOI: 10.2147\/IDR.S279438","DOI":"10.2147\/IDR.S279438"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1104\/1604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1104\/1605","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1104\/1604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T04:44:09Z","timestamp":1676177049000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,31]]},"references-count":110,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,6,10]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v69i1.1104","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2023,1,31]]}}}