{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T21:54:43Z","timestamp":1777240483876,"version":"3.51.4"},"reference-count":31,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2023,12,31]],"date-time":"2023-12-31T00:00:00Z","timestamp":1703980800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>El t\u00e9rmino intolerancia alimentaria se ha utilizado de manera inespec\u00edfica para definir una amplia gama de\u00a0trastornos relacionados con la ingesta de alimentos. Recientemente se recomend\u00f3 el uso de la expresi\u00f3n\u00a0\u201creacciones adversas no inmunol\u00f3gicas a alimentos\u201d (RANIAs) como una definici\u00f3n cl\u00ednica m\u00e1s correcta. Los\u00a0mecanismos fisiopatol\u00f3gicos pueden ser diversos, a veces desconocidos, y no existen pruebas diagn\u00f3sticas\u00a0validadas, por lo que es dif\u00edcil obtener datos certeros. Las manifestaciones cl\u00ednicas de las reacciones adversas\u00a0no inmunol\u00f3gicas a alimentos afectan a m\u00e1s de un \u00f3rgano o sistema; y los s\u00edntomas gastrointestinales (dolor,\u00a0distensi\u00f3n abdominal, flatulencias y diarrea) son los m\u00e1s frecuentes. Las reacciones adversas no inmunol\u00f3gicas\u00a0a alimentos se dividen en independientes y dependientes de factores del hu\u00e9sped. Los alimentos pueden\u00a0contener productos qu\u00edmicos con actividad farmacol\u00f3gica y estar presentes en forma natural, como las aminas\u00a0vasoactivas (histamina) y los salicilatos, o a\u00f1adirse para su conservaci\u00f3n, mejorar la apariencia o el sabor\u00a0(glutamato monos\u00f3dico, tartrazina, sulfitos y benzoatos). En algunos casos, este tipo de reacciones pueden\u00a0ser similares, desde el punto de vista cl\u00ednico, a las reacciones de hipersensibilidad. El consumo de alcohol concomitante\u00a0puede empeorar los s\u00edntomas, al inhibir la degradaci\u00f3n de la histamina y aumentar la permeabilidad\u00a0intestinal. En pacientes con diagn\u00f3stico de reacciones adversas no inmunol\u00f3gicas por alimentos es importante\u00a0descartar algunos problemas de \u00edndole psicol\u00f3gica: aversiones o trastornos de la conducta alimentaria.\u00a0<\/jats:p>","DOI":"10.29262\/ram.v70i4.1337","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T12:36:14Z","timestamp":1705494974000},"page":"265-268","source":"Crossref","is-referenced-by-count":2,"title":["Intolerancia alimentaria"],"prefix":"10.29262","volume":"70","author":[{"given":"Mauricio","family":"Colella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio Alberto","family":"Salvador Parisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2023,12,31]]},"reference":[{"key":"56594","doi-asserted-by":"crossref","unstructured":"Gargano D, Appanna R, et al. 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