{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:56:39Z","timestamp":1760648199255,"version":"build-2065373602"},"reference-count":6,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>\u00a0\nIntroducci\u00f3n: El s\u00edndrome de Ormond, o fibrosis retroperitoneal idiop\u00e1tica, es una enfermedad rara con una incidencia anual de 0.1 a 0.4 casos por cada 100,000 habitantes y una prevalencia de 1.4 por cada 100,000 habitantes. Afecta principalmente a hombres (2- 3:1), con diagn\u00f3stico entre los 40 y 60 a\u00f1os. Se caracteriza por el crecimiento de tejido fibroinflamatorio en el retroperitoneo, con posible compresi\u00f3n de estructuras vasculares y urinarias. Su diagn\u00f3stico es complejo y requiere descartar malignidad u otras causas secundarias. Presentamos un caso con diagn\u00f3stico tard\u00edo y referencia a inmunolog\u00eda por hipogammaglobulinemia secundaria a rituximab.\nReporte de caso: Paciente masculino de 54 a\u00f1os con enfermedad renal cr\u00f3nica en hemodi\u00e1lisis, diagnosticado en 2006 con fibrosis retroperitoneal tras hallazgos de estenosis ureteral y masas peria\u00f3rticas. Se realizaron biopsias, descartando malignidad e IgG4-RD. En 2023, recibi\u00f3 rituximab por reactivaci\u00f3n inflamatoria, con mejor\u00eda cl\u00ednica, pero desarroll\u00f3 hipogammaglobulinemia severa (IgG &lt;500 mg\/dL), motivando su env\u00edo a inmunolog\u00eda. Se inici\u00f3 inmunoglobulina subcut\u00e1nea con estabilizaci\u00f3n cl\u00ednica. Un hallazgo previo relevante fue la IgG3 baja antes del rituximab, sin relaci\u00f3n clara con el s\u00edndrome de Ormond.\nConclusi\u00f3n: Este caso destaca la importancia de considerar el s\u00edndrome de Ormond en fibrosis retroperitoneal no explicada y la necesidad de un abordaje multidisciplinario. Asimismo, subraya la importancia del diagn\u00f3stico temprano y del seguimiento estrecho en pacientes con enfermedad fibroinflamatoria cr\u00f3nica, as\u00ed como la vigilancia inmunol\u00f3gica en aquellos que reciben inmunosupresi\u00f3n, para prevenir y tratar complicaciones asociadas. Dado su baja frecuencia, es fundamental documentar m\u00e1s casos para mejorar el conocimiento y manejo de esta patolog\u00eda.\nPalabras Clave: S\u00edndrome de ormond; Fibrosis retroperitoneal; Hipogammaglobulinemia; Rituximab; Inmunodeficiencia secundaria.<\/jats:p>","DOI":"10.29262\/ram.v72i3.1515","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:24:34Z","timestamp":1759242274000},"page":"233","source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;S\u00edndrome de Ormond: diagn\u00f3stico raro en paciente con hipogammaglobulinemia secundaria a rituximab &lt;\/b&gt;","&lt;b&gt;\u00a0 Ormond syndrome: a rare diagnosis in a patient with hypogammaglobulinemia secondary to rituximab\u00a0&lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"given":"Jaime Armando","family":"Soto Dom\u00ednguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Daniela","family":"Castillo Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Rodr\u00edguez Carbajal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marya Lizzeth","family":"Solis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noem\u00ed","family":"G\u00f3mez Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"62707","doi-asserted-by":"crossref","unstructured":"Steimer A, Becker MO. Treatment approaches for idiopathic retroperitoneal fibrosis: a systematic review with meta-analysis. BMC Rheumatol. 2025;9(12).","DOI":"10.1186\/s41927-024-00445-z"},{"key":"62708","doi-asserted-by":"crossref","unstructured":"doi: 10.1186\/s41927-024-00445-z.","DOI":"10.1186\/s41927-024-00445-z"},{"key":"62709","unstructured":"Altshuler E. Atypical presentation of idiopathic retroperitoneal fibrosis effectively treated with colchicine after lymphoma misdiagnosis. Cureus."},{"key":"62710","unstructured":"2023;15(10):e14756. doi:10.7759\/cureus. 14756"},{"key":"62711","doi-asserted-by":"crossref","unstructured":"Maachi Y, Foumzitizi J, Zerda H, Slaoui A, Karmouni T, El Khader K, et al. Retroperitoneal fibrosis: review of the literature. J Urol Res. 2024;11(2):1149.","DOI":"10.15406\/ijrrt.2024.11.00383"},{"key":"62712","unstructured":"Published 17 May 2024."}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1515\/2769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1515\/2769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:24:37Z","timestamp":1759242277000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i3.1515","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}