{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T05:42:29Z","timestamp":1758346949059,"version":"3.44.0"},"reference-count":23,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["revistaalergia.mx"],"crossmark-restriction":true},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Objetivo: Determinar las caracter\u00edsticas cl\u00ednicas, epidemiol\u00f3gicas y factores asociados con inmunosupresi\u00f3n en ni\u00f1os y ni\u00f1as con VIH.\nM\u00e9todos: Estudio observacional, anal\u00edtico y transversal, efectuado en pacientes que ingresaron al Centro Ambulatorio para la Prevenci\u00f3n y Atenci\u00f3n en SIDA e Infecciones de Transmisi\u00f3n Sexual del Estado de Puebla. El an\u00e1lisis estad\u00edstico incluy\u00f3 porcentajes, frecuencias, promedios, desviaci\u00f3n est\u00e1ndar y medianas; an\u00e1lisis inferencial con c2 y regresi\u00f3n log\u00edstica univariada. Para el an\u00e1lisis de los datos de utiliz\u00f3 el programa Statistical Package, for the Social Sciencies 24.\nResultados: Se registraron 83 pacientes de 0 a 17 a\u00f1os (media de 7 a\u00f1os; DE \u00b1 6.3), con promedio de edad al diagn\u00f3stico de 2.6 a\u00f1os. Se encontr\u00f3 un 90% de transmisi\u00f3n vertical; mujeres 47% y hombres 53%. Las enfermedades m\u00e1s frecuentes fueron: infecciones de repetici\u00f3n, linfadenopat\u00eda, diarrea; se informaron 4 casos de tuberculosis, desnutrici\u00f3n 35%. Categor\u00eda cl\u00ednica: N 25%, A 66%. Categor\u00eda inmunol\u00f3gica: 1-72%, 2-13%. Los factores asociados con inmunosupresi\u00f3n fueron: transmisi\u00f3n vertical (p &lt; 0.008) y concentraci\u00f3n de CD4 (p &lt; 0.007).\nConclusiones: Conocer las caracter\u00edsticas que describen el VIH\/SIDA pedi\u00e1trico, adem\u00e1s de las manifestaciones cl\u00ednicas y sus limitantes, puede orientar a instalar mejoras en la atenci\u00f3n y seguimiento, y por ende el pron\u00f3stico de los ni\u00f1os.\nPalabras clave: Inmunosupresi\u00f3n; Virus de inmunodeficiencia humana (VIH); S\u00edndrome de inmunodeficiencia adquirida (SIDA); Infecciones de repetici\u00f3n; Tuberculosis; Linfadenopat\u00eda.<\/jats:p>","DOI":"10.29262\/ram.v72i2.1440","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T10:54:23Z","timestamp":1751626463000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.29262\/ram.crossmark","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Inmunodeficiencia secundaria de ni\u00f1os con VIH, caracter\u00edsticas cl\u00ednico-epidemiol\u00f3gicas\u00a0 y factores asociados a inmunosupresi\u00f3n, en Puebla M\u00e9xico.&lt;\/b&gt;","&lt;b&gt;Secondary immunodeficiency of children with HIV, clinical-epidemiological characteristics and factors associated with immunosuppression, in Puebla Mexico.&lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-138X","authenticated-orcid":false,"given":"Mar\u00eda del Roc\u00edo","family":"Hern\u00e1ndez-Morales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-9593","authenticated-orcid":false,"given":"Juvenal","family":"Salgado-Valencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-8039","authenticated-orcid":false,"given":"Eleazar","family":"Mancilla-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2022-5688","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Espinosa-Texis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8238-1297","authenticated-orcid":false,"given":"Elizabeth","family":"Papaqui-Lim\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7913-5945","authenticated-orcid":false,"given":"Estefan\u00eda","family":"Alavez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0885-4867","authenticated-orcid":false,"given":"Ana Karen","family":"Castellanos-Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"62994","unstructured":"1. Marti\u0301nez MI, Berzosa A, Navarro ML, Fortuny GC. Infeccio\u0301n por el virus de la inmunodeficiencia humana (VIH) en Pediatri\u0301a. Protoc Diagn Ter Pediatr 2023; 2: 387-400."},{"key":"62995","unstructured":"2. ONUSIDA. Hoja informativa -\u00daltimas estad\u00edsticas sobre el estado de la epidemia de sida. Ginebra: UNAIDS; 2024. https:\/\/www.unaids.org\/es\/resources\/fact-sheet"},{"key":"62996","unstructured":"3. CENSIDA. Epidemiolog\u00eda Registro Nacional de casos de VIH y sida. M\u00e9xico: CENSIDA; 2024. https:\/\/www.gob.mx\/censida\/documentos\/epidemiologia-registro-nacional-de-casos-de-sida"},{"key":"62997","doi-asserted-by":"crossref","unstructured":"4. Vallejo B\u00c1, Lobo AH, Garc\u00eda IC, et al. Follow-up for 3 years of a pediatric population diagnosed in 2018 with mother-to-child transmission of HIV in 8 Latin American countries in the PLANTAIDS cohort. 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