{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T08:50:41Z","timestamp":1747212641264,"version":"3.40.5"},"reference-count":7,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Antecedentes: El eritema pigmentado fijo (EPF) es una reacci\u00f3n al\u00e9rgica medicamentosa, de la cual no se conoce con exactitud la fisiopatolog\u00eda. Es m\u00e1s frecuente en la mujer con localizaci\u00f3n en la cara. Presentaci\u00f3n cl\u00ednica: m\u00e1cula redonda u oval de color rojo-viol\u00e1ceo, bien delimitada, con edema con dolor, prurito y ardor. El diagn\u00f3stico es cl\u00ednico, contraindicado el reto oral por posible reacci\u00f3n grave. Al retirar el f\u00e1rmaco, queda una hiperpigmentaci\u00f3n residual viol\u00e1cea.\nReporte de caso: Femenina de 34 a\u00f1os con diagn\u00f3stico de rinitis al\u00e9rgica y asma, Recibi\u00f3 tratamiento con Ibuprofeno y cefalexina hace 1 mes debido a proceso infeccioso dental. Desde hace 2 semanas presenta lesiones dermatol\u00f3gicas caracterizadas por hiperpigmentaci\u00f3n debajo de p\u00e1rpados inferiores, acompa\u00f1ado de dolor, ardor y prurito. A la exploraci\u00f3n f\u00edsica en ambas regiones perioculares se observa pigmentaci\u00f3n bien delimitada rojo-viol\u00e1ceo. La prueba de reto no se justifica, la historia cl\u00ednica es el pilar diagn\u00f3stico. La indicaci\u00f3n es suspender el medicamento de inmediato y vigilancia continua.\nConclusi\u00f3n: El EPF es una reacci\u00f3n a medicamentos relacionada con el consumo de f\u00e1rmacos. Genera un desaf\u00edo para el diagn\u00f3stico debido al pobre conocimiento de las caracter\u00edsticas de la dermatosis y un deficiente interrogatorio cl\u00ednico y farmacol\u00f3gico. El abordaje del EPF requiere conocer las caracter\u00edsticas cl\u00ednicas de esta dermatosis, realizar el diagnostico diferencial con otras lesiones e indicar la suspensi\u00f3n del medicamento responsable.<\/jats:p>","DOI":"10.29262\/ram.v70i3.1268","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:02:33Z","timestamp":1694505753000},"page":"203","source":"Crossref","is-referenced-by-count":0,"title":["Eritema pigmentado fijo secundario a AINE: Reporte de caso"],"prefix":"10.29262","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-2084","authenticated-orcid":false,"given":"Bryan Eduardo","family":"Garc\u00eda L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Mondrag\u00f3n Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea Aidea","family":"Velasco Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Vel\u00e1zquez Samano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"54293","unstructured":"Villanueva OA, Ram\u00edrez G. Eritema pigmentado fijo secundario a ingesta de alopurinol."},{"key":"54294","doi-asserted-by":"crossref","unstructured":"Rev Cent Dermatol Pascua. 2021;30(1):20-23.","DOI":"10.35366\/100587"},{"key":"54295","unstructured":"L\u00f3pez R, Cruces C, P\u00e9rez R, Villa L, Guerrero A. Exantema fijo medicamentoso por"},{"key":"54296","unstructured":"paracetamol. Gerokomos. 2017;28(3):158-162."},{"key":"54297","unstructured":"Shaker G, Mehendale T, De La Rosa C. Fixed Drug Eruption: An Underrecognized"},{"key":"54298","unstructured":"Cutaneous Manifestation of a Drug Reaction in the Primary Care Setting. Cureus."},{"key":"54299","unstructured":";14(8):1-7."}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1268\/2085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1268\/2085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:02:37Z","timestamp":1694505757000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":7,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,11]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v70i3.1268","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2023,8,21]]}}}