{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T13:49:27Z","timestamp":1717163367058},"reference-count":1,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Antecedentes: El s\u00edndrome DRESS (Drug reaction with eosinophilia and systemic symptoms) es una reacci\u00f3n idiosincr\u00e1tica, se caracteriza por eosinofilia perif\u00e9rica y s\u00edntomas sist\u00e9micos: fiebre, exantema, linfadenopat\u00eda, hepatitis, linfocitos at\u00edpicos y elevaci\u00f3n de enzimas hep\u00e1ticas. La incidencia es de 1 por cada 10,000 exposiciones, mortalidad de 10 a 20%. El tratamiento se basa en la suspensi\u00f3n del f\u00e1rmaco sospechoso y en la aplicaci\u00f3n de esteroides.\nReporte de caso: Masculino de 42 a\u00f1os con los siguientes antecedentes de importancia. AHF: madre y padre con Diabetes Mellitus tipo 2. APP: Hipertensi\u00f3n Arterial, Diabetes Mellitus tipo 2, y alergia a picadura de abeja. Padecimiento Actual: Lo inicia posterior a 8 d\u00edas tras la ingesta de hidroxicloroquina por probable infecci\u00f3n por SARS-COV-2, con cefalea, edema facial y de cuello, dermatosis descamativa en tronco y extremidades superiores, acude a cl\u00ednica particular con evoluci\u00f3n t\u00f3rpida enviado a tercer nivel por aumento de edema facial y cuello, que amerito intubaci\u00f3n orotraqueal, manejo con esteroides intravenosos y antihistam\u00ednicos. Laboratorios a su ingreso: Leucocitos 20090, plaquetas 322 mil, eosinofilia (5%), elevaci\u00f3n de enzimas hep\u00e1ticas y lesi\u00f3n renal aguda, cumpliendo criterios J-SCAR. Se egresa por adecuada evoluci\u00f3n con seguimiento por Alergia e Inmunolog\u00eda Cl\u00ednica, el paciente persiste con lesiones descamativas posterior a 4 semanas y normalizaci\u00f3n de par\u00e1metros de laboratorios.\nConclusi\u00f3n: DRESS es una reacci\u00f3n adversa retardada. Es importante la presunci\u00f3n diagn\u00f3stica y la relaci\u00f3n causal con los f\u00e1rmacos por la alta tasa de mortalidad.<\/jats:p>","DOI":"10.29262\/ram.v70i3.1262","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:03:06Z","timestamp":1694505786000},"page":"201","source":"Crossref","is-referenced-by-count":1,"title":["Caso cl\u00ednico: sindrome de DRESS   por hidroxicloroquina"],"prefix":"10.29262","volume":"70","author":[{"given":"Yosahandi estefania","family":"Pacheco jimenez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"R\u00edos L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Caballero L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"L\u00f3pez Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Rivero Yeverino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Papaqui Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Armenta Morales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"54258","doi-asserted-by":"crossref","unstructured":"Calle, A. M., Aguirre, N., Ardila, J. C., & Cardona Villa, R. (2023). DRESS syndrome: A literature review and treatment algorithm. The World Allergy Organization journal, 16(3).","DOI":"10.1016\/j.waojou.2022.100673"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1262\/2083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1262\/2083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:03:15Z","timestamp":1694505795000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":1,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,11]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v70i3.1262","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,21]]}}}