{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T22:41:39Z","timestamp":1694644899122},"reference-count":1,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Objetivo: Evaluar el efecto de la modulaci\u00f3n farmacol\u00f3gica de HIF-1 en la expresi\u00f3n de IL-33 e IL-17 en un modelo murino de inflamaci\u00f3n al\u00e9rgica pulmonar (IAP) con diferentes grados de severidad.\nM\u00e9todos: 5 ratones\/grupo recibieron ovoalb\u00famina (OVA) 1(leve), 2(moderada) o 3(severa) retos v\u00eda i.t. previa sensibilizaci\u00f3n como alergeno, adem\u00e1s los grupos de inducci\u00f3n o inhibici\u00f3n de HIF-1\u03b1, recibieron EDHB (OVA+EDHB) i.p. o 2ME (OVA+2ME) i.t. respectivamente. Los grupos controles recibieron soluci\u00f3n salina (SS) de igual forma. Se realizaron tinciones de HE (infiltrado inflamatorio), PAS (producci\u00f3n de moco) e inmunohistoqu\u00edmicas de HIF-1\u03b1, IL-33, IL-17, analizando cuantitativamente por patolog\u00eda digital.\nResultados: Obtuvimos diferentes grados de severidad a mayor n\u00famero de retos, incrementando la expresi\u00f3n de HIF-1, correlacionando con la expresi\u00f3n de IL- 33\/IL-17. Aumentando o disminuyendo, respectivamente por la modulaci\u00f3n farmacol\u00f3gica.\nConclusiones: Lo anterior sugiere que la alta expresi\u00f3n de HIF-1 favorece la producci\u00f3n de IL-33 e IL-17 contribuyendo al da\u00f1o en el tejido pulmonar y la severidad de la enfermedad y estas pueden ser reguladas a trav\u00e9s de la modulaci\u00f3n de HIF-1.<\/jats:p>","DOI":"10.29262\/ram.v70i3.1273","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:01:47Z","timestamp":1694505707000},"page":"190","source":"Crossref","is-referenced-by-count":0,"title":["Regulaci\u00f3n de la expresi\u00f3n de IL-33 e IL-17 por la modulaci\u00f3n farmacol\u00f3gica de HIF-1 en un modelo murino de inflamaci\u00f3n al\u00e9rgica pulmonar"],"prefix":"10.29262","volume":"70","author":[{"given":"Guillermina J.","family":"Baay-Guzman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron Pavel","family":"Rodr\u00edguez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Anaya Estrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Jimenez Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JE","family":"Cocoletzi Bautista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hern\u00e1ndez Cueto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Luria Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"54437","unstructured":"NA"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1273\/2072","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1273\/2072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T08:01:51Z","timestamp":1694505711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":1,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9,11]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v70i3.1273","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,21]]}}}