{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T22:16:12Z","timestamp":1775340972944,"version":"3.50.1"},"reference-count":34,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Objective: Estimate the prevalence of dermatological manifestations in Mexican patients with common variable immunodeficiency.\nMethods: Cross-sectional and retrospective study, based on the analysis of records of patients with a diagnosis of common variable immunodeficiency, treated at the Siglo XXI National Medical Center (Mexican Social Security Institute), according to the criteria of the European Society of Immunodeficiencies (ESID). and of which only 3 had a genetic diagnosis with the following mutations: IRF2, CTLA4 and PIK-3, belonging to the Immunodeficiency Clinic of the National Medical Center Siglo XXI (IMSS), to evaluate dermatological manifestations, review of laboratory tests: IgA, IgM, IgG and type of replacement therapy with Immunoglobulin. The statistical analysis was carried out with the SPSS program; Descriptive statistics were used to analyze the data, according to the type of variable to be analyzed.\nResults: 36 patients were included, of which 55.5% were women; with median age 34 years (18-94). The prevalence of dermatological manifestations was 70% (n = 25). 30.5% had a history of infectious dermatosis and 39.5% had a history of non-infectious dermatosis. The most common dermatosis was irritant contact dermatitis in 13.8% of patients. All received replacement therapy with human immunoglobulin, 33.3% intravenously and the rest subcutaneously.\nConclusions: Common variable immunodeficiency is an inborn error of immunity, with different clinical manifestations in various organs and systems (the skin is one of these). Dermatological manifestations are not usually described in patients with common variable immunodeficiency; However, it is important to identify them due to their relationship with certain complications (increased risk of superinfection), due to skin disruption and biological therapies.\nKeywords: Antibody immunodeficiency; Common variable immunodeficiency; skin diseases.<\/jats:p>","DOI":"10.29262\/ram.v71i2.1296","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T17:20:38Z","timestamp":1719940838000},"page":"91-95","source":"Crossref","is-referenced-by-count":1,"title":["Prevalencia de manifestaciones dermatol\u00f3gicas en pacientes con inmunodeficiencia com\u00fan variable","Espa\u00f1ol Prevalence of dermatological manifestations in common variable immunodeficiency patients"],"prefix":"10.29262","volume":"71","author":[{"given":"Brenda","family":"Guendulain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Mar\u00eda","family":"O`\u00b4 Farrill Romanillos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2024,6,30]]},"reference":[{"key":"57766","doi-asserted-by":"crossref","unstructured":"Chapel H, Lucas M, Lee M, et al. 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The Indian Journal of Pediatrics 2016; 83 (4): 338-344. doi: 10.1007\/s12098-016- 2038-x","DOI":"10.1007\/s12098-016-2038-x"},{"key":"57774","unstructured":"Caba\u00f1ero-Navalon MD, Garcia-Bustos V, Nu\u00f1ez-Beltran M, et al. Current clinical spectrum of common variable immunodeficiency"},{"key":"57775","doi-asserted-by":"crossref","unstructured":"in Spain: The multicentric nationwide GTEM-SEMICVID registry. Front Immunol 2022; 13. doi: 10.3389\/fimmu.2022.1033666","DOI":"10.3389\/fimmu.2022.1033666"},{"key":"57776","doi-asserted-by":"crossref","unstructured":"Iglesias-Alzueta J, Matamoros-Flor\u00ed N. Inmunodeficiencia variable com\u00fan. Revisi\u00f3n. Allergol Immunopathol (Madr) 2001; 29 (3): 113-118. doi: 10.1016\/S0301-0546(01)79029-5","DOI":"10.1016\/S0301-0546(01)79029-5"},{"key":"57777","unstructured":"LASID Latin American Society for Immunodeficiencies. https:\/\/lasidregistry.org\/."},{"key":"57778","doi-asserted-by":"crossref","unstructured":"Bousfiha A, Jeddane L, Picard C, et al. Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. J Clin Immunol 2020; 40 (1): 66-81. doi: 10.1007\/s10875-020-00758-x","DOI":"10.1007\/s10875-020-00758-x"},{"key":"57779","unstructured":"Soler-Palac\u00edn P. Inmunodeficiencias primarias. Congreso de Actualizaci\u00f3n Pediatr\u00eda 2020. Published online 2020:311-320."},{"key":"57780","doi-asserted-by":"crossref","unstructured":"Tam JS, Routes JM. Common Variable Immunodeficiency. 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