{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:16:47Z","timestamp":1782836207402,"version":"3.54.5"},"reference-count":17,"publisher":"Colegio Mexicano de Inmunologia Clinica y Alergia, A. C.","issue":"4","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Alerg Mex"],"abstract":"<jats:p>Objetivo: Describir las caracter\u00edsticas cl\u00ednicas de las enfermedades al\u00e9rgicas (EA) como comorbilidades \u2014distintas de las enfermedades at\u00f3picas primarias (EAP)\u2014 en pacientes pedi\u00e1tricos con diagn\u00f3stico de errores innatos de la inmunidad (IEI).\nM\u00e9todos: Estudio observacional y retrospectivo, efectuado en una poblaci\u00f3n pedi\u00e1trica con diagn\u00f3stico de IEI y comorbilidad al\u00e9rgica, atendidos entre 2013 y 2023. El diagn\u00f3stico se bas\u00f3 en los criterios de ESID y IUIS-2022. Se realiz\u00f3 un an\u00e1lisis descriptivo de variables (frecuencias\/porcentajes). Para las variables cualitativas se utiliz\u00f3 raz\u00f3n de momios (OR), con la intenci\u00f3n de estimar la probabilidad de sensibilizaci\u00f3n al\u00e9rgica. Los an\u00e1lisis se realizaron con R Studio versi\u00f3n 3.2.2.\nResultados: Se registraron 366 pacientes con IEI y de estos 238 manifestaron EA concomitante (59.6% hombres; edad media: 5 a\u00f1os). Los tipos de IEI m\u00e1s frecuentes fueron las deficiencias espec\u00edficas de anticuerpos (84%), seguidas por inmunodeficiencias combinadas asociadas a s\u00edndromes (8%), defectos cong\u00e9nitos de fagocitos (2.9%), inmunodeficiencias combinadas (2.5%), enfermedades autoinflamatorias (1.7%) y defectos de inmunidad innata (0.8%). Las EA incluyeron asma (48.7%), rinitis (18.9%), dermatitis at\u00f3pica (15.1%), alergia alimentaria (8.4%), urticaria aguda (5%) y urticaria cr\u00f3nica (3.8%).\nConclusi\u00f3n: Las EA son un signo de alerta cada vez m\u00e1s reconocido para la detecci\u00f3n temprana de IEI. Su coexistencia, sin ser necesariamente EAP, destaca la necesidad de un abordaje integral y multidisciplinario.\nPalabras clave: Errores innatos de la inmunidad; Enfermedades al\u00e9rgicas; Sensibilizaci\u00f3n; Reacciones de hipersensibilidad.<\/jats:p>","DOI":"10.29262\/ram.v72i4.1484","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T23:29:30Z","timestamp":1767828570000},"page":"290-295","source":"Crossref","is-referenced-by-count":1,"title":["&lt;b&gt;Allergic comorbidities among inborn errors of immunity in children attended in a high-complexity center in Cali, Colombia &lt;\/b&gt;","&lt;b&gt;Comorbilidades al\u00e9rgicas en pacientes pedi\u00e1tricos con errores innatos de la inmunidad atendidos en un centro de alta complejidad en Cali, Colombia &lt;\/b&gt;"],"prefix":"10.29262","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8295-3958","authenticated-orcid":false,"given":"Jacobo","family":"Trivi\u00f1o Arias","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-0710","authenticated-orcid":false,"given":"Sof\u00eda","family":"Martinez Betancur","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9792-2359","authenticated-orcid":false,"given":"Oriana","family":"Arias Valderrama","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4384-2024","authenticated-orcid":false,"given":"Tania Marcela","family":"Guzman","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5137-9384","authenticated-orcid":false,"given":"Juan Pablo","family":"Diaz Sol\u00f3rsano","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1465-7957","authenticated-orcid":false,"given":"Diego","family":"Medina","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3173-6059","authenticated-orcid":false,"given":"Alexis","family":"Franco","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-3606","authenticated-orcid":false,"given":"Jaime","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Marsela","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2672-0439","authenticated-orcid":false,"given":"Harry Mauricio","family":"Pachajoa","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-8928","authenticated-orcid":false,"given":"Manuela","family":"Olaya Hernandez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"11808","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"65248","doi-asserted-by":"crossref","unstructured":"1. Tangye SG, Al-Herz W, Aziz Bousfiha \u00b7, Cunningham-Rundles C, Jose \u00b7, Franco L, et al. Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee. https:\/\/doi.org\/10.1007\/s10875-022-01289-3","DOI":"10.1007\/s10875-022-01289-3"},{"key":"65249","doi-asserted-by":"crossref","unstructured":"2. Raje N, Dinakar C. Overview of Immunodeficiency Disorders. Immunol Allergy Clin North Am [Internet]. 2015; 35 (4): 599. \/pmc\/articles\/PMC4600970\/","DOI":"10.1016\/j.iac.2015.07.001"},{"key":"65250","doi-asserted-by":"crossref","unstructured":"3. Amaya-Uribe L, Rojas M, Azizi G, Anaya JM, Gershwin ME. Primary immunodeficiency and autoimmunity: A comprehensive review. J Autoimmun. 2019; 99: 52-72. https:\/\/pubmed.ncbi.nlm.nih.gov\/30795880\/","DOI":"10.1016\/j.jaut.2019.01.011"},{"key":"65251","doi-asserted-by":"crossref","unstructured":"4. Chapel H, Prevot J, Gaspar HB, Espa\u00f1ol T, Bonilla FA, Solis L, et al. Primary immune deficiencies - principles of care. Front Immunol. 2014; 5 (DEC). https:\/\/pubmed.ncbi.nlm.nih.gov\/25566243\/","DOI":"10.3389\/fimmu.2014.00627"},{"key":"65252","unstructured":"5. Inborn errors of immunity (primary immunodeficiencies): Classification. 2024. https:\/\/medilib.ir\/uptodate\/show\/117758"},{"key":"65253","unstructured":"6. Leonardi L, Rivalta B, Cancrini C, Chiappini E, et al. Update in Primary Immunodeficiencies. Acta Biomed. 2020; 91 (11-S): 1-6. https:\/\/pubmed.ncbi.nlm.nih.gov\/33004780\/"},{"key":"65254","doi-asserted-by":"crossref","unstructured":"7. Chan SK, Gelfand EW. Primary Immunodeficiency Masquerading as Allergic Disease. Immunol Allergy Clin North Am 2015; 35 (4): 767-78. https:\/\/pubmed.ncbi.nlm.nih.gov\/26454318\/","DOI":"10.1016\/j.iac.2015.07.008"},{"key":"65255","unstructured":"8. 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J Allergy Clin Immunol 2021; 148 (5): 1332-1341.e5. https:\/\/pubmed.ncbi.nlm.nih.gov\/33895260\/"},{"key":"65259","doi-asserted-by":"crossref","unstructured":"12. Smith KL, Dai D, Modi BP, Sara R, et al. Inborn Errors of Immunity Associated With Type 2 Inflammation in the USIDNET Registry. Front Immunol 2022; 13. https:\/\/pubmed.ncbi.nlm.nih.gov\/35273610\/","DOI":"10.3389\/fimmu.2022.831279"},{"key":"65260","doi-asserted-by":"crossref","unstructured":"13. Ogershok PR, Hogan MB, Welch JE, Corder WT, et al. Spectrum of illness in pediatric common variable immunodeficiency. Ann Allergy Asthma Immunol 2006; 97 (5): 653-6. https:\/\/pubmed.ncbi.nlm.nih.gov\/17165275\/","DOI":"10.1016\/S1081-1206(10)61096-4"},{"key":"65261","doi-asserted-by":"crossref","unstructured":"14. El-Sayed ZA, El-Ghoneimy DH, Ortega-Martell JA, Radwan N, et al. Allergic manifestations of inborn errors of immunity and their impact on the diagnosis: A worldwide study. World Allergy Org J 2022; 15 (6): 100657.","DOI":"10.1016\/j.waojou.2022.100657"},{"key":"65262","doi-asserted-by":"crossref","unstructured":"15. Edwards E, Razvi S, Cunningham-Rundles C. IgA deficiency: Clinical correlates and responses to pneumococcal vaccine. Clinical Immunology 2004; 111 (1): 93-7. https:\/\/pubmed.ncbi.nlm.nih.gov\/15093556\/","DOI":"10.1016\/j.clim.2003.12.005"},{"key":"65263","doi-asserted-by":"crossref","unstructured":"16. Chin A, Balasubramanyam S, Davis CM. Very Elevated IgE, Atopy, and Severe Infection: A Genomics-Based Diagnostic Approach to a Spectrum of Diseases. Case Reports Immunol 2021; 2021.","DOI":"10.1155\/2021\/2767012"},{"key":"65264","doi-asserted-by":"crossref","unstructured":"17. Vaseghi-Shanjani M, Smith KL, Sara RJ, Modi BP, et al. Inborn errors of immunity manifesting as atopic disorders. 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