{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:49:03Z","timestamp":1776185343196,"version":"3.50.1"},"reference-count":6,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Antecedentes: La urticaria se define como la presencia de habones, angioedema o ambas. Del 10-28% de los pacientes presentan enfermedades autoinmunes. El 20% cuentan anticuerpos anti- tiroideos y solo 5- 10% presentan cl\u00ednica. Actualmente se reconocen 2 endotipos principales tipo I (antial\u00e9rgica) por autoanticuerpos IgE anti TPO, la tipo IIb (autoinmune) anticuerpos IgG e IgE anti FcER1. Sin embargo, el 51% de los pacientes presentan una sobreposici\u00f3n I\/IIb.\nReporte de caso: Cuadro cl\u00ednico: Femenina de 46 a\u00f1os, con antecedente de hipertiroidismo sin tratamiento, presencia de habones pruriginosos generalizados con angioedema facial, con m\u00e1s de 50 habones por d\u00eda, duraci\u00f3n &lt; 24h, desaparecen sin dejar m\u00e1cula residual, con prurito 10\/10, si interfiere con el sue\u00f1o y con calidad de vida, sin factor desencadenante. Laboratorio: Eo 5.3% (260), IgE T 471 TSH 0.005 T4L 1.65 C3 138 C4 30 Anti TPO 219 anti-TG 332. Prueba de suero aut\u00f3logo positiva. Evoluci\u00f3n: Se inicia tratamiento con Levocetirizina 10 mg cada 12h, a los 2 meses presenta disminuci\u00f3n de s\u00edntomas.\nConclusi\u00f3n: No existen estad\u00edsticas espec\u00edficas sobre la prevalencia combinada de hipertiroidismo y la urticaria cr\u00f3nica a nivel mundial. En este caso la paciente presenta IgE elevada, enfermedad autoinmune y suero aut\u00f3logo positiva, esto hace el diagn\u00f3stico de sobreposici\u00f3n tipo I\/IIb. Actualmente no existe una forma de clasificaci\u00f3n de los tipos de urticaria que se aplique a cualquier contexto cl\u00ednico, generando un impacto en las decisiones terap\u00e9uticas y pron\u00f3sticas del paciente.\nPalabras clave: Hipertiroidismo; Urticaria cr\u00f3nica espont\u00e1nea autoinmune; Enfermedad de graves; Sobreposici\u00f3n tipo I\/IIb; Autoanticuerpos.<\/jats:p>","DOI":"10.29262\/ram.v72i3.1501","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:22:30Z","timestamp":1759242150000},"page":"229","source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;Urticaria Cr\u00f3nica Espont\u00e1nea con Superposici\u00f3n de endotipos tipo I\/IIb en un paciente con enfermedad de Graves &lt;\/b&gt;","&lt;b&gt;Chronic spontaneous urticaria with overlapping type I\/IIb endotypes in a patient with Graves\u2019 disease\u00a0&lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"given":"Karla Daniela","family":"Martinez Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Altagracia","family":"Contreras Tejada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Albarran Godinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Velazquez Samano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoselin Itzel","family":"Sanchez Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Circe Karime","family":"Ruiz Palafox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"62694","unstructured":"aFranchi , S. (18 de Marzo de 2025). Clinical manifestations and diagnosis of Graves disease . Obtenido de UpToDate : https:\/\/www.uptodate.com\/contents\/clinical-manifestations-and-diagnosis-of-graves-diseases"},{"key":"62695","doi-asserted-by":"crossref","unstructured":"Kolkhir, P. (2024). Chronic Spontaneous Urticaria A Review . JAMA , 1464-1466.","DOI":"10.1001\/jama.2024.15568"},{"key":"62696","doi-asserted-by":"crossref","unstructured":"Rothfeld, B. (1968). Pruritus as a symptom in hyperthyroidism . JAMA .","DOI":"10.1001\/jama.1968.03140270076022"},{"key":"62697","doi-asserted-by":"crossref","unstructured":"Subothini , S. (2018 ). Chronic urticaria and thyroid autoimmunity: a perplexing association . Oxford Medical Case Reports .","DOI":"10.1093\/omcr\/omx099"},{"key":"62698","doi-asserted-by":"crossref","unstructured":"Tienforti , D. (2022). Chronic Urticaria and thyroid autoimmunity: a meta-analysis of case-control studies . Journal of Endocrinological Investigation , 1317-1326.","DOI":"10.1007\/s40618-022-01761-2"},{"key":"62699","doi-asserted-by":"crossref","unstructured":"Womack , N. (2021). Urticaria as a manifestation of hyperthyroidism . Wiley .","DOI":"10.22541\/au.159112170.04349002"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1513\/2765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1513\/2765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:22:32Z","timestamp":1759242152000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i3.1501","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}