{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:12:11Z","timestamp":1694646731539},"reference-count":16,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Antecedentes: La alergia a antibi\u00f3ticos notificada con m\u00e1s frecuencia es la penicilina. La falsa etiqueta de \"alergia\" a la penicilina afecta negativamente la calidad de vida del paciente y la atenci\u00f3n m\u00e9dica.\nObjetivo: \u00a0Determinar la frecuencia de alergia a penicilina y amoxicilina mediante pruebas de exposici\u00f3n in vivo, en pacientes con antecedente de reacci\u00f3n inmediata a esta clase de medicamentos.\nM\u00e9todos. \u00a0Estudio observacional, transversal, descriptivo y prolectivo en pacientes entre 12 y 60 a\u00f1os con antecedente de reacci\u00f3n inmediata a penicilina y\/o amoxicilina. Se realizaron pruebas cut\u00e1neas por prick e intrade\u0301rmicas con bencilpeniciloil polilisina y penicilina G, y prueba de reto oral con amoxicilina.\u00a0 La frecuencia de positividad y negatividad en estas pruebas fue calculado con un IC del 95%. Los resultados se analizaron en Epi info 7.2.5.0\nResultados.\u00a0 Se incluyeron 13 pacientes (10 mujeres), con una media de edad \u00a0de 39 an\u0303os (DE 12.14) y diagn\u00f3stico predominante de rinitis al\u00e9rgica (61,5%). En 84,6% de casos la \u00faltima reacci\u00f3n adversa a medicamentos ocurri\u00f3 10 a\u00f1os atr\u00e1s y en todos se manifest\u00f3 con urticaria. S\u00f3lo en cinco pacientes (38,4%) se corrobor\u00f3 alergia a penicilina y la reacci\u00f3n adversa m\u00e1s frecuente tras las pruebas in vivo fue prurito (23 %).\nConclusiones. La historia cl\u00ednica por s\u00ed sola no es suficiente, todos los pacientes con sospecha de alergia a penicilina deben ser evaluados mediante pruebas\u00a0 de exposici\u00f3n in vivo con los determinantes mayores y menores para corroborar o descartar alergia a esta clase farmacol\u00f3gica.<\/jats:p>","DOI":"10.29262\/ram.v70i3.1254","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:03:57Z","timestamp":1694505837000},"page":"205","source":"Crossref","is-referenced-by-count":0,"title":["Pruebas diagn\u00f3sticas in vivo en alergia inmediata a penicilina: estudio piloto"],"prefix":"10.29262","volume":"70","author":[{"given":"Dulce Mariel","family":"Ruiz S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Rivero Yeverino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Sergio","family":"Papaqui-Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrystopherson Gengyny","family":"Caballero-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida In\u00e9s","family":"L\u00f3pez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jes\u00fas","family":"Rios-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Flores-Gonzaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Villada-Villada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"54052","doi-asserted-by":"crossref","unstructured":"Reacciones al\u00e9rgicas a betalact\u00e1micos en pediatr\u00eda: recomendaciones para su diagn\u00f3stico y tratamiento Comit\u00e9 Nacional de Alergia. 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