{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:58:29Z","timestamp":1759334309952,"version":"build-2065373602"},"reference-count":3,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"Introducci\u00f3n: La inmunodeficiencia com\u00fan variable (IDCV) es la inmunodeficiencia sintom\u00e1tica m\u00e1s com\u00fan en adultos, diagnosticada por exclusi\u00f3n en casos de hipogammaglobulinemia sin causa identificable. Sus manifestaciones var\u00edan desde infecciones recurrentes hasta autoinmunidad y riesgo de malignidad.\nReporte de caso: Paciente femenina de 11 a\u00f1os, previamente sana, originaria y residente del rancho El Nogal, en Arandas, Jalisco, una comunidad de aproximadamente 250 habitantes. Sin antecedentes heredofamiliares de relevancia; no se conoce consanguinidad ni presencia de enfermedades gen\u00e9ticas en la familia. Evoluci\u00f3n: Tras traumatismo en pierna izquierda, desarrolla osteomielitis. A su ingreso se detecta pancitopenia, adenomegalias, hepatoesplenomegalia, abscesos con cultivo positivo a Staphylococcus aureus. Se inicia abordaje para detectar errores innatos de la inmunidad evidenci\u00e1ndose disminuci\u00f3n de inmunoglobulina G y A. Debido a la infecci\u00f3n sist\u00e9mica grave, se administra inmunoglobulina intravenosa a 1 gramo\/ kilogramo y se ampl\u00eda el estudio inmunol\u00f3gico, detect\u00e1ndose alteraciones en la subpoblaci\u00f3n de linfocitos con disminuci\u00f3n de CD19+: 71 mm\u00b3, CD3+: 915 mm\u00b3, T CD4+ CD45RA+ (v\u00edrgenes): 92 mm\u00b3, c\u00e9lulas B de memoria totales 3%, sin cambio de isotipo 2.5%, con cambio de isotipo 0.5%, plasmoblastos 0.3% y CD21 bajo 9%, clasific\u00e1ndose como una inmunodeficiencia com\u00fan variable Freiburg 1B y se inicia inmunoglobulina intravenosa mensual a dosis 400 miligramos\/kilogramo. La paciente respondi\u00f3 favorablemente al tratamiento con inmunoglobulina, sin presentar infecciones graves posteriores. Se mantiene estable y en control por inmunolog\u00eda.\nConclusi\u00f3n: La IDCV, aunque m\u00e1s frecuente en adultos, puede debutar en edad pedi\u00e1trica. La sepsis por S. aureus como manifestaci\u00f3n inicial como en el caso de la paciente, debe alertar sobre posibles inmunodeficiencias subyacentes. Este caso destaca la importancia de sospechar inmunodeficiencias primarias en pacientes con infecciones graves, subrayando la necesidad de un diagn\u00f3stico y tratamiento tempranos para optimizar el pron\u00f3stico.\nPalabras clave: Inmunodeficiencia com\u00fan variable; Hipogammaglobulinemia; Staphylococcus aureus; Osteomielitis; Sepsis.<\/jats:p>","DOI":"10.29262\/ram.v72i3.1497","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:26:04Z","timestamp":1759242364000},"page":"236","source":"Crossref","is-referenced-by-count":0,"title":["<b>Sepsis por <\/b><b><i>Staphylococcus aureus <\/i><\/b><b>como manifestaci\u00f3n inicial de inmunodeficiencia com\u00fan variable <\/b>","<b><i>Staphylococcus aureus <\/i>sepsis as an initial manifestation of common variable immunodeficiency\u00a0<\/b>"],"prefix":"10.29262","volume":"72","author":[{"given":"Saira Marlene","family":"Cabrera Arias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"62539","doi-asserted-by":"crossref","unstructured":"Berr\u00f3n-Ruiz L, O'Farrill-Romanillos PM, L\u00f3pez-Herrera G, Vivas-Rosales IJ. Inmunodeficiencia com\u00fan variable y su asociaci\u00f3n con defectos en c\u00e9lulas B de memoria [Common variable immunodeficiency and its association with memory B-cell defects]. Rev Alerg Mex. 2018 Apr-Jun;65(2):171-177. Spanish. doi: 10.29262\/ram.v65i2.356. PMID: 29983014.","DOI":"10.29262\/ram.v65i2.356"},{"key":"62540","doi-asserted-by":"crossref","unstructured":"Chawla S, Barman P, Tyagi R, Jindal AK, Sharma S, Rawat A, Singh S. Autoimmune Cytopenias in Common Variable Immunodeficiency Are a Diagnostic and Therapeutic Conundrum: An Update. Front Immunol. 2022 Jun 20;13:869466. doi: 10.3389\/fimmu.2022.869466. PMID: 35795667; PMCID: PMC9251126.","DOI":"10.3389\/fimmu.2022.869466"},{"key":"62541","doi-asserted-by":"crossref","unstructured":"Pacillo L, Giardino G, Amodio D, Giancotta C, Rivalta B, Rotulo GA, Manno EC, Cifaldi C, Palumbo G, Pignata C, Palma P, Rossi P, Finocchi A, Cancrini C. Targeted treatment of autoimmune cytopenias in primary immunodeficiencies. Front Immunol. 2022 Aug 16;13:911385. doi: 10.3389\/fimmu.2022.911385. PMID: 36052091; PMCID: PMC9426461.","DOI":"10.3389\/fimmu.2022.911385"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1497\/2772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1497\/2772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:26:05Z","timestamp":1759242365000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":3,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i3.1497","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}