{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:56:39Z","timestamp":1760648199381,"version":"build-2065373602"},"reference-count":12,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"3","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Introducci\u00f3n: El s\u00edndrome de DRESS conocido por sus siglas en ingl\u00e9s (Drug Reaction with Eosinophilia and Systemic Symptoms) es una reacci\u00f3n de hipersensibilidad relacionada a medicamentos que se manifiesta con eosinofilia, s\u00edntomas sist\u00e9micos y en ocasiones potencialmente mortal. Se caracteriza cl\u00ednicamente por presentar un exantema generalizado, fiebre, edema facial y falla multiorg\u00e1nica. Se puede acompa\u00f1ar de hallazgos paracl\u00ednicos los cuales son leucocitosis, eosinofilia y alteraciones en pruebas de funci\u00f3n renal y hep\u00e1tica.\nReporte De Caso: Se presenta el caso de una paciente femenina de 10 a\u00f1os, la cual es hospitalizada por el diagnostico de una pansinusitis complicada con un empiema epidural el cual requiri\u00f3 drenaje quir\u00fargico, previo a esto se encontraba en manejo con levetiracetam. Tras el evento quir\u00fargico se mantiene con triple esquema a base de vancomicina, ceftriaxona y metronidazol. Al finalizar dicho tratamiento, desarrollo una dermatosis generalizada que no respondi\u00f3 a antihistam\u00ednicos de segunda generaci\u00f3n ni corticoesteroides. Posterior a esto inicia con fiebre, edema facial y una crisis convulsiva, se solicitan estudios de laboratorio evidenciando leucocitosis y eosinofilia. Se sospecho de s\u00edndrome de DRESS, con una puntuaci\u00f3n de RegiSCAR de 5, que corresponde a un caso probable. Se inicio tratamiento con inmunoglobulina observando mejor\u00eda cl\u00ednica y resoluci\u00f3n del cuadro.\nConclusiones: El s\u00edndrome de DRESS es una reacci\u00f3n inducida por f\u00e1rmacos grave, su tasa de mortalidad estimada es del 10%. El reconocimiento temprano e inicio oportuno del tratamiento son fundamentales para el pron\u00f3stico y la prevenci\u00f3n de posibles complicaciones.\nPalabras Clave: DRESS; Eosinofilia; Reacci\u00f3n adversa relacionada con medicamentos.<\/jats:p>","DOI":"10.29262\/ram.v72i3.1549","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:31:27Z","timestamp":1759242687000},"page":"245","source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;S\u00edndrome de DRESS asociado al uso de levetiracetam en paciente pedi\u00e1trico. Reporte de un caso &lt;\/b&gt;","&lt;b&gt;DRESS syndrome associated with levetiracetam use in a pediatric patient. A case report\u00a0&lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"given":"Tania Guadalupe","family":"Gomez Moreno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"63687","doi-asserted-by":"crossref","unstructured":"1. Calle AM, Aguirre N, Ardila JC, Cardona Villa R. DRESS syndrome: A literature review and treatment algorithm. World Allergy Organization Journal. 2023;16(3). doi:10.1016\/j.waojou.2022.100673","DOI":"10.1016\/j.waojou.2022.100673"},{"key":"63688","unstructured":"2. Pedro M, Andr\u00e9s C, Mauricio C, et al. S\u00edndrome de DRESS CASO CL\u00cdNICO S\u00edndrome de DRESS. Vol 23.; 2021. http:\/\/orcid.org\/0000-0001-"},{"key":"63689","doi-asserted-by":"crossref","unstructured":"3. Wolfson AR, Zhou L, Li Y, Phadke NA, Chow OA, Blumenthal KG. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Identified in the Electronic Health Record Allergy Module. Journal of Allergy and Clinical Immunology: In Practice. 2019;7(2):633-640. doi:10.1016\/j.jaip.2018.08.013","DOI":"10.1016\/j.jaip.2018.08.013"},{"key":"63690","unstructured":"4. Clausell AB, Pacheco Otero Y, Manuel R, Ruiz P. S\u00edndrome de DRESS Asociado al Uso de Anticonvulsivantes DRESS Syndrome Associated to the Use of Anti-Convulsiveness. Vol 49.; 2020. http:\/\/scielo.sld.cuhttp:\/\/www.revmedmilitar.sld.cuBajolicenciaCreativeCommonsPresentaci\u00f3ndecasohttps:\/\/orcid.org\/0000-0001-8328-742X"},{"key":"63691","doi-asserted-by":"crossref","unstructured":"5. Berdugo J. S\u00cdNDROME DE DRESS INDUCIDO POR CARBAMAZEPINA. REVISTA ARGENTINA DE MEDICINA. 2024;12(3). doi:10.61222\/ram.v12i3.996","DOI":"10.61222\/ram.v12i3.996"},{"key":"63692","doi-asserted-by":"crossref","unstructured":"6. Husain Z, Reddy BY, Schwartz RA. DRESS syndrome. J Am Acad Dermatol. 2013;68(5):693.e1-693.e14. doi:10.1016\/j.jaad.2013.01.033","DOI":"10.1016\/j.jaad.2013.01.033"},{"key":"63693","unstructured":"7. Haur Yueh L, Y LH, K TL. Cutaneous Adverse Drug Reactions in Hospitalised Patients. Vol 51.; 2010."},{"key":"63694","doi-asserted-by":"crossref","unstructured":"8. Lam BD, Miller MM, Sutton A V., Peng D, Crew AB. Vancomycin and DRESS: A retrospective chart review of 32 cases in Los Angeles, California. J Am Acad Dermatol. 2017;77(5):973-975. doi:10.1016\/j.jaad.2017.05.041","DOI":"10.1016\/j.jaad.2017.05.041"},{"key":"63695","doi-asserted-by":"crossref","unstructured":"9. Ye Y \u2010M., Hur G \u2010Y., Kim S \u2010H., et al. Drug\u2010specific CD4 + T\u2010cell immune responses are responsible for antituberculosis drug\u2010induced maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms syndrome. British Journal of Dermatology. 2017;176(2):378-386. doi:10.1111\/bjd.14839","DOI":"10.1111\/bjd.14839"},{"key":"63696","doi-asserted-by":"crossref","unstructured":"10. Soria A, Bernier C, Veyrac G, Barbaud A, Puymirat E, Milpied B. Drug reaction with eosinophilia and systemic symptoms may occur within 2 weeks of drug exposure: A retrospective study. J Am Acad Dermatol. 2020;82(3):606-611. doi:10.1016\/j.jaad.2019.09.036","DOI":"10.1016\/j.jaad.2019.09.036"},{"key":"63697","doi-asserted-by":"crossref","unstructured":"11. Chiou C, Yang L, Hung S, et al. Clinicopathlogical features and prognosis of drug rash with eosinophilia and systemic symptoms: a study of 30 cases in Taiwan. Journal of the European Academy of Dermatology and Venereology. 2008;22(9):1044-1049. doi:10.1111\/j.1468-3083.2008.02585.x","DOI":"10.1111\/j.1468-3083.2008.02585.x"},{"key":"63698","doi-asserted-by":"crossref","unstructured":"12. de las Vecillas S\u00e1nchez L, Alenazy LA, Garcia-Neuer M, Castells MC. Drug hypersensitivity and desensitizations: Mechanisms and new approaches. Int J Mol Sci. 2017;18(6). doi:10.3390\/ijms18061316","DOI":"10.3390\/ijms18061316"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1549\/2780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1549\/2780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T14:31:37Z","timestamp":1759242697000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,30]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i3.1549","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"type":"electronic","value":"2448-9190"},{"type":"print","value":"0002-5151"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}