{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:25:45Z","timestamp":1767651945837,"version":"3.40.5"},"reference-count":36,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"Supl1","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RAM"],"abstract":"<jats:p>La pandemia de COVID-19 ha colapsado los sistemas de salud de muchos pa\u00edses del mundo y las comorbilidades en adultos han incrementado exponencialmente su mortalidad; respecto al asma, no se ha podido establecer una relaci\u00f3n determinante en la mortalidad. Las manifestaciones cl\u00ednicas del paciente con asma y SARS-CoV-2 se presentan con una amplia gama, desde asintom\u00e1ticas hasta las que experimentan insuficiencia respiratoria aguda. El m\u00e9todo m\u00e1s sensible para el diagn\u00f3stico de la infecci\u00f3n por SARS-CoV-2 es la RT-PCR. Las pruebas de ant\u00edgeno y serol\u00f3gicas son m\u00e1s r\u00e1pidas que la RT-PCR, pero menos sensibles. Los estudios radiol\u00f3gicos y la tomograf\u00eda computarizada de t\u00f3rax auxilian en el diagn\u00f3stico y seguimiento de la infecci\u00f3n por SARS-CoV-2. El uso de la espirometr\u00eda se restringe para el diagn\u00f3stico y seguimiento debido al alto riesgo de contagio. Se ha demostrado que la eosinofilia y la inflamaci\u00f3n TH2, debido a su efecto inmunol\u00f3gico antiv\u00edrico, son factores protectores contra SARS-CoV-2\/COVID-19 severo. Los pacientes con asma leve expresan menos receptores de la enzima convertidora de angiotensina (ECA2) y aquellos con asma neutrof\u00edlica expresan mayor proporci\u00f3n, lo que sugiere presentaciones m\u00e1s severas de COVID-19. El tratamiento convencional del asma modula la respuesta inmunitaria del SARS-CoV-2\/COVID-19, por lo cual, los pacientes con asma controlados tienen manifestaciones no graves de COVID-19, aunque los mecanismos no est\u00e1n claros.<\/jats:p>","DOI":"10.29262\/ram.v69isupl1.1009","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T21:17:43Z","timestamp":1641763063000},"page":"s15-s23","source":"Crossref","is-referenced-by-count":5,"title":["Asma y COVID-19"],"prefix":"10.29262","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9863-4196","authenticated-orcid":false,"given":"Jos\u00e9 Jes\u00fas","family":"L\u00f3pez-Tiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-8770","authenticated-orcid":false,"given":"Elvia Ang\u00e9lica","family":"Contreras-Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-2825","authenticated-orcid":false,"given":"Nancy Nayeli","family":"Cruz-Arellanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-6819","authenticated-orcid":false,"given":"Mario Alberto","family":"Camargo-Pirr\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6419-9077","authenticated-orcid":false,"given":"Erick Oswaldo","family":"Cabrera-Buend\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5437-4364","authenticated-orcid":false,"given":"Guadalupe Isadora","family":"Ram\u00edrez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9786-8476","authenticated-orcid":false,"given":"Guillermo","family":"Vega-Acevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2022,1,8]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Terry PD, Heidel RE, Dhand R. 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