{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:58:10Z","timestamp":1759334290946,"version":"build-2065373602"},"reference-count":3,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Introducci\u00f3n: La evaluaci\u00f3n del paciente con asma utiliza herramientas cl\u00ednicas como el Asthma Control Test (ACT), pruebas de funci\u00f3n pulmonar y biomarcadores. Entre estos, un valor elevado de la fracci\u00f3n exhalada de \u00f3xido n\u00edtrico (FeNO) puede predecir un mayor riesgo de exacerbaciones, respuesta a corticosteroides y\/o terapias biol\u00f3gicas, aunque no siempre refleja un mal control cl\u00ednico. Nuestro objetivo fue determinar la relaci\u00f3n entre la gravedad del asma y los niveles de FeNO en pacientes que acuden a nuestro servicio.\nM\u00e9todos: estudio transversal en pacientes mayores de 12 a\u00f1os con asma controlada evaluados por ACT, se determin\u00f3 el FeNO mediante dispositivo NIOX-VERO\u00ae. Se aplic\u00f3 an\u00e1lisis descriptivo y coeficiente de correlaci\u00f3n de Spearman.\nResultados: se incluyeron 36 pacientes (66.7% mujeres) con una edad promedio de 36.3 a\u00f1os (DE \u00b1 14.4). Seg\u00fan GINA, 63.9% presentaron asma leve y 36.1% asma moderada. El 22.2% obtuvo un nivel de FeNO bajo (&lt;25ppb) y 52.8% un nivel alto (&gt;50ppb). La media de FeNO en asma leve fue 62.7 ppb (DE \u00b1 62.7) y con asma moderada 54.8 ppb (DE \u00b1 36.2). No se encontr\u00f3 una correlaci\u00f3n significativa entre gravedad del asma y niveles de FeNO (rs = 0.150, p = 0.306).\nConclusiones: aunque m\u00e1s de la mitad de los pacientes present\u00f3 niveles elevados de FeNO, no se observ\u00f3 una asociaci\u00f3n significativa con la gravedad del asma. Este hallazgo coincide con estudios previos y sugiere que el FeNO,si bien \u00fatil como biomarcador de inflamaci\u00f3n tipo 2, no debe utilizarse de manera aislada para evaluar la severidad cl\u00ednica.\nPalabras clave: ACT; FeNO; GINA; Gravedad del asma.<\/jats:p>","DOI":"10.29262\/ram.v72i3.1517","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:21:29Z","timestamp":1759242089000},"page":"227","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Relaci\u00f3n de los niveles de FeNO con la gravedad del asma: estudio transversal en el Hospital Universitario de Puebla &lt;\/b&gt;","&lt;b&gt;Relationship between FeNO levels and asthma severity: a cross-sectional study at the University Hospital of Puebla\u00a0&lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"given":"Jorge Andres","family":"Naranjo Vallejo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jes\u00fas","family":"R\u00edos L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida In\u00e9s","family":"L\u00f3pez Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Rivero Yeverino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrystopherson Gengyny","family":"Caballero L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Sergio","family":"Papaqui Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"62726","doi-asserted-by":"crossref","unstructured":"1. Larenas-Linnemann D, Gochicoa-Rangel L, Mac\u00edas-Weinmann A, Soto-Ramos M, Luna-Pech JA, Elizondo-R\u00edos A, et al. Consenso mexicano en relaci\u00f3n con la fracci\u00f3n exhalada de \u00f3xido n\u00edtrico en asma. Rev Alerg Mex. 2020;67 Supl 2:S1-S25.","DOI":"10.29262\/ram.v67i0.760"},{"key":"62727","unstructured":"2. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2025. Updated May 2025. Available from: https:\/\/ginasthma.org\/2025-report\/."},{"key":"62728","doi-asserted-by":"crossref","unstructured":"3. Murugesan, N.; Saxena, D.; Dileep, A.; Adrish, M.; Hanania, N.A. Update on the Role of FeNO in Asthma Management. Diagnostics 2023, 13, 1428. https:\/\/doi.org\/ 10.3390\/diagnostics13081428","DOI":"10.3390\/diagnostics13081428"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1517\/2763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1517\/2763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:21:32Z","timestamp":1759242092000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":3,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i3.1517","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}