{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T05:40:49Z","timestamp":1676526049418},"reference-count":8,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>Introducci\u00f3n: El eritema exudativo multiforme es una reacci\u00f3n de hipersensibilidad retardada poco frecuente asociada\u00a0con medicamentos. Las manifestaciones provocadas por hidroxicloroquina son excepcionales; sin embargo,\u00a0debido al incremento de su prescripci\u00f3n, por la reciente pandemia de SARS-CoV-2, las reacciones adversas se han\u00a0exacerbado.\nReporte de caso: Paciente femenina de 60 a\u00f1os, que acudi\u00f3 al servicio de Urgencias por un cuadro de exantema\u00a0eritematoso de una semana de evoluci\u00f3n, con afectaci\u00f3n hacia el tronco, la cara y las palmas de las manos. Los\u00a0estudios de laboratorio informaron: leucocitosis con neutrofilia y linfopenia, sin eosinofilia ni alteraci\u00f3n de las enzimas\u00a0hep\u00e1ticas. Las lesiones continuaron descendiendo hacia las extremidades, con posterior descamaci\u00f3n. Se\u00a0le indic\u00f3 prednisona 15 mg\/24 h durante tres d\u00edas, con disminuci\u00f3n a 10 mg\/24 h, hasta su nueva valoraci\u00f3n,\u00a0adem\u00e1s de antihistam\u00ednicos. Dos d\u00edas posteriores aparecieron nuevas lesiones maculares en la zona preesternal\u00a0y en la mucosa oral. Los estudios de laboratorio de control no mostraron alteraciones. La biopsia cut\u00e1nea inform\u00f3:\u00a0dermatitis de interfase vacuolar con espongiosis y paraqueratosis, compatible con eritema multiforme. Se llevaron\u00a0a cabo pruebas epicut\u00e1neas con meloxicam e hidroxicloroquina al 30% en agua y vaselina, ocluidos dos d\u00edas e\u00a0interpretados a las 48 y 96 horas, con resultado positivo para esta \u00faltima. Se estableci\u00f3 el diagn\u00f3stico de eritema\u00a0exudativo multiforme por hidroxicloroquina.\nConclusi\u00f3n: Este estudio confirma la eficacia de las pruebas epicut\u00e1neas en pacientes con reacciones de hipersensibilidad\u00a0retardada a hidroxicloroquina.<\/jats:p>","DOI":"10.29262\/ram.v69i3.1171","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T05:08:34Z","timestamp":1675314514000},"source":"Crossref","is-referenced-by-count":0,"title":["Eritema exudativo multiforme provocado por hidroxicloroquina, diagnosticado mediante pruebas epicut\u00e1neas: reporte de un caso"],"prefix":"10.29262","volume":"69","author":[{"given":"Maria Araceli","family":"Castro Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro Ra\u00fal","family":"Gratac\u00f3s G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Florido L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,2,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Bennardo L, Nistic\u00f2 SP, Dastoli S, Provenzano E, Napolitano M, Silvestri M et al. Erythema Multiforme and COVID-19: What Do We Know?. Medicina (Kaunas). 2021;57(8):828. https:\/\/doi.org\/10.3390\/medicina57080828","DOI":"10.3390\/medicina57080828"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Koumaki D, Koumaki V, Bertsias G, Boumpoucheropoulos S, Katoulis A, Stefanidou M, et al. Hydroxychloroquine-induced erythema multiforme. Clin Case Rep. 2020;8(3):578-579. https:\/\/doi.org\/10.1002\/ccr3.2648","DOI":"10.1002\/ccr3.2648"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Monte Serrano J, Crua\u00f1es Monferrer J, Garc\u00eda-Garc\u00eda M, Garc\u00eda-Gil MF. Hydroxychloroquine-induced erythema multiforme in a patient with COVID-19. Eritema multiforme inducido por hidroxicloroquina en paciente con COVID-19. Med Clin (Barc). 2020;155(5):231. https:\/\/doi.org\/10.1016\/j.medcli.2020.05.004","DOI":"10.1016\/j.medcli.2020.05.004"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Abou Assalie N, Durcan R, Durcan L, Petri MA. Hydroxychloroquine-Induced Erythema Multiforme. J Clin Rheumatol. 2017;23(2):127-128. doi: 10.1097\/RHU.0000000000000417","DOI":"10.1097\/RHU.0000000000000417"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Gisondi P, Piaserico S, Bordin C, Bellinato F, Tozzi F, Alaibac M, Girolomoni G, Naldi L. The safety profile of hydroxychloroquine: major cutaneous and extracutaneous adverse events. Clin Exp Rheumatol. 2021 Sep-Oct;39(5):1099-1107.","DOI":"10.55563\/clinexprheumatol\/styx9u"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Castro Jim\u00e9nez A, Navarrete Navarrete N, Gratac\u00f3s G\u00f3mez AR, Florido L\u00f3pez F, Garc\u00eda Rodr\u00edguez R, G\u00f3mez Torrijos E. First case of DRESS syndrome caused by hydroxychloroquine with a positive patch test. Contact Dermatitis. 2021;84(1):50-51. https:\/\/doi.org\/10.1111\/cod.13657","DOI":"10.1111\/cod.13657"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Garcia-Nunez I, Algaba-Marmol MA, Castro-Cost C. Erythema Multiforme After Intake of Risedronate: A Cross-Reactivity Study. J Investig Allergol Clin Immunol. 2021 Oct 25;31(5):457-8. https:\/\/doi.org\/10.18176\/jiaci.0668","DOI":"10.18176\/jiaci.0668"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Nin-Valencia A, Dom\u00ednguez-Ortega J, Caba\u00f1as R, S\u00e1nchez H, Fiandor A, Lluch M, Ramirez E, G\u00f3mez-Traseira C, Rodr\u00edguez A, Gonz\u00e1lez-Mu\u00f1oz M. The Lymphocyte Transformation Test in delayed hypersensitivity reactions induced by ibuprofen and\/or metamizole. J Investig Allergol Clin Immunol. 2022 Apr 12:0. Epub ahead of print. https:\/\/doi.org\/10.18176\/jiaci.0814","DOI":"10.18176\/jiaci.0814"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1171\/1743\/10110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T17:50:41Z","timestamp":1676483441000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1171"}},"subtitle":["Eritema Multiforme por hidroxicloroquina con pruebas epicut\u00e1neas positivas"],"short-title":[],"issued":{"date-parts":[[2023,2,1]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2,1]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v69i3.1171","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,1]]}}}