{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:15:40Z","timestamp":1740179740667,"version":"3.37.3"},"reference-count":1,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"1","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Introduction: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with a high daily burden of symptoms and a significant impact on health-related quality of life (HRQoL) (HRQoL). To date, the clinical and demographic characteristics of Colombian patients with CRSwNP are unknown.\r\nObjectives: The aim of this study is to present the baseline clinical and demographic characteristics of CRSwNP patients over the age of 18 enrolled in a Patient Support Program (PSP) prior to biologic treatment.\r\nMethodology: Descriptive, cross-sectional study performed in a Colombian CRSwNP asthma PSP sponsored by Sanofi from Aug-2021 to Jul-2022. Data was collected from CRSwNP patients, prior to the start of Dupilumab treatment, who consented to the use of their data. \u00a0The following information was reported: Age, reporting city, treating medical specialty, comorbidities, and persistence of treatment.\r\nResults: 339 patients were included, 171 (50.4%) were women and 168 (49.6%) were men (Figure 1). The mean age at Dupilumab treatment initiation was 52.4 years. 62.8% began treatment during adulthood (26-59y), while 34.1% started at elderly (+60y) and 3.1% were young adults (18-25y). Most cases (29.7%) were included in Bogot\u00e1, followed by Antioquia (19%), Valle del Cauca (7.3%) and the remaining 44% nationwide (Figure 2).\r\nComorbidities were present in 67.1% of the patients, with diagnosis of allergic rhinitis, atopic dermatitis, asthma, and other non-type 2 inflammatory diseases (Figure 3). Nasal surgical history was present in 89.6% of the patients, most of them with one to three previous surgeries (Figure 4).\r\nContinuous treatment was observed in 70.3% of patients for 6 to 12 months, in 21.3% for more than 12 months and in 8.4% for less than 6 months. The most frequently treating medical specialty was otorhinolaryngology (79,6%), followed by allergology (16%) and other medical professionals (4.4%).\r\nConclusions:\r\n\r\nThere is concordance with the literature on a higher presentation of the disease in women than in men.\r\nThere is a large proportion of patients with nasal surgical history and type 2 inflammatory comorbidities by the moment of biologic treatment initiation.\r\nThe care and identification of CRSwNP colombian patients is mainly provided by otorhinolaryngologists, followed by allergologists.\r\n<\/jats:p>","DOI":"10.29262\/ram.v71i1.1349","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T21:50:37Z","timestamp":1714168237000},"page":"77","source":"Crossref","is-referenced-by-count":0,"title":["Caracterizaci\u00f3n cl\u00ednica y demogr\u00e1fica de pacientes colombianos con rinosinusitis cr\u00f3nica con poliposis nasal"],"prefix":"10.29262","volume":"71","author":[{"given":"Sergio","family":"Londo\u00f1o","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Penagos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Cadena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Rodr\u00edguez Ord\u00f3\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"57391","unstructured":"."}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1349\/2196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1349\/2197","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1349\/2196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T21:50:59Z","timestamp":1714168259000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":1,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,4,23]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v71i1.1349","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}