{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T05:51:36Z","timestamp":1758347496594,"version":"3.44.0"},"reference-count":12,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"2","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["revistaalergia.mx"],"crossmark-restriction":true},"short-container-title":["Rev Alerg Mex"],"abstract":"Objetivo: Evaluar la reactividad cruzada entre Sco m 5 y prote\u00ednas de artr\u00f3podos mediante an\u00e1lisis in silico e\u00a0identificar posibles ep\u00edtopes de uni\u00f3n a IgE.\nM\u00e9todos: La homolog\u00eda de Sco m 5 y 15 al\u00e9rgenos de artr\u00f3podos (Vespula, Polistes, Polybia, Solenopsis, Brachyponera,\u00a0Phoneutria y Dermatophagoides) se evalu\u00f3 con el servidor ALLERMATCH y PRALINE para alineamientos\u00a0pareados y m\u00faltiples, respectivamente. Los \u00e1rboles filogen\u00e9ticos se realizaron a trav\u00e9s del programa\u00a0Molecular Evolutionary Genetics Analysis (MEGA). La predicci\u00f3n de ep\u00edtopes se efectu\u00f3 con el servidor Ellipro. La\u00a0visualizaci\u00f3n de las prote\u00ednas se llev\u00f3 a cabo con Pymol.\u00a0\nResultados: El alineamiento m\u00faltiple arroj\u00f3 una identidad del 50% y los alineamientos pareados entre Sco m\u00a05 y las prote\u00ednas de artr\u00f3podos mostraron homolog\u00eda diversa. Dos ep\u00edtopes lineales y uno conformacional\u00a0se identificaron en Sco m 5, muy conservados en las prote\u00ednas de artr\u00f3podos estudiadas, como las abejas,\u00a0avispas y hormigas.\nConclusi\u00f3n: La alta homolog\u00eda entre Sco m 5 y los al\u00e9rgenos de otros artr\u00f3podos facilita la posible reactividad\u00a0cruzada. La identificaci\u00f3n de potenciales ep\u00edtopes en regiones conservadas sustenta esta idea y sugieren puntos importantes para blancos terap\u00e9uticos en las alergias desencadenadas por venenos de artr\u00f3podos, especialmente\u00a0Scolopendra spp. Es necesario emprender estudios in vitro e in vivo para demostrar estos hallazgos.\u00a0\nPalabras clave: Prote\u00ednas de art\u00f3podos; IgE; Ep\u00edtopes; Al\u00e9rgenos de artr\u00f3podos; Vespula; Polistes; Polybia; Solenopsis;\u00a0Brachyponera; Phoneutria; Dermatophagoides; Prote\u00edna de veneno con alta concentraci\u00f3n de ciste\u00edna;\u00a0alergia; An\u00e1lisis in silico.<\/jats:p>","DOI":"10.29262\/ram.v72i2.1460","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T10:54:23Z","timestamp":1751626463000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.29262\/ram.crossmark","source":"Crossref","is-referenced-by-count":0,"title":["<b>Mimetismo molecular entre el principal al\u00e9rgeno del ciempi\u00e9s (<i>Scolopendra subspinipes<\/i>) Sco M 5 y prote\u00ednas de fuentes alerg\u00e9nicas. An\u00e1lisis <i>in silico<\/i><\/b>","<b>Molecular mimicry between the major allergen of the centipede <i>(<\/i><i>Scolopendra subspinipes<\/i><i>)<\/i> Sco M 5 and proteins from allergenic sources. <i>In silico <\/i>analysis.<\/b>"],"prefix":"10.29262","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7460-3427","authenticated-orcid":false,"given":"Andres","family":"S\u00e1nchez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-2886","authenticated-orcid":false,"given":"Giovanny","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5751-4825","authenticated-orcid":false,"given":"Jos\u00e9","family":"Dussan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-0541","authenticated-orcid":false,"given":"Marlon","family":"M\u00fanera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-783X","authenticated-orcid":false,"given":"Jorge Mario","family":"S\u00e1nchez-Caraballo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"63047","doi-asserted-by":"crossref","unstructured":"1. S\u00e1nchez J, S\u00e1nchez A, Cardona R. Exposici\u00f3n y sensibilizaci\u00f3n a insectos en pacientes al\u00e9rgicos en el tr\u00f3pico. Biom\u00e9dica 2018; 38 (Sup. 2): 80-6. https:\/\/doi.org\/10.7705\/biomedica.v38i3.3801","DOI":"10.7705\/biomedica.v38i3.3801"},{"key":"63048","doi-asserted-by":"crossref","unstructured":"2. S\u00e1nchez J, Cardona R, Caraballo L, Serrano C, et al. Inmunoterapia con al\u00e9rgenos: mecanismos de acci\u00f3n, impacto terap\u00e9utico y socioecon\u00f3mico Consenso de la Asociaci\u00f3n Colombiana de Alergias, Asma e Inmunolog\u00eda. Biom\u00e9dica (Bogot\u00e1) 2016; 463-74. http:\/\/www.revistabiomedica.org\/index.php\/biomedica\/article\/view\/3183","DOI":"10.7705\/biomedica.v36i3.3183"},{"key":"63049","doi-asserted-by":"crossref","unstructured":"3. Emiliani Y, S\u00e1nchez A, Munera M, S\u00e1nchez J, et al. In silico analysis of cross reactivity among phospholipases from Hymenoptera species. F1000Res 2021; 10: 2. https:\/\/doi.org\/10.12688\/f1000research.27089.2","DOI":"10.12688\/f1000research.27089.1"},{"key":"63050","doi-asserted-by":"crossref","unstructured":"4. Washio K, Masaki T, Fujii S, Hatakeyama M, et al. Anaphylaxis caused by a centipede bite: A \u201ctrue\u201d type-I allergic reaction. Allergol Int 2018; 67 (3): 419-20. https:\/\/doi.org\/10.1016\/j.alit.2018.01.005","DOI":"10.1016\/j.alit.2018.01.005"},{"key":"63051","unstructured":"5. Ross EJ, Jamal Z, Yee J. Centipede Envenomation. En: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542312\/"},{"key":"63052","doi-asserted-by":"crossref","unstructured":"6. Lan XQ, Zhao F, Wang QQ, Li JH, et al. Isolation and characterization of the major centipede allergen Sco m 5 from Scolopendra subspinipes mutilans. Allergol Int 2021; 70 (1): 121-8. https:\/\/doi.org\/10.1016\/j.alit.2020.06.003","DOI":"10.1016\/j.alit.2020.06.003"},{"key":"63053","doi-asserted-by":"crossref","unstructured":"7. Sudharson S, Kalic T, Hafner C, Breiteneder H. Newly defined allergens in the WHO\/IUIS Allergen Nomenclature Database during 01\/2019-03\/2021. Allergy 2021; 76 (11): 3359-73. https:\/\/doi.org\/10.1111\/all.15021","DOI":"10.1111\/all.15021"},{"key":"63054","doi-asserted-by":"crossref","unstructured":"8. S\u00e1nchez A, Cardona R, Munera M, S\u00e1nchez J. Identification of antigenic epitopes of thyroperoxidase, thyroglobulin and interleukin-24. Exploration of cross-reactivity with environmental allergens and possible role in urticaria and hypothyroidism. Immunol letters 2020; 220: 71-78","DOI":"10.1016\/j.imlet.2020.02.003"},{"key":"63055","doi-asserted-by":"crossref","unstructured":"9. Han Y, Kamau PM, Lai R, Luo L. Bioactive Peptides and Proteins from Centipede Venoms. Molecules 2022; 27 (14): 4423. https:\/\/doi.org\/10.3390\/molecules27144423","DOI":"10.3390\/molecules27144423"},{"key":"63056","doi-asserted-by":"crossref","unstructured":"10. Balit CR, Harvey MS, Waldock JM, Isbister GK. Prospective study of centipede bites in Australia. J Toxicol Clin Toxicol 2004; 42 (1): 41-8. https:\/\/doi.org\/10.1081\/clt-120028743","DOI":"10.1081\/CLT-120028743"},{"key":"63057","doi-asserted-by":"crossref","unstructured":"11. Perez-Riverol A, Lasa AM, Dos Santos-Pinto JRA, Palma MS. Insect venom phospholipases A1 and A2: Roles in the envenoming process and allergy. Insect Biochem Mol Biol 2019; 105: 10-24. https:\/\/doi.org\/10.1016\/j.ibmb.2018.12.011","DOI":"10.1016\/j.ibmb.2018.12.011"},{"key":"63058","doi-asserted-by":"crossref","unstructured":"12. Hoffman DR, Sakell RH, Schmidt M. Sol i 1, the phospholipase allergen of imported fire ant venom. 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