{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T04:20:52Z","timestamp":1744258852566,"version":"3.40.4"},"reference-count":10,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Antecedentes: La neutropenia cong\u00e9nita es una inmunodeficiencia primaria caracterizada por una disminuci\u00f3n en el recuento de neutr\u00f3filos. Se clasifica en leve, moderada o grave. Dentro de las opciones de tratamiento se incluye el trasplante de c\u00e9lulas progenitoras hematopoy\u00e9ticas; no obstante, la enfermedad de injerto contra hu\u00e9sped supone una complicaci\u00f3n importante.\nReporte de caso: Paciente de 2 a\u00f1os de edad, con antecedentes m\u00e9dicos de neutropenia cong\u00e9nita. Curs\u00f3 con abscesos en la piel cabelluda y celulitis preseptal, tratados satisfactoriamente. Luego de la evaluaci\u00f3n multidisciplinaria, se inici\u00f3 el protocolo para recibir trasplante alog\u00e9nico de c\u00e9lulas progenitoras hematopoy\u00e9ticas de donador no relacionado. Se estableci\u00f3 el diagn\u00f3stico de enfermedad de injerto contra hu\u00e9sped, que complic\u00f3 el pron\u00f3stico y, finalmente, dio como resultado el fallecimiento de la paciente.\nConclusi\u00f3n: La enfermedad de injerto contra hu\u00e9sped sigue siendo una complicaci\u00f3n importante en pacientes que reciben trasplantes alog\u00e9nicos de c\u00e9lulas progenitoras hematopoy\u00e9ticas. La identificaci\u00f3n, abordaje y tratamiento tiene relevancia cl\u00ednica, debido a la elevada morbilidad y mortalidad asociadas.\nPalabras clave: Neutropenia cong\u00e9nita; Trasplante de c\u00e9lulas progenitoras hematopoy\u00e9ticas; Enfermedad de injerto contra hu\u00e9sped.<\/jats:p>","DOI":"10.29262\/ram.v71i4.1405","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T02:58:15Z","timestamp":1735268295000},"page":"268-271","source":"Crossref","is-referenced-by-count":0,"title":["Neutropenia cong\u00e9nita y enfermedad de injerto contra hu\u00e9sped aguda postrasplante en un lactante. Reporte de caso","Congenital neutropenia and acute graft-versus-host disease in an infant. A case report"],"prefix":"10.29262","volume":"71","author":[{"given":"Cristian Jes\u00fas","family":"Huchim-Pe\u00f1a","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiliano","family":"Catana-Gallegos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas Esteban Ambrosio","family":"Pacheco-Sierra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Nayibe Getseman\u00ed Mart\u00edn-Burgos.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"59886","unstructured":"Justiz-Vaillant AA. Neutropenia - StatPearls - NCBI Bookshelf. National Center for Biotechnology Information. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507702\/?report=reader."},{"key":"59887","unstructured":"Seoane-Reula ME, de Arriba-M\u00e9ndez S. Diagn\u00f3stico y manejo de las inmunodeficiencias primarias en ni\u00f1os. Protoc diagn ter pediatr. 2019; 2: 415-35."},{"key":"59888","doi-asserted-by":"crossref","unstructured":"Guzm\u00e1n-Cotaya R, Baeza-Bastarrachea R, Espinosa-Padilla SE. Neutropenia cong\u00e9nita. Alerg Asma Inmunol Pediatr 2021; 30 (1): 24-27. doi: 10.35366\/100114","DOI":"10.35366\/100114"},{"key":"59889","doi-asserted-by":"crossref","unstructured":"Skokowa J, Dale DC, Touw IP, Zeidler C, et al. Severe congenital neutropenias. Nat Rev Dis Primers 2017; 3 (1). doi: 10.1038\/nrdp.2017.32","DOI":"10.1038\/nrdp.2017.32"},{"key":"59890","doi-asserted-by":"crossref","unstructured":"Malard F, Holler E, Sandmaier BM, Huang H, et al. Acute graft-versus-host disease. Nat Rev Dis Primers 2023; 9 (1): 27. doi: 10.1038\/s41572-023-00438-1","DOI":"10.1038\/s41572-023-00438-1"},{"key":"59891","doi-asserted-by":"crossref","unstructured":"Moreno DF, Cid J. Enfermedad del injerto contra el receptor. Medicina Clin 2019; 152 (1): 22-28. doi: 10.1016\/j.medcli.2018.07.012","DOI":"10.1016\/j.medcli.2018.07.012"},{"key":"59892","doi-asserted-by":"crossref","unstructured":"Ballester-S\u00e1nchez R, Navarro-Mira M, Sanz-Caballer J, Botella-Estrada R. Aproximaci\u00f3n a la enfermedad injerto contra hu\u00e9sped cut\u00e1nea. Actas Dermo Sifiliogr 2016; 107 (3): 183-193. doi: 10.1016\/j.ad.2015.10.003","DOI":"10.1016\/j.ad.2015.10.003"},{"key":"59893","doi-asserted-by":"crossref","unstructured":"Jaramillo-Esparza CM, Consuelo-S\u00e1nchez A, Acosta-Rodr\u00edguez-Bueno CP, et al. Enfermedad injerto contra hu\u00e9sped gastrointestinal y hep\u00e1tico en pacientes pedi\u00e1tricos con trasplante de c\u00e9lulas progenitoras hematopoy\u00e9ticas en el Hospital Infantil de M\u00e9xico Federico G\u00f3mez. Rev Gastroenterol Mex. 2018; 83 (4): 385-392. doi: 10.1016\/j.rgmx.2017.10.002","DOI":"10.1016\/j.rgmx.2017.10.002"},{"key":"59894","doi-asserted-by":"crossref","unstructured":"Hashmi H, Bhandari S, Dhanoa J, et al. Clinical Outcomes Using Mycophenolate and Tacrolimus for Graft-versus-Host Disease Prophylaxis in Patients Undergoing Allogeneic Stem Cell Transplant: A Single Institution Experience. Cureus 2020; 12 (2): e6893. doi:10.7759\/cureus.6893","DOI":"10.7759\/cureus.6893"},{"key":"59895","doi-asserted-by":"crossref","unstructured":"Yucebay F, Matthews C, Puto M, et al. Tocilizumab as first-line therapy for steroid-refractory acute graft-versus-host-disease: analysis of a single-center experience. Leuk Amp Lymphoma 2019; 60 (9): 2223-2229. doi: 10.1080\/10428194.2019.1573996","DOI":"10.1080\/10428194.2019.1573996"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1405\/2248","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1405\/2315","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1405\/2248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T15:54:09Z","timestamp":1744214049000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12,26]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v71i4.1405","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}