{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:58:43Z","timestamp":1783688323768,"version":"3.55.0"},"reference-count":64,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>La alergia a la prote\u00edna de la leche de vaca es el nombre que se le otorga a la reacci\u00f3n adversa derivada de los componentes proteicos de este l\u00edquido. La leche contiene prote\u00ednas con potencial alerg\u00e9nico, que se clasifican en case\u00ednas y las prote\u00ednas del suero. En particular la \u03b1-lactoalb\u00famina y la \u03b2-lactoglobulina, presentes en el suero, pueden ser responsables de una respuesta inmunol\u00f3gica espec\u00edfica mediada o no por inmunoglobulina E (IgE). La superaci\u00f3n de este tipo de alergia mediante la adecuada alimentaci\u00f3n de la madre puede traducirse en lograr tolerancia oral mediada por la lactancia materna. La lactancia materna no s\u00f3lo provee una adecuada alimentaci\u00f3n sino del desarrollo de microbiota intestinal. Ambos elementos: microflora y proceso de la tolerancia oral mediada por la leche materna, permiten aportar adem\u00e1s una carga m\u00ednima de al\u00e9rgenos, seg\u00fan lo demostrado a\u00fan en modelos de laboratorio (ratones). La presente revisi\u00f3n muestra los antecedentes t\u00e9cnicos de la alergia a la prote\u00edna de la leche de vaca.\nPalabras clave: Alergia a la prote\u00edna de la vaca (APLV); Inmunoglobulina E (IgE); Al\u00e9rgenos; Lactantes.<\/jats:p>","DOI":"10.29262\/ram.v72i4.1473","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:32:09Z","timestamp":1767828729000},"page":"318-330","source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;Alergia a la prote\u00edna de la leche de vaca &lt;\/b&gt;","&lt;b&gt;Cow\u2019s Milk Allergy &lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1866-916X","authenticated-orcid":false,"given":"Elena","family":"Ortiz-Fonseca","sequence":"first","affiliation":[{"name":"Salud y Vitalidad S.A, San Jos\u00e9, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9435-5117","authenticated-orcid":false,"given":"Alejandro","family":"Hern\u00e1ndez-Soto","sequence":"additional","affiliation":[{"name":"Instituto Tecnol\u00f3gico de Costa Rica (TEC), Escuela de Biolog\u00eda, Centro de Investigaci\u00f3n en Biotecnolog\u00eda (CIB), Cartago, Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"65321","doi-asserted-by":"crossref","unstructured":"1. 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