{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:58:39Z","timestamp":1787025519038,"version":"build-2736575974"},"reference-count":22,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Objectives: To evaluate the impact of cholecalciferol (D3) supplementation using clinical and paraclinical variables in patients with RA and vitamin D insufficiency and deficiency.\nMethods: A randomized, double-blind, placebo-controlled study included patients from 5 to 40 years with a diagnosis of RA and vitamin D insufficiency and deficiency. They were supplemented for 8 weeks with 4000 or 5000 IU, depending on age. Total nasal symptoms score (TNSS) was measured monthly and 25(OH)D3 levels at baseline and at the end of the study.\nResults: A total of 31 patients were included, with a mean age of 18.19 years. In the active group, there was a significant improvement in symptomatology with respect to the TNSS score and an increase in serum vitamin D levels (p &lt; 0.01). There were no adverse reactions with cholecalciferol or placebo.\nConclusions: Supplementing patients with vitamin D3, at the evaluated dose, together with conventional treatment for allergic rhinitis results in symptoms and quality of life improvement in patients with this disease.\nKeywords: Allergic rhinitis, Vitamin D, Placebo, Cholecalciferol, Supplementation.<\/jats:p>","DOI":"10.29262\/ram.v71i2.1282","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:20:32Z","timestamp":1719926432000},"page":"85-90","source":"Crossref","is-referenced-by-count":2,"title":["Efecto de la suplementaci\u00f3n con vitamina D en pacientes mexicanos con rinitis al\u00e9rgica","Therapeutic effect of vitamin D supplementation in mexican patients with allergic rhinitis"],"prefix":"10.29262","volume":"71","author":[{"given":"Daniela","family":"Rivero-Yeverino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan Higgins","family":"Payan D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida In\u00e9s","family":"L\u00f3pez Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Sergio","family":"Papaqui Tapia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystopherson Gengyny","family":"Caballero L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jes\u00fas","family":"R\u00edos L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos David","family":"L\u00f3pez Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johav Yael","family":"S\u00e1nchez Villalobos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Ortega-Jorga Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"\u00c1lvarez Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Villada Villada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"54854","doi-asserted-by":"crossref","unstructured":"Schuler Iv CF, Montejo JM. Allergic Rhinitis in Children and Adolescents. Immunol Allergy Clin North Am. 2021;41(4):613-625. doi:10.1016\/j.iac.2021.07.010","DOI":"10.1016\/j.iac.2021.07.010"},{"key":"54855","doi-asserted-by":"crossref","unstructured":"Bousquet J, Anto JM, Bachert C, et al. Allergic rhinitis. Nat Rev Dis Primers. 2020;6(1):95. Published 2020 Dec 3. doi:10.1038\/s41572-020-00227-0","DOI":"10.1038\/s41572-020-00227-0"},{"key":"54856","unstructured":"Cat\u00e1logo maestro de gu\u00edas de pr\u00e1ctica cl\u00ednica. GU\u00cdA DE PR\u00c1CTICA CL\u00cdNICA GPC Diagn\u00f3stico y tratamiento de RINITIS AL\u00c9RGICA [Internet]. Ciudad de M\u00e9xico; 2017 Disponible en: http:\/\/www.cenetec.salud.gob.mx\/contenidos\/gpc\/catalogoMaestroGPC.html"},{"key":"54857","doi-asserted-by":"crossref","unstructured":"Bikle D, Christakos S. New aspects of vitamin D metabolism and action - addressing the skin as source and target. Nat Rev Endocrinol. 2020;16(4):234-252. doi:10.1038\/s41574-019-0312-5","DOI":"10.1038\/s41574-019-0312-5"},{"key":"54858","doi-asserted-by":"crossref","unstructured":"Saponaro F, Saba A, Zucchi R. An Update on Vitamin D Metabolism. Int J Mol Sci. 2020;21(18):6573. Published 2020 Sep 8. doi:10.3390\/ijms21186573","DOI":"10.3390\/ijms21186573"},{"key":"54859","doi-asserted-by":"crossref","unstructured":"Rivero-Yeverino D, L\u00f3pez-Garc\u00eda AI, Caballero-L\u00f3pez CG, et al. Vitamina D y alergia respiratoria: estado del arte [Vitamin D and respiratory allergy: state of the art]. Rev Alerg Mex. 2022;69 Suppl 1:s46-s54. doi:10.29262\/ram.v69iSupl1.1033","DOI":"10.29262\/ram.v69iSupl1.1033"},{"key":"54860","doi-asserted-by":"crossref","unstructured":"Murdaca G, Allegra A, Tonacci A, Musolino C, Ricciardi L, Gangemi S. Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases. Biomedicines. 2022;10(8):1877. 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Eur J Clin Nutr. 2020;74(11):1498-1513. doi:10.1038\/s41430-020-0558-y","DOI":"10.1038\/s41430-020-0558-y"},{"key":"54864","doi-asserted-by":"crossref","unstructured":"Murdaca G, Allegra A, Tonacci A, Musolino C, Ricciardi L, Gangemi S. Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases. Biomedicines. 2022;10(8):1877. Published 2022 Aug 3. doi:10.3390\/biomedicines10081877","DOI":"10.3390\/biomedicines10081877"},{"key":"54865","doi-asserted-by":"crossref","unstructured":"Salmanpour F, Kian N, Samieefar N, Khazeei Tabari MA, Rezaei N. Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives. J Immunol Res. 2022;2022:6735900. Published 2022 Jul 15. doi:10.1155\/2022\/6735900","DOI":"10.1155\/2022\/6735900"},{"key":"54866","unstructured":"Ruiz M\u00e1rquez IP, Rivero Yeverino D, L\u00f3pez Garc\u00eda AI, Cabellero L\u00f3pez CG, Arana Mu\u00f1oz O, Papaqui Tapia JS. Asociaci\u00f3n de estatus de vitamina D con persistencia y severidad de rinitis al\u00e9rgica. Benemerita Universidad Autonoma de Puebla; 2018."},{"key":"54867","doi-asserted-by":"crossref","unstructured":"Bedolla-Barajas M, L\u00f3pez-Hern\u00e1ndez JC, Garc\u00eda-Padilla LF, et al. Prevalencia de insuficiencia y deficiencia de vitamina D en adultos mexicanos con asma al\u00e9rgica [Prevalence of vitamin D insufficiency and deficiency in Mexican adults with allergic asthma]. Rev Alerg Mex. 2017;64(2):178-187. doi:10.29262\/ram.v64i2.255","DOI":"10.29262\/ram.v64i2.255"},{"key":"54868","doi-asserted-by":"crossref","unstructured":"Li Q, Zhou Q, Zhang G, et al. Vitamin D Supplementation and Allergic Diseases during Childhood: A Systematic Review and Meta-Analysis. Nutrients. 2022;14(19):3947. Published 2022 Sep 23. doi:10.3390\/nu14193947","DOI":"10.3390\/nu14193947"},{"key":"54869","doi-asserted-by":"crossref","unstructured":"Rizzoli R. 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