{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:44:55Z","timestamp":1776721495956,"version":"3.51.2"},"reference-count":20,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Antecedentes: La cromoblastomicosis (CBM) es una micosis subcut\u00e1nea cr\u00f3nica presente en regiones tropicales o subtropicales, causada por la inoculaci\u00f3n traum\u00e1tica de varias especies de hongos melanizados, los m\u00e1s comunes son Fonsecaea pedrosoi y Cladophialophora carrionii, se caracteriza en etapas tempranas por m\u00e1culas o p\u00e1pulas eritematosas con aspecto verrugoso o hiperquerat\u00f3sico, que progresan a morfolog\u00edas nodulares, verrugosas, tumorales, en placa o cicatriciales.\nObjetivo: describir una presentaci\u00f3n cl\u00e1sica y realizar una revisi\u00f3n narrativa de la CMB con un tiempo de evoluci\u00f3n prolongado y extensi\u00f3n multifocal.\nReporte de caso: Hombre de 69 a\u00f1os, de ocupaci\u00f3n agricultor con antecedentes de hipertensi\u00f3n arterial, falla cardiaca con FEVI conservada, diverticulosis col\u00f3nica y hernia umbilical. Ingres\u00f3 al servicio de urgencias por cuadro de un d\u00eda de disnea, escalofr\u00edos, astenia, adinamia y fiebre, compatible con neumopat\u00eda cr\u00f3nica exacerbada y neumon\u00eda; dado historial de 10 a\u00f1os de crecimiento progresivo de lesiones en piel tipo p\u00e1pulas indoloras y pruriginosas que se extendieron con distintas presentaciones a otras \u00e1reas del cuerpo, se le practic\u00f3 un estudio de hidr\u00f3xido de potasio (KOH) evidenciando estructuras mic\u00f3ticas y presencia de levaduras, mientras que la biopsia de piel report\u00f3 hallazgos de hiperplasia pseudoepiteliomatosa, y abscesos intraepid\u00e9rmicos con cuerpos de Medlar, patognom\u00f3nicos de la CBM.\nConclusi\u00f3n: Se resalta la relevancia de un diagn\u00f3stico acertado de una enfermedad tropical desatendida y la instauraci\u00f3n de tratamiento antimic\u00f3tico personalizado, adem\u00e1s de la necesidad de un monitoreo a largo plazo debido al car\u00e1cter cr\u00f3nico de la patolog\u00eda por su marcada resistencia al tratamiento.\nPalabras clave: Cromoblastomicosis; Enfermedades desatendidas; Dermatomicosis.<\/jats:p>","DOI":"10.29262\/ram.v72i4.1467","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:35:09Z","timestamp":1767828909000},"page":"367-371","source":"Crossref","is-referenced-by-count":0,"title":["&lt;b&gt;Cromoblastomicosis, una enfermedad tropical desatendida: reporte de caso y revisi\u00f3n narrativa &lt;\/b&gt;","&lt;b&gt;Overview of Chromoblastomycosis, a neglected tropical disease: case report and narrative review &lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1162-0362","authenticated-orcid":false,"given":"Angie Juliana","family":"Paternina Colorado","sequence":"first","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4889-0596","authenticated-orcid":false,"given":"Yadira","family":"Melo Mahecha","sequence":"additional","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3580-8221","authenticated-orcid":false,"given":"Julio C\u00e9sar","family":"Velasco Castro","sequence":"additional","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6967-1932","authenticated-orcid":false,"given":"Angie Lizeth","family":"Garz\u00f3n Pe\u00f1uela","sequence":"additional","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6023-2071","authenticated-orcid":false,"given":"Hector Juli\u00e1n","family":"Cubillos Vega","sequence":"additional","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2892-6795","authenticated-orcid":false,"given":"Sara Daniela","family":"Bernal Otalora","sequence":"additional","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-0900","authenticated-orcid":false,"given":"Lorena","family":"Garc\u00eda Agudelo","sequence":"additional","affiliation":[{"name":"Hospital Regional de la Orinoqu\u00eda, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"11808","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"65477","doi-asserted-by":"crossref","unstructured":"1. Shenoy MM, Girisha BS, Krishna S. Chromoblastomycosis: A Case Series and Literature Review. Indian Dermatol Online J 2023; 14 (5): 665-669. doi: 10.4103\/idoj.idoj_292_23.","DOI":"10.4103\/idoj.idoj_292_23"},{"key":"65478","doi-asserted-by":"crossref","unstructured":"2. Santos DWCL, de Azevedo C de MP e S, Vicente VA, et al. The global burden of chromoblastomycosis. PLoS Negl Trop Dis 2021; 15 (8): e0009611. doi: 10.1371\/journal.pntd.0009611","DOI":"10.1371\/journal.pntd.0009611"},{"key":"65479","unstructured":"3. Chromoblastomycosis. World Health Organization 2023. https:\/\/www.who.int\/es\/news-room\/fact-sheets\/detail\/chromoblastomycosis"},{"key":"65480","doi-asserted-by":"crossref","unstructured":"4. Queiroz-Telles F, de Hoog S, Santos DWCL, et al. Chromoblastomycosis. Clin Microbiol Rev 2017; 30 (1): 233-276. doi: 10.1128\/CMR.00032-16","DOI":"10.1128\/CMR.00032-16"},{"key":"65481","doi-asserted-by":"crossref","unstructured":"5. Su\u00e1rez-Ospino N, Salas-Hine I, Qui\u00f1onez-Rodr\u00edguez A, Ochoa-D\u00edaz A, et al. Cromoblastomicosis verrugosa-cicatricial multifocal: una entidad desatendida en Colombia. Rev Chile Infectol 2023; 40 (3): 298-302. doi: 10.4067\/s0716-10182023000300298","DOI":"10.4067\/s0716-10182023000300298"},{"key":"65482","unstructured":"6. Garc\u00eda-G\u00f3mez D, L\u00f3pez-P\u00e9rez M, Adjudah-Truff\u00edn C. Diagn\u00f3stico microbiol\u00f3gico en un paciente con cromomicosis. Medicentro Electr\u00f3nica 2020; 691-698. http:\/\/scielo.sld.cu\/scielo.php?script=sci_arttext&pid=S1029-30432020000300691&lng=es."},{"key":"65483","doi-asserted-by":"crossref","unstructured":"7. Barbosa LSP, Souza YRC, Sasaki CS, Santos DWD, Rossato L. Chromoblastomycosis in Brazil: A review of 450 published cases. Rev Soc Bras Med Trop 2024; 57: e00205-2024. doi: 10.1590\/0037-8682-0132-2024.","DOI":"10.1590\/0037-8682-0132-2024"},{"key":"65484","doi-asserted-by":"crossref","unstructured":"8. Jahr C, Peruilh L, Jim\u00e9nez M, Bobadilla F, et al. Cromoblastomicosis. Primer caso al\u00f3ctono tratado en Chile. Rev Chile Infectol 2022; 39 (3): 349-353. doi: 10.4067\/s0716-10182022000200349","DOI":"10.4067\/s0716-10182022000200349"},{"key":"65485","doi-asserted-by":"crossref","unstructured":"9. Lau WC, Damji Y, Orlowski GM. An unusually subtle presentation of chromoblastomycosis. JAAD Case Rep 2023; 40: 11-13. doi: 10.1016\/j.jdcr.2023.07.029","DOI":"10.1016\/j.jdcr.2023.07.029"},{"key":"65486","doi-asserted-by":"crossref","unstructured":"10. Campos-Macias P, Arenas R, Aquino CJ, et al. Chromoblastomycosis caused by Fonsecaea monophora in Mexico. J Med Mycol 2021; 31 (2): 101114. doi: 10.1016\/j.mycmed.2021.101114","DOI":"10.1016\/j.mycmed.2021.101114"},{"key":"65487","doi-asserted-by":"crossref","unstructured":"11. Smith DJ, Queiroz-Telles F, Rabenja FR, et al. A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group. PLoS Negl Trop Dis 2024; 18 (10): e0012562. doi: 10.1371\/journal.pntd.0012562","DOI":"10.1371\/journal.pntd.0012562"},{"key":"65488","doi-asserted-by":"crossref","unstructured":"12. Informe Mundial Sobre Las Enfermedades Tropicales Desatendidas 2024. World Health Organization 2024. doi: 10.2471\/B09064","DOI":"10.2471\/B09064"},{"key":"65489","unstructured":"13. Kurien G, Sugumar K, Sathe NC, Chandran V. Chromoblastomycosis. In: StatPearls. Treasure Island (FL): StatPearls Publishing 2024; https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470253\/"},{"key":"65490","doi-asserted-by":"crossref","unstructured":"14. Oprea Y, Stringer T, Mattis D, Amin B, et al. Chromoblastomycosis Caused by Fonsecaea monophora Mimicking Lichen Planus. Cureus 2024; 16 (2): e53863. doi:10.7759\/cureus.53863","DOI":"10.7759\/cureus.53863"},{"key":"65491","doi-asserted-by":"crossref","unstructured":"15. Cinotti E, Cioppa V, Tognetti L, et al. Super-High Magnification Dermoscopy in 190 Clinically Atypical Pigmented Lesions. Diagnostics (Basel) 2023; 13 (13): 2238. doi: 10.3390\/diagnostics13132238","DOI":"10.3390\/diagnostics13132238"},{"key":"65492","doi-asserted-by":"crossref","unstructured":"16. Cortonesi G, Cosetti D, Suppa M, Habougit C, et al. Non-invasive Imaging Techniques for the Diagnosis of Chromoblastomycosis. Dermatol Pract Concept 2024; 14 (4): e2024236. doi: 10.5826\/dpc.1404a236","DOI":"10.5826\/dpc.1404a236"},{"key":"65493","doi-asserted-by":"crossref","unstructured":"17. Falgout L, Hilton D. Clinical presentation and management of chromoblastomycosis: A case report and review. Med Mycol Case Rep 2023; 41: 8-10. doi: 10.1016\/j.mmcr.2023.05.004","DOI":"10.1016\/j.mmcr.2023.05.004"},{"key":"65494","doi-asserted-by":"crossref","unstructured":"18. Khodeir J, Ohanian P, Megarbane HAR. Triple therapy approach for treating chromoblastomycosis in a Lebanese patient. Clin Case Rep 2024; 12 (10). doi: 10.1002\/ccr3.9392","DOI":"10.1002\/ccr3.9392"},{"key":"65495","doi-asserted-by":"crossref","unstructured":"19.Zheng J, Liu S, Xie Z, et al. Successful management of chromoblastomycosis utilizing conventional antifungal agents and imiquimod therapy. Ann Clin Microbiol Antimicrob 2024; 23 (1): 57. doi: 10.1186\/s12941-024-00718-y","DOI":"10.1186\/s12941-024-00718-y"},{"key":"65496","doi-asserted-by":"crossref","unstructured":"20. Martinelli MB, Cockerell CJ, Cohen PR. Treatment-Resistant Chromoblastomycosis Successfully Managed With Surgical Excision. Cureus 2024; 16 (11): e73619. doi: 10.7759\/cureus.73619","DOI":"10.7759\/cureus.73619"}],"container-title":["Revista Alergia M\u00e9xico"],"original-title":[],"link":[{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1467\/2797","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1467\/2820","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/download\/1467\/2797","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T20:56:53Z","timestamp":1776718613000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistaalergia.mx\/ojs\/index.php\/ram\/article\/view\/1467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,19]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12,19]]}},"URL":"https:\/\/doi.org\/10.29262\/ram.v72i4.1467","relation":{},"ISSN":["2448-9190","0002-5151"],"issn-type":[{"value":"2448-9190","type":"electronic"},{"value":"0002-5151","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12,19]]}}}