{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:21:34Z","timestamp":1767864094108,"version":"3.49.0"},"reference-count":81,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Severe asthma is an entity with a complex diagnosis, requiring an adequate differential diagnosis and identification of endotypes for a correct approach and therapeutic process. In the present review, we show a synthesis of the current literature on the diagnosis, pathophysiology, and management of severe asthma, having critically analyzed the evidence in search engines such as Medline, Scopus, and Embase.\nKeywords: Bronchial asthma; Allergy and immunology; Biological products.<\/jats:p>","DOI":"10.29262\/ram.v71i2.1283","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T16:34:41Z","timestamp":1719938081000},"page":"114-127","source":"Crossref","is-referenced-by-count":1,"title":["Asma grave: fisiopatolog\u00eda, diagn\u00f3stico y tratamiento","Severe asthma: Pathophysiology, diagnosis, and treatment"],"prefix":"10.29262","volume":"71","author":[{"given":"Jos\u00e9 E.","family":"Gereda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"De Arruda-Chaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Larco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Runzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"55351","unstructured":"Global Initiative for Ashtma. Global Strategy for Ashtma Management and Prevention. www.ginasthma.org"},{"key":"55352","unstructured":"GEMA 5.2. Gu\u00eda Espa\u00f1ola para el Manejo del Asma. Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica. 2022;"},{"key":"55353","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.12.007"},{"key":"55354","doi-asserted-by":"publisher","DOI":"10.36416\/1806-3756\/e20220176"},{"key":"55355","doi-asserted-by":"publisher","DOI":"10.1038\/nri3786"},{"key":"55356","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5753524"},{"key":"55357","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00576-2021"},{"key":"55358","doi-asserted-by":"publisher","DOI":"10.1111\/all.14526"},{"key":"55359","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.051"},{"key":"55360","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.004"},{"key":"55361","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33005-3"},{"key":"55362","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2019.04.007"},{"key":"55363","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.LSC-2022.39"},{"key":"55364","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2019.01.004"},{"key":"55365","doi-asserted-by":"publisher","DOI":"10.1152\/advan.00053.2018"},{"key":"55366","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08894-x"},{"key":"55367","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.018"},{"key":"55368","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0006-6"},{"key":"55369","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2019.04.018"},{"key":"55370","doi-asserted-by":"publisher","DOI":"10.35366\/97499"},{"key":"55371","doi-asserted-by":"publisher","DOI":"10.3390\/genes12060801"},{"key":"55372","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.05.031"},{"key":"55373","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202009-3631CI"},{"key":"55374","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.008"},{"key":"55375","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0725"},{"key":"55376","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2019.10.011"},{"key":"55377","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2019.1622714"},{"key":"55378","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0111-2018"},{"key":"55379","doi-asserted-by":"publisher","DOI":"10.1111\/all.15054"},{"key":"55380","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934398"},{"key":"55381","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbres.2019.08.001"},{"key":"55382","doi-asserted-by":"publisher","DOI":"10.1183\/2312508X.10023118"},{"key":"55383","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2022.05.009"},{"key":"55384","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000640"},{"key":"55385","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-022-02038-3"},{"key":"55386","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.11.016"},{"key":"55387","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.01.015"},{"key":"55388","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12149"},{"key":"55389","doi-asserted-by":"publisher","DOI":"10.3390\/jof7080631"},{"key":"55390","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8693-0"},{"key":"55391","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25212"},{"key":"55392","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25120"},{"key":"55393","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13532"},{"key":"55394","doi-asserted-by":"publisher","DOI":"10.1111\/pai.13168"},{"key":"55395","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30399-4"},{"key":"55396","unstructured":"Fainardi V, Saglani S. An approach to the management of children with problematic severe asthma. Acta Biomed. Sep 7 2020;91(3):e2020055. doi:10.23750\/abm.v91i3.9603"},{"key":"55397","doi-asserted-by":"publisher","DOI":"10.15586\/aei.v49i2.65"},{"key":"55398","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2018.10.005"},{"key":"55399","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.12.027"},{"key":"55400","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.793452"},{"key":"55401","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2020.02.007"},{"key":"55402","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0067-2021"},{"key":"55403","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050650"},{"key":"55404","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25061"},{"key":"55405","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24554"},{"key":"55406","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052652"},{"key":"55407","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2022.4.43.20210756"},{"key":"55408","doi-asserted-by":"publisher","DOI":"10.1111\/all.13749"},{"key":"55409","unstructured":"Busse WW, Haselkorn T, Ros\u00e9n K, Trzaskoma BL, Ortiz B, Szefler SJ. Greater Treatment Benefit with Omalizumab in Children with Increased Asthma Severity: Exploratory Analyses from the"},{"key":"55410","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.12.045"},{"key":"55411","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30406-5"},{"key":"55412","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.07.058"},{"key":"55413","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2022.02.017"},{"key":"55414","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S297273"},{"key":"55415","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2019.101830"},{"key":"55416","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121822"},{"key":"55417","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-01952-8"},{"key":"55418","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2020.201.1_MeetingAbstracts.A3028"},{"key":"55419","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30344-2"},{"key":"55420","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1678228"},{"key":"55421","unstructured":"1164\/ajrccm-conference.2018.197.1_MeetingAbstracts.A2490"},{"key":"55422","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1251-3"},{"key":"55423","doi-asserted-by":"publisher","DOI":"10.1111\/all.15056"},{"key":"55424","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-019-1134-7"},{"key":"55425","doi-asserted-by":"publisher","DOI":"10.1177\/17534666221107313"},{"key":"55426","unstructured":"Charles D, Shanley J, Temple SN, Rattu A, Khaleva E, Roberts G. Real-world efficacy of treatment with benralizumab, dupilumab, mepolizumab and reslizumab for severe asthma: A"},{"key":"55427","doi-asserted-by":"publisher","DOI":"10.1111\/cea.14112"},{"key":"55428","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.1680"},{"key":"55429","doi-asserted-by":"publisher","DOI":"10.1111\/all.14872"},{"key":"55430","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12176"},{"key":"55431","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13809"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1283\/2228","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1283\/2232","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1283\/2228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T18:25:04Z","timestamp":1733509504000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":81,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,21]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v71i2.1283","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6,30]]}}}