{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:57:06Z","timestamp":1759334226273,"version":"build-2065373602"},"reference-count":3,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>\u00a0\nIntroducci\u00f3n: En pacientes al\u00e9rgicos con infecciones respiratorias recurrentes se ha descrito la asociaci\u00f3n de deficiencia de anticuerpos, tanto selectivas como de respuesta a polisac\u00e1ridos.\nReporte de caso: Hombre, sin antecedentes familiares de importancia, a los 5 a\u00f1os adenopat\u00edas cervicales y axilares con biopsia que descart\u00f3 malignidad, con posterior remisi\u00f3n. A los 7 a\u00f1os s\u00edntomas nasales y sibilancias, ingresa a Alergia a los 9 a\u00f1os y se diganostic\u00f3 asma y rinitis, sensibilizado a \u00e1caro y pasto. Buena respuesta a inmunoterapia primeros 2 a\u00f1os, el tercer a\u00f1o inicia con infecciones respiratorias y digestivas recurrentes hasta cada 15 d\u00edas. A los 13 a\u00f1os se decide extensi\u00f3n de estudios. Exploraci\u00f3n f\u00edsica: peso 69kg, talla 1.7m, cornnetes obstructivos, \u00favula central, b\u00edfida, am\u00edgdalas GI, sin adenopat\u00edas, cardiopulmonar sin alteraciones. Estudios: Hemoglobina 15.6, Hematocrito 46%, Leucocitos 4005, Linfocitos 1200 (20%), Eosin\u00f3filos 210 (3.6%), plaquetas 219000, IgA 23 baja(45-236), IgM 27 baja(52-242), IgE 11.9(3.100UI), IgG 1060 normal(560-1760) corroboradas. Citometr\u00eda de flujo normal y linfocitos B normales. Se realiza prueba de polisac\u00e1ridos antineumoc\u00f3cica solo con buena respuesta a 4 serotipos, &lt;50% de respuesta. Se dio manejo temporal con antibi\u00f3tico profil\u00e1ctico m\u00e1s inmunoestimulantes con mejor\u00eda de procesos infecciosos. Actualmente sin profilaxis. Discusi\u00f3n: Adolescente con defecto cuantitativo de IgA e IgM y al momento con niveles normales de IgG con respuesta alterada a vacuna de polisac\u00e1ridos, se mantiene en vigilancia inmunol\u00f3gica ante la posibilidad de presentar inmunodeficiencia comun variable.\nConclusi\u00f3n: Las infecciones recurrentes o invasivas en pacientes ya tratados con asma amerita abordaje para defecto de anticuerpos.\nPalabras claves: Inmunodeficiencia primaria; Deficiencia de anticuerpos; Hipogammaglobulinemia; Asma; L\u00ednea media.<\/jats:p>","DOI":"10.29262\/ram.v72i3.1542","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:30:04Z","timestamp":1759242604000},"page":"242","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Inmunodeficiencia primaria con hipogammaglobulinemia y defecto m\u00ednino de la l\u00ednea media&lt;\/b&gt;","&lt;b&gt;\u00a0 Primary immunodeficiency with hypogammaglobulinemia and minimum midline defect\u00a0&lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"given":"Alfredo Atl","family":"Castillo Sigales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"63531","doi-asserted-by":"crossref","unstructured":"Casta\u00f1o-Jaramillo LM, Munevar A, Mar\u00edn AC, Villamil M, Restrepo S, V\u00e9lez N. Clinical and immunological features of specific antibody deficiency in a pediatric hospital in Colombia. Biomedica. 2024 Dec 23;44(Sp. 2):72-79. doi: 10.7705\/biomedica.7562.","DOI":"10.7705\/biomedica.7562"},{"key":"63532","doi-asserted-by":"crossref","unstructured":"Kirkpatrick CH. Specific polysaccharide antibody deficiency. Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology. 2006 Sep;97(3):271. DOI: 10.1016\/s1081-1206(10)60788-0.","DOI":"10.1016\/S1081-1206(10)60788-0"},{"key":"63533","doi-asserted-by":"crossref","unstructured":"Daniel M Musher, Specific Polysaccharide Antibody Deficiency, Clinical Infectious Diseases, Volume 77, Issue 6, 15 September 2023, Pages 932\u2013933. doi.org\/10.1093\/cid\/ciad354","DOI":"10.1093\/cid\/ciad354"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1542\/2777","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1542\/2777","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:30:06Z","timestamp":1759242606000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":3,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i3.1542","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}