{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:31:26Z","timestamp":1705537886303},"reference-count":54,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>La alergia alimentaria es una reacci\u00f3n adversa a ciertos los alimentos que han demostrado \"mecanismos\u00a0inmunol\u00f3gicos\u201d; por lo tanto, este t\u00e9rmino abarca tanto las alergias alimentarias mediadas o no por la inmunoglobulina\u00a0E (IgE). El mecanismo fisiopatol\u00f3gico com\u00fan entre las formas de alergia a alimentos mediadas\u00a0o no por IgE se encuentra en la falla de la tolerancia cl\u00ednica e inmunol\u00f3gica hacia ese alimento. La inducci\u00f3n\u00a0y el mantenimiento de la tolerancia inmunol\u00f3gica depende de la generaci\u00f3n activa de c\u00e9lulas T reguladoras\u00a0espec\u00edficas para ant\u00edgenos alimentarios. Este proceso est\u00e1 influenciado por factores gen\u00e9ticos (genes FOXP3)\u00a0y epigen\u00e9ticos condicionados por el medio ambiente (dieta, microbiota y sus productos). Puesto que el microbioma\u00a0intestinal normalmente puede promover la tolerancia oral, la evidencia actual sugiere que las perturbaciones\u00a0del microbioma pueden correlacionarse, o incluso predisponer, con la alergia alimentaria. Comprender\u00a0el mecanismo pat\u00f3geno subyacente a las alergias alimentarias mediadas por IgE permite implementar las\u00a0medidas destinadas a restaurar la tolerancia cl\u00ednica e inmunol\u00f3gica. El conocimiento de los mecanismos de la\u00a0alergia alimentaria mejorar\u00e1 la perspectiva de los pacientes con alergias alimentarias inmediatas m\u00e1s graves\u00a0y la anafilaxia, adem\u00e1s de quienes tienes tienen enfermedades concomitantes (dermatitis at\u00f3pica, esofagitis\u00a0eosinof\u00edlica y los EGEID).<\/jats:p>","DOI":"10.29262\/ram.v70i4.1309","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T12:38:18Z","timestamp":1705495098000},"page":"225-229","source":"Crossref","is-referenced-by-count":0,"title":["Fisiopatolog\u00eda de la alergia alimentaria"],"prefix":"10.29262","volume":"70","author":[{"given":"Marylin","family":"Valentin Rostan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dory","family":"Mora-Bogado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"55915","doi-asserted-by":"crossref","unstructured":"Muraro A, Werfel T, et al. 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